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BD Rx Announces FDA Approval of High-Demand Injectable for Pain Management
Date:11/4/2013

stence, extent and course of intracranial pathology. Clinicians should maintain a high index of suspicion for adverse drug reactions when evaluating altered mental status or movement abnormalities in patients receiving this modality of treatment.

Hypotensive Effect
Morphine sulfate may cause severe hypotension in an individual whose ability to maintain their blood pressure has been compromised by a depleted blood volume, shock, impaired myocardial function or concurrent administration of sympatholytic drugs, and drugs such as phenothiazines or general anesthetics.  Orthostatic hypotension is a frequent complication in single-dose parenteral morphine analgesia in ambulatory patients.

The vasodilation produced by Morphine Sulfate Injection USP may further reduce cardiac output and blood pressure in patients in circulatory shock.

Gastrointestinal Effects
Do not administer Morphine Sulfate Injection USP to patients with gastrointestinal obstruction, especially paralytic ileus because Morphine Sulfate Injection USP diminishes propulsive peristaltic waves in the gastrointestinal tract and may prolong the obstruction.

The administration of Morphine Sulfate Injection USP may obscure the diagnosis or clinical course in patients with acute abdominal condition.

Use in Biliary Surgery or Disorders of the Biliary Tract
Morphine sulfate should be used with caution in patients with biliary tract disease, including acute pancreatitis, as morphine sulfate may cause spasm of the sphincter of Oddi and diminish biliary and pancreatic secretions.

Exposure, Hypothermia, Immersion and Shock
Caution must be used when injecting any opioid intramuscularly into chilled areas or in patients with hypotension or shock, since impaired perfusion may prevent complete absorption; if repeated injections are administered, an excessive amount may be suddenly absorbed if normal circulation is re-established.

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SOURCE BD (Becton, Dickinson and Company)
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