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BN ImmunoTherapeutics Announces Positive Mature Phase II Results From Newly Acquired Prostate Cancer Vaccine
Date:10/7/2008

125 Patient, Prospective Randomized Placebo-Controlled Phase II Study Shows

Statistically Significant Improved Overall Survival.

MOUNTAIN VIEW, California, October 7 /PRNewswire/ -- BN ImmunoTherapeutics has now evaluated the mature Phase II data from the therapeutic prostate cancer vaccine candidate PROSTVAC(TM) that had been obtained as part of the recently entered partnership with the National Cancer Institute (NCI) in the US.

The results from the Phase II prospective randomized placebo-controlled study of 125 patients with advanced prostate cancer after 4 years of follow-up show that patients receiving PROSTVAC(TM) had a statistically significantly longer median overall survival by 8.5 months (p=0.015) compared to the control group. Currently the only approved treatment for advanced prostate cancer extends median overall survival by an average of approximately 2 months. In addition, PROSTVAC(TM) also had a favorable safety and tolerability profile.

Based on these promising results, BN ImmunoTherapeutics expects to initiate confirmatory Phase III studies for PROSTVAC(TM) together with the NCI in the first half of 2010 that will form the basis of approval for this therapy.

Prostate cancer is the most common form of cancer with more than 500,000 newly diagnosed patients globally per year and only limited treatment options. With estimated more than 140,000 related deaths annually, prostate cancer is the third leading cause of cancer related deaths in men.

Philip Kantoff MD, Professor of Medicine, Harvard Medical School, the principal investigator of the study, said "There are few available treatments for advanced prostate cancer. To see this extent of improvement in overall survival is very encouraging. These Phase II data with PROSTVAC(TM) warrant confirmation with a Phase III study and when confirmed this product has the potential to fulfill an unmet medical need for these patients."

Reiner Laus, President
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SOURCE BN ImmunoTherapeutics
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