Navigation Links
AviaraDx Confirms That Combination of Two Molecular Biomarkers Improves Prediction of Disease Recurrence in Early Stage Breast Cancer Patients
Date:5/13/2008

derive varying degrees of benefit from chemotherapy, while patients with less aggressive, low grade (Grade 1) tumors usually derive no benefit. However, approximately 50 percent of all early stage breast cancer patients are diagnosed with an intermediate tumor grade (Grade 2). For these patients the appropriate choice of therapy is unclear. The clinical data published this month demonstrate that Aviara MGI accurately identifies Grade 1 and 3 tumors, and successfully re-classifies intermediate tumor grade (Grade 2) into cases with Grade 1-like or Grade 3-like outcomes.

"The importance of accurate tumor grading cannot be understated," said Dennis C. Sgroi, director of breast pathology at Massachusetts General Hospital and associate professor of pathology at Harvard Medical School, a senior author of the article. "A molecular tool such as MGI that can help separate intermediate-grade tumors into two distinct prognostic groups will go a long way in stratifying risk and improving treatment selection for breast cancer patients."

Researchers combined Aviara MGI and Aviara H/I in order to assess the overall impact of both molecular tumor grade and endocrine therapy benefit on patient outcome. H/I is a well-established biomarker that has been shown to predict both recurrence risk and endocrine benefit in more than 2,000 patients in numerous clinical studies. It assesses the likelihood of a patient to benefit from endocrine therapy by measuring the functionality of the estrogen signaling pathway inside the tumor cell itself. As such, H/I goes beyond conventional estrogen and progesterone receptor (ER/PR) testing. While patients who are ER/PR positive are assumed to benefit from endocrine therapy, the therapy fails in approximately 25 percent of those patients.

"Other gene-signature assays developed for breast cancer provide an improvement over tumor grade as a measure of breast cancer aggressiveness and likely benefit from chemotherapy. These different pr
'/>"/>

