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Avastin Achieves Impressive Rate of Curative Surgery in Patients with Advanced Colorectal Cancer
Date:9/23/2007

- Largest Series of Patients with Successful Surgery Reported in Large,

Prospective Clinical Trial - Abstract no: 3020, Being Presented at ECCO in Room 115-116, Starting at

12:15 on Monday 24th September 2007

BARCELONA, Spain, Sept. 24 /PRNewswire/ -- New data from the large international First BEAT trial unveiled today at the European Cancer Conference (ECCO) demonstrate that a high number of patients treated with Avastin plus standard chemotherapy for their colorectal cancer underwent complete surgical removal of their metastatic lesions. Complete removal of metastatic lesions was achieved in almost 80% of these patients, all of whom had been considered inoperable prior to the start of treatment. This outcome with Avastin is higher than has been previously seen in trials with other biologics/chemotherapy combinations.

The First BEAT trial included 1,965 patients with advanced colorectal cancer with primarily inoperable metastatic disease. Patients received Avastin in combination with the commonly used fluoropyrimidine based chemotherapy regimens(i) as first line treatment and were assessed for their suitability for potentially curative surgery during the course of the treatment.

"The complete resection of metastatic lesions is the only option for cure in patients with metastatic colorectal cancer. Therefore these results represent a major step forward for the patient," said Dr Mondher Mahjoubi, Global Head Medical Affairs Oncology, Roche. "The high rates of successful, curative surgery achieved with Avastin plus standard chemotherapy are impressive, especially because First BEAT is a trial looking at a general, real life patient population."

First BEAT results presented at ECCO demonstrated that 215 (11.5%) of all patients included in the current data analysis (1,914) became eligible for and underwent surgery with curative intent during the course of treatment. Successful, complete rem
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SOURCE Roche
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