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Avanir Pharmaceuticals Announces Publication of 'PRISM' Pseudobulbar Affect Registry Findings
Date:8/22/2013

ished to provide PBA symptom prevalence data in a large, representative U.S. sample of patients in a clinical setting with neurological conditions known to be associated with PBA. A total of 5,290 patients were enrolled across 173 study sites, including 1,799 (34.0%) patients with Alzheimer's disease; 125 (2.4%) with amyotrophic lateral sclerosis (Lou Gehrig's disease), 1,215 (23.0%) with multiple sclerosis, 804 (15.2%) with Parkinson's disease, 757 (14.3%) with stroke, and 590 (11.2%) with traumatic brain injury.

About PBA
PBA is a neurologic condition characterized by emotional outbursts that are often contrary or exaggerated to the patient's inner mood state, causing them to laugh or cry uncontrollably. As a result, many of those afflicted with PBA show significant impairment on standard measures of health status, and disruption in occupational and social function, often leading to social isolation. PBA occurs secondary to a variety of neurologic conditions such as traumatic brain injury (TBI), multiple sclerosis (MS), Lou Gehrig's disease (ALS), Parkinson's disease, stroke and Alzheimer's disease. When these disorders damage areas of the brain that regulate normal emotional expression, they can lead to uncontrollable, disruptive episodes of crying or laughing. For more information about PBA, please visit www.pbafacts.com.

The CNS-LS has been validated in ALS and MS patients.

About Avanir Pharmaceuticals, Inc.
Avanir Pharmaceuticals, Inc. is a biopharmaceutical company focused on bringing innovative medicines to patients with central nervous system disorders of high unmet medical need. As part of our commitment, we have extensively invested in our pipeline and are dedicated to advancing medicines that can substantially improve the lives of patients and their loved ones. For more information about Avanir, please visit 

SOURCE Avanir Pharmaceuticals, Inc.
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11. AVANIR PHARMACEUTICALS ANNOUNCES RESEARCH COLLABORATION WITH DEPARTMENT OF VETERANS AFFAIRS FOR SCREENING PSEUDOBULBAR AFFECT (PBA) SYMPTOMS IN VETERANS WITH TRAUMATIC BRAIN INJURY
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