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BRAVE-3 Questions Value of Abciximab in PCI for Heart Attack
Date:3/30/2008

With high-dose clopidogrel, the intravenous anti-platelet drug appears

unnecessary

CHICAGO, March 30 /PRNewswire/ -- Over the years, interventional cardiologists have made many improvements in percutaneous coronary intervention (PCI) for patients with heart attack, among the most important, refinements in the selection and administration of drugs that prevent unwanted blood clotting. Now a new study has found that high loading doses of clopidogrel, an oral medication that inhibits blood clots by preventing platelets from clumping together, can eliminate the need for intravenous abciximab, a standard cath-lab drug that also interferes with platelets, but through a different pathway.

The BRAVE-3 study is the first to test the influence of high-dose clopidogrel on the value of abciximab exclusively in patients with ST-elevation myocardial infarction (STEMI), a serious form of heart attack. The study is being reported today in a Late-Breaking Clinical Trials session at the SCAI Annual Scientific Sessions in Partnership with ACC i2 Summit (SCAI-ACCi2) in Chicago. SCAI-ACCi2 is a scientific meeting for practicing cardiovascular interventionalists sponsored by the Society for Cardiovascular Angiography and Interventions (SCAI) in partnership with the American College of Cardiology (ACC).

"Acute myocardial infarction is a major medical problem, and the present study will help to define the optimal treatment strategy," said Julinda Mehilli, MD, an associate professor and staff cardiologist at Deutsches Herzzentrum, Technical University, Munich, Germany. "Therapy without abciximab would certainly be more cost-effective and reduce the risk of bleeding complications."

For the study Dr. Mehilli and colleagues recruited 800 patients with STEMI who were undergoing PCI. All patients were pretreated with 600 mg of clopidogrel and then randomly assigned to receive intravenous abciximab or a placebo during the procedu
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SOURCE SCAI-ACCi2
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