AviaraDx Confirms That Combination of Two Molecular Biomarkers Improves Prediction of Disease Recurrence in Early Stage Breast Cance... (oliferation genesignatures are essential...)

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AviaraDx Confirms That Combination of Two Molecular Biomarkers Improves Prediction of Disease Recurrence in Early Stage Breast Cancer Patients

Date:5/13/2008

oliferation gene signatures are essentially redundant, and they do not go beyond ER/PR in determining the likelihood of responding to endocrine therapy," said Antonius Schuh, PhD, chief executive officer of AviaraDx, Inc. "H/I and MGI together provide a more complete diagnostic picture that should help clinicians make more appropriate treatment decisions for their breast cancer patients."

"This is the first analysis linking H/I to our new, five-gene tumor grading index, MGI," said Mark Erlander, PhD, chief scientific officer for AviaraDx, Inc. "For patients whose tumors have high MGI values, it is important to measure H/I in order to determine likely benefit from endocrine therapy within the setting of a highly proliferating tumor."

The authors conclude that these two markers together should enable oncologists to identify a large subgroup of women with low risk of recurrence who may be spared from toxic chemotherapy regimens. In addition, they may also identify a significant population of patients for whom intensive chemotherapy regimens or new therapeutic agents should be considered.

"As molecular diagnostics enable the personalization of patient care, we will help patients and clinicians determine appropriate therapies and avoid both over- and under-treatment," added Schuh.

Approximately 100,000 women present with ER-positive, node-negative breast cancer in the United States every year. The data included in this month's Clinical Cancer Research publication show that the combination of Aviara MGI and Aviara H/I provides objective information to better assess both recurrence risk and potential for response to systemic therapies in these early stage breast cancer patients. The combination of these two biomarkers is now commercially available as the Aviara Breast Cancer Index(SM).

About AviaraDx, Inc.

AviaraDx discovers, develops, and commercializes new molecular diagnostic tests in oncology, enabling physicians to personalize
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