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Azor(TM) Reduces Blood Pressure in Difficult to Treat Special Populations
Date:5/15/2008

levels. For those patients with BMI greater than or equal to 30 kg/m(2), AZOR 10/40 mg demonstrated mean reductions of 30/18 mm Hg from an average baseline BP of 163/102 in the total cohort. Patients with BMI of less than 30 kg/m(2) saw BP reductions of 31/21 mm Hg when treated with AZOR 10/40 mg from an average baseline BP of 165/101 in total cohort.

DIABETES:

Patients with hypertension and diabetes are at greater risk of cardiovascular and renal disease and consequently have a more stringent recommended target BP goal of <130/80 mm Hg. Most patients require treatment with a combination of at least two antihypertensive agents in order to achieve their recommended goal BP, especially high-risk subgroups, and use of complementary antihypertensive drug classes is advocated in such patients.(15)(16)

Of the 1,940 patients who entered the eight week pivotal study, 261 had a medical history of diabetes. The data demonstrated the ability of AZOR to reduce blood pressure in the diabetes patient cohort. The diabetic patients treated with AZOR 10/40 mg were able to reduce their mean BP 30/18 mm Hg from an average baseline BP of 169/101 in the total cohort. This result was similar in comparison to patients without diabetes treated with AZOR 10/40 mg who were able to reduce their mean BP 30/19 mm Hg from an average baseline BP of 163/102 in the total cohort.

Important safety information

USE IN PREGNANCY

When used in pregnancy during the second and third trimesters, drugs that act directly on the renin-angiotensin system can cause injury and even death to the developing fetus. When pregnancy is detected, AZOR should be discontinued as soon as possible. See WARNINGS AND PRECAUTIONS, Fetal/Neonatal Morbidity and Mortality.

Hypotension in Volume- or Salt-Depleted Patients

In patients with an activated renin-angiotensin system, such as volume- and/or salt-depleted patients, symptomatic hypotension due particularly to the olmesa
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SOURCE Daiichi Sankyo, Inc.
Copyright©2008 PR Newswire.
All rights reserved

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