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Avanir Pharmaceuticals Announces Publication Of PBA Burden Of Illness Study
Date:9/5/2012

ment (WPAI) Questionnaire: General Health V2.0
  • The Center for Epidemiologic Studies Depression Scale 10-item short form (CES-D10)
  • The Screen for Caregiver Burden (SCB)
  • The PBA group reported significantly worse scores versus non-PBA controls on the SF-36 health survey (P < 0.05 for all physical and mental component and summary scores), QOL and QOR visual analog scales (P < 0.05 for both), and workplace productivity items (P ≤ 0.05). Most patients in the PBA group and over half in the control group had significant depressive symptoms as determined by a CES-D10 scale score of 10 or greater (87% PBA group vs. 56% controls; P < 0.05). PBA symptoms contributed a great deal or were the main cause of becoming housebound for 24% and placement in supervised living for 9% of PBA group respondents. In addition, caregiver burden prevalence and distress scores were higher among caregivers in the PBA group (13.7 and 41.5, respectively; P = 0.05) compared with the control group (10.2 and 37.6, respectively; P = 0.05).

    This study found that patients and primary caregivers of patients with PBA symptoms suffer significantly increased burden of illness compared with patients and caregivers of patients with the same underlying neurological conditions but without PBA symptoms. PBA group patients showed significantly greater impairment on measures of general health status, occupational and social function, and a significantly higher incidence of depressive symptoms than controls, both across and within primary neurological disease groups.  Inappropriate laughing/crying episodes were associated with feelings of embarrassment, frustration, and the potential for withdrawal and isolation.

    About Pseudobulbar Affect
    People with pseudobulbar affect (PBA) have sudden outbursts of involuntary crying or laughing, even though there may not be anything particularly sad or funny to trigger those emotions. Many people who suffer
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    SOURCE Avanir Pharmaceuticals, Inc.
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