Navigation Links
BRAVE-3 Questions Value of Abciximab in PCI for Heart Attack
Date:3/30/2008

With high-dose clopidogrel, the intravenous anti-platelet drug appears

unnecessary

CHICAGO, March 30 /PRNewswire/ -- Over the years, interventional cardiologists have made many improvements in percutaneous coronary intervention (PCI) for patients with heart attack, among the most important, refinements in the selection and administration of drugs that prevent unwanted blood clotting. Now a new study has found that high loading doses of clopidogrel, an oral medication that inhibits blood clots by preventing platelets from clumping together, can eliminate the need for intravenous abciximab, a standard cath-lab drug that also interferes with platelets, but through a different pathway.

The BRAVE-3 study is the first to test the influence of high-dose clopidogrel on the value of abciximab exclusively in patients with ST-elevation myocardial infarction (STEMI), a serious form of heart attack. The study is being reported today in a Late-Breaking Clinical Trials session at the SCAI Annual Scientific Sessions in Partnership with ACC i2 Summit (SCAI-ACCi2) in Chicago. SCAI-ACCi2 is a scientific meeting for practicing cardiovascular interventionalists sponsored by the Society for Cardiovascular Angiography and Interventions (SCAI) in partnership with the American College of Cardiology (ACC).

"Acute myocardial infarction is a major medical problem, and the present study will help to define the optimal treatment strategy," said Julinda Mehilli, MD, an associate professor and staff cardiologist at Deutsches Herzzentrum, Technical University, Munich, Germany. "Therapy without abciximab would certainly be more cost-effective and reduce the risk of bleeding complications."

For the study Dr. Mehilli and colleagues recruited 800 patients with STEMI who were undergoing PCI. All patients were pretreated with 600 mg of clopidogrel and then randomly assigned to receive intravenous abciximab or a placebo during the procedure.

The study was designed primarily to compare how the two treatment strategies affected the final amount of heart attack damage, as gauged by blood flow in the heart muscle on a nuclear scan five to 10 days later. The researchers found no difference between the two groups: The damage involved 10 percent of the left ventricle, on average, in the abciximab group and 9 percent of the left ventricle in the placebo group. In addition, the 30-day combined rates of death, heart attack, stroke and urgent repeat coronary procedures were similar in the two groups (5 percent and 3.8 percent, respectively).

"For patients with acute ST-elevation myocardial infarction undergoing primary coronary intervention after pre-treatment with a 600-mg loading dose of clopidogrel, the additional use of abciximab is not associated with any measurable benefit after 30 days," Dr. Mehilli said.

Dr. Mehilli will present the results of the BRAVE-3 study on Sunday, March 30 at 8:30 a.m. CDT in the Grand Ballroom, S100.

About SCAI

Headquartered in Washington, DC, the Society for Cardiovascular Angiography and Interventions is a 4,000-member professional organization representing invasive and interventional cardiologists in over 60 nations. SCAI's mission is to promote excellence in invasive and interventional cardiovascular medicine through physician education and representation, and advancement of quality standards to enhance patient care. SCAI's annual meeting has become the leading venue for education, discussion, and debate about the latest developments in this dynamic medical specialty.

About ACC

The American College of Cardiology is leading the way to optimal cardiovascular care and disease prevention. The College is a 34,000-member nonprofit medical society and bestows the credential Fellow of the American College of Cardiology upon physicians who meet its stringent qualifications. The College is a leader in the formulation of health policy, standards and guidelines, and is a staunch supporter of cardiovascular research. The ACC provides professional education and operates national registries for the measurement and improvement of quality care.


'/>"/>
SOURCE SCAI-ACCi2
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. Replikins LLC Finds West Nile Virus Replikin Count Has Reached Its Highest Recorded Value
2. Experts Call for Widespread Use of Memory Screenings and Emphasize Value of Early Detection of Dementia
3. TorreyPines Therapeutics Announces Strategic Plan with Focus on Clinical Development Activities to Maximize Value of Versatile Lead Compounds
4. Industry Executives Finding Value in Shift of Scientific Publications
5. Bertrand Study Finds Significant Value in Breast-Specific Gamma Imaging (BSGI) as an Adjunctive Procedure in Breast Diagnostics
6. Many Heart Attack Patients Dont Get Best Emergency Treatment
7. The Heart, Diabetes, And Weight Loss Centers of New York Introduce the New Science of Metabolic Diagnosis and Weight Management
8. American Heart Association Comment Saving Lives in Type 2 Diabetics: Could It Be as Easy as Lowering Blood Pressure?
9. Terumo Heart to Announce Results of European Clinical Trial of DuraHeart(TM) LVAS at European Association of Cardiothoracic Surgeons Meeting in September
10. WorldHeart Announces Further Milestone in Miniaturized Assist Pump Development
11. CellCyte Genetics Corp. Enters Collaborative Research Agreement With Cleveland Clinic Foundation to Qualify Stem Cell Delivery in Damaged Heart Tissue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)...  Eli Lilly and Company (NYSE: LLY ... EXPEDITION3 trial at the 9 th Clinical Trials ... did not meet the primary endpoint in the EXPEDITION3 ... with mild dementia due to Alzheimer,s disease (AD), and ... the treatment of mild dementia due to AD. ...
(Date:12/8/2016)... QUEBEC CITY , Dec. 8, 2016 /PRNewswire/ ... key US patents for improving the accuracy, reproducibility ... CD images in long and small bone orthopaedic ... proprietary approach to creating personalized orthopaedic restorations based ... create personalized orthopaedic restorations, the company harnesses the ...
(Date:12/8/2016)... , Dec. 8, 2016  EIP Pharma, ... has obtained proof-of-mechanism for neflamapimod (previously code named ... Phase 2a clinical trials that demonstrated significant Alzheimer,s ... 302 (12-week treatment) and Study 303 (6-week treatment) ... Trials in Alzheimer,s Disease (CTAD) scientific conference in ...
Breaking Medicine Technology:
(Date:12/9/2016)... ... December 09, 2016 , ... Flottman Company is ... As a means of expanding capabilities Flottman has added a G&K Vijuk ... code professional inserts (PIs) and patient package inserts (PPIs) that will marry with ...
(Date:12/9/2016)... ... 2016 , ... Mediaplanet today announces distribution of the latest edition of “Transplants,” ... up as an organ donor for the 123,000 people in the United States who ... save up to 8 saves through organ donation and enhance many others through tissue ...
(Date:12/8/2016)... ... December 08, 2016 , ... The West Virginia Medical ... 2017. The name change aligns the entire company with its existing Quality ... quality. , “We are very proud of the achievements associated with the West ...
(Date:12/8/2016)... ... December 08, 2016 , ... Seavest Healthcare ... owned by an affiliate of Seavest, has won a prestigious national healthcare real ... County ambulatory care center (ACC) was named “Best New Development, MOBs and Other ...
(Date:12/8/2016)... ... ... Premier Fitness Camp (PFC) and The Chopra Center for Wellbeing announced today the launch ... world headquarters of Omni La Costa Resort & Spa in San Diego. , Chopra ... personal development, a healthy lifestyle, or mental and physical healing. The week-long wellness program ...
Breaking Medicine News(10 mins):