SOURCE AviaraDx, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. New Study Confirms Dose-Accuracy of SoloSTAR(R) Prefilled Insulin Pen
2. Interim Analysis of Phase I/II Study of Rexin-G Confirms Efficacy With No Dose Limiting Toxicity in Metastatic Pancreatic Cancer
3. FDA Confirms Seizure of Eyelash Product Was Not Prompted by Reports of Adverse Effects
4. New Data Confirms That a Selective, Fully Human Anti-VEGF Antibody Being Developed by Peregrine is as Effective as Avastin(R) in Preclinical Cancer Models
5. Study Confirms That New Protocol Shortens the Time It Takes to Open Blocked Arteries for Heart Attack Patients
6. IDM Pharma Announces Updated Phase 3 Mifamurtide (L-MTP-PE) Data Confirms Statistically Superior Overall Survival in Osteosarcoma Patients
7. Study Confirms Limited Human-To-Human Spread of Avian-Flu Virus in Indonesia in 2006
8. CryoLife Announces First Implant of Combination Aortic-Mitral Allograft Heart Valve at the Cleveland Clinic
9. Vion Pharmaceuticals Announces Initiation of Clinical Trial of Cloretazine(R) (VNP40101M) in Combination with Cytarabine
10. Amylin Pharmaceuticals Initiates Phase 2B Dose-Ranging Clinical Study of Pramlintide/Metreleptin Combination Treatment in Obesity
11. Dr. Calvin Grant Presents Results from Xibrom(TM) Combination Therapy with Lucentis(R) at the 2008 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 2015  ViewRay™, a privately held medical device company, announced ... agreement with ITOCHU Corporation (Tokyo Stock Exchange TYO: 8001) ... treatment of cancer in Japan . ... first and only MRI-guided radiation therapy system that images ...
(Date:1/22/2015)... (NASDAQ: AMGN ) today announced that it will report ... Jan. 27, 2015, after the close of the U.S. financial markets. ... investment community at 2 p.m. PT. Participating in the call from ... executive officer, and other members of Amgen,s senior management team. ...
(Date:1/22/2015)... , Jan. 22, 2015 Research and Markets ... addition of the "Microbiology Testing/Clinical Microbiology Market ... Global Forecast to 2019" report to their ... wide array of techniques for the detection of ...
Breaking Medicine Technology:ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2Amgen Announces Webcast of 2014 Fourth Quarter and Full Year Financial Results 2Global Microbiology Testing/Clinical Microbiology (Instrument, Analyzer, Incubator, Kit, Microscope, Molecular Diagnostics) Market - Forecast to 2019 2Global Microbiology Testing/Clinical Microbiology (Instrument, Analyzer, Incubator, Kit, Microscope, Molecular Diagnostics) Market - Forecast to 2019 3
... , FRANKLIN, Mass. , May 24 Arthrosurface, ... announced the achievement of a significant clinical milestone.  Over 20,000 patients, ... resurfacing systems, with the early patients now 6 years post surgery. ... "Back in ...
... At a town hall meeting a year ago, President Obama said that home-based ... people out of more expensive institutional care.  "I actually think homecare ends up ... people in their homes," the president told his audience in the Cleveland ... , , ...
Cached Medicine Technology:Arthrosurface® Hits the 20,000 Implant Milestone 2Medicare Policies Ignore Aging-at-Home Concept 2Medicare Policies Ignore Aging-at-Home Concept 3Medicare Policies Ignore Aging-at-Home Concept 4Medicare Policies Ignore Aging-at-Home Concept 5
(Date:1/22/2015)... 22, 2015 The federal court overseeing thousands ... District Court, Southern District of West Virginia has upheld a ... proceeding’s first bellwether trial. In an Order dated January 21st, ... after finding that C.R. Bard had not proven a miscarriage ...
(Date:1/22/2015)... Oceanside,CA (PRWEB) January 22, 2015 For over 20 ... the Oceanside and Vista area has treated just about ... other personal injury circumstances. And for those same twenty-plus years, ... victims of all those injuries with the best possible doctor. ...
(Date:1/22/2015)... has added many trendy Champagne wedding dresses to ... the past three years. Today, the business announces a special ... the sales manager of the company, this is on the ... point can be reflected on the discounted wedding dresses from ...
(Date:1/22/2015)... As interest in the value of spiritual support ... Rev. Eric J. Hall , president and CEO of ... be the keynote speaker on January 27 at an international ... , The conference, “Hope and Resilience: Innovative and Interdisciplinary Spiritual ...
(Date:1/22/2015)... 22, 2015 State Forestry Institute of ... system with support from GEOSYSTEMS, a dedicated Hexagon Geospatial ... will leverage Hexagon Geospatial’s ERDAS APOLLO for ... well as point clouds and documents. This effort will ...
Breaking Medicine News(10 mins):Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 3Health News:State Forestry Institute Mecklenburg-Vorpommern, Germany Embraces Hexagon Geospatial Technology 2Health News:State Forestry Institute Mecklenburg-Vorpommern, Germany Embraces Hexagon Geospatial Technology 3
... lost and becomes brittle, is one of the dreaded complications ... a result of decreased levels of estrogen, which is responsible ... of the University of Texas Medical Branch at Galveston, has ... may prevent bone loss after menopause as effectively as estrogen. ...
... women is on the rise. But the alarm bells are ... smokers with breast cancer face an increased risk of their ... nonsmokers ,"There is a relationship between smoking and ... MD, associate professor of medicine at the University of California ...
... libido, low motivation and fatigue, most often occurring in ... had been removed surgically for some reason. ,Dehydroepiandosterone(DHEA), ... dysfunction, according to a study released at the 96th ... California. This report was the end result of the ...
... Center reported in the current New England Journal of Medicine ... genes into six men suffering from hemophilia. This method ... producing the blood clotting protein they lack. None of ... the treatment. ,The study was designed only to test ...
... latest mantra of Pfizer. The pharmaceutical giant has announced ... hardest hit by the AIDS virus. The decision by the ... Government winning a landmark case against pharmaceutical companies. In ... Diflucan will be given free of cost to battle HIV ...
... Dr. Balakrishna Ganapat Rao Matapurkar, from Maulana Azad Medical ... winning the first patent on organ regeneration from the ... / repairing organs in human beings. ,A few ... patent on this technique. Dr. Matapurkar was able ...
Cached Medicine News:
... new system to help you meet the ... system's one-piece design creates a broad area ... radiographic assessment. The slotted superior and inferior ... column and are flared outward for greater ...
... With 36 joules delivered energy, the Atlas+ HF ... patient safety, programming flexibility, comfort, and quality of ... most powerful ICD offering cardiac resynchronization therapy (CRT), ... 81 gram and 40 cc physiologic-shaped can. In ...
... Intramedullary fixation has greatly ... tibial fractures. The Biomet Low ... indicated in the treatment of ... metastatic disease with pathologic or ...
... The Elite™ Premium Shoulder Instrument ... flexibility in arthroscopic and mini-open ... cuff and Bankart repair. Smith ... been designed to facilitate an ...
Medicine Products: