Navigation Links
Avanir Pharmaceuticals Announces Presentation of Positive Early Results from PRISM II Study
Date:7/16/2014

lly consistent with that observed in other trials of NUEDEXTA. 

About PRISM II
The objectives of the study are to evaluate the safety, tolerability, and effectiveness of NUEDEXTA capsules containing 20 mg dextromethorphan (DM) and 10 mg quinidine (Q) for treatment of PBA in patients with prevalent neurological conditions including Alzheimer's disease/dementia, stroke and traumatic brain injury over a 12 week period.

PRISM II is a nationwide, open-label, multicenter, 12-week study enrolling up to approximately 450 patients at approximately 100 study centers. Eligible patients are aged >18 years with a clinical diagnosis of PBA and baseline score >13 on the Center for Neurologic Study-Lability Scale (CNS-LS). Patients with TBI due to a penetrating head injury are excluded. Patients are treated with NUEDEXTA mg twice daily. The primary endpoint is change from baseline in scores measured by the CNS-LS, a PBA rating instrument originally validated in patients with PBA secondary to ALS and MS. Determination of effectiveness is based on a comparison of CNS-LS change in PRISM II with results of previous phase III studies. Additional outcomes measures include: number of weekly PBA episodes (laughing and/or crying); Mini-Mental State Examination; quality of life; Clinician and Patient Global Impression of Change (CGIC; PGIC); patients' satisfaction with treatment; Patient Health Questionnaire (PHQ-9) (to evaluate mood symptoms), and the Neurobehavioral Functioning Inventory for TBI patients. Safety measures include monitoring of adverse events, concomitant medication usage, and vital signs.

Poster Presentation Details:
Title: PRISM II: An Open-Label Study to Assess the Safety, Tolerability, and Effectiveness of Dextromethorphan 20 mg/Quinidine 10 mg (NUEDEXTA) in Pseudobulbar Affect  (PBA) Secondary to Dementia, Stroke, or Traumatic Brain Injury (TBI): Early Results of the Alzheimer's Disease/Dementia Cohort'/>"/>

SOURCE Avanir Pharmaceuticals, Inc.
Copyright©2014 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Avanir Pharmaceuticals Pre-announces Preliminary Fiscal 2014 First Quarter Financial Information
2. Avanir Pharmaceuticals to Present at J.P. Morgan 32nd Annual Healthcare Conference
3. Quarterly Dividends, Clinical Trial Results, Dental Exhibition Updates, and Upcoming Presentation Schedules - Research Report Quest Diagnostics, Avanir, Sirona, Ligand and Genomic Health
4. Avanir Pharmaceuticals Reports Fiscal 2013 Fourth Quarter Financial and Year-End Business Results
5. Avanir Pharmaceuticals Announces Results for Phase II PRIME Study
6. Preliminary Financial Results, Quarterly Reports and Upcoming Conference Schedules - Research Report on Avanir, BioScrip, Chemed, Foundation Medicine, and Antares
7. Avanir Pharmaceuticals Pre-Announces Preliminary Fiscal 2013 Year End Financial Information
8. Avanir Pharmaceuticals to Host Investor Day on October 29, 2013
9. Avanir Pharmaceuticals Announces Enrollment of First Patient in Study of AVP-923 for the Treatment of Levodopa Induced Dyskinesia in Parkinsons Disease
10. Avanir Pharmaceuticals Announces Publication of AVP-825 Pharmacokinetic Data in Journal "Headache"
11. Avanir Pharmaceuticals Announces Settlement of NUEDEXTA Patent Litigation with Wockhardt
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... , Jan. 23, 2015  CytoSorbents Corporation (NASDAQ CM: ... CytoSorb® extracorporeal cytokine adsorber to reduce deadly inflammation ... receipt of $385,642, net of transaction costs, in ... Technology Business Tax Certificate Transfer Program sponsored by ...
(Date:1/23/2015)... CHENGDU, China , Jan. 23, 2015 Tianyin ... pharmaceutical company that specializes in the development and sale ... branded generics and active pharmaceutical ingredients (API) today announced ... Facility (JCM) API operation. 1. Following the ...
(Date:1/22/2015)... (NYSE: RMD ) today announced results for its ... $423.0 million, a 10 percent increase compared to the quarter ... constant currency basis). Net income was $91.2 million, an increase ... 2013. Diluted earnings per share for the quarter were $0.64, ...
Breaking Medicine Technology:CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 3TPI's JCM Updates on Import Registration for International Clients 2TPI's JCM Updates on Import Registration for International Clients 3TPI's JCM Updates on Import Registration for International Clients 4ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 2ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 3ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 4ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 5ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 6ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 7ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 8ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 9ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 10ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 11
... Physician,s Computer Company (PCC) – a Vermont pediatric software ... the updated 5010 transaction standard for electronic claims and ... readiness among its payers. An ICD-10/5010 Readiness ... Management Systems Society (HIMSS), indicates an estimated 1/3 of ...
... NORTH CANTON, Ohio, April, 19th 2011 On Thursday, April ... session on "Safe and Effective Disinfection" at Starline Supply Company,s ... http://photos.prnewswire.com/prnh/20110412/CL80582LOGO-b ) S pe ... partner with Starline Supply who are dedicated to having a ...
Cached Medicine Technology:PCC Frustrated with Payers' Lack of 5010 Readiness 2The SpectraSan 24™ Team to be the Featured Disinfection Presenter at Starline Supply Company's Customer Appreciation Day 2The SpectraSan 24™ Team to be the Featured Disinfection Presenter at Starline Supply Company's Customer Appreciation Day 3
(Date:1/22/2015)... (PRWEB) January 22, 2015 The federal court ... the U.S. District Court, Southern District of West Virginia has ... in that proceeding’s first bellwether trial. In an Order dated ... new trial after finding that C.R. Bard had not proven ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Thousand of ... Medical Care recalled its GranuFlo and NaturaLyte dialysis concentrates ... underway in U.S. District Court, District of Massachusetts, Bernstein ... 20th, the Court has remanded a case filed by ...
(Date:1/22/2015)... 22, 2015 Carinsurancesavings.biz has released a new ... and dismemberment insurance . , Purchasing an accidental death ... very advantageous. This type of rider provides benefits if the ... be considered a lesser form of life insurance. , ...
(Date:1/22/2015)... Jolla, Calif. (PRWEB) January 22, 2015 ... Assemblymembers Susan Bonilla (D-Concord) and Kristin Olsen (R-Modesto) ... for their leadership in advancing biotechnology, biomedical science, ... Bonilla and Olsen each received the “2014 Life ...
(Date:1/22/2015)... Boulder, Colorado (PRWEB) January 22, 2015 Four years ... is Queen – which coincided with the marriage of Avasa & ... album, THE ROAD, which is scheduled for release through White Swan ... heartfelt message that there is a sacred path available to all ...
Breaking Medicine News(10 mins):Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4
... Frank J. Weaver Award Recognizes ,Outstanding Contributions to the ... CareerWASHINGTON, May 19 The Public Relations Society of ... announced that Nancy Hicks has received the PRSA Health ... of her 25 years of exemplary client work and ...
... scientists have shown what the food poisoning bug Salmonella ... , Their discovery of Salmonella ,s weakness for ... The discovery could also lead to vaccine strains to protect ... the first time that anyone has identified the nutrients that ...
... Updates Television Infrastructure to Enable System Turn-On At ... S.D., May 19 LodgeNet Healthcare, a division ... ) and the leading provider of interactive patient ... Patient Television System is now serving patients at ...
... Leadership Needed to Focus Policy Actions at the Federal ... World Hepatitis Day, more than 200 viral hepatitis groups ... raise global awareness, and calling for international and national ... for people living with chronic viral hepatitis B and ...
... 19 "Federal law stipulates that the Department of ... the benefits they have earned by virtue of their ... Rowan, National President of Vietnam Veterans of America (VVA). ... that the VA inform veterans -- and the healthcare ...
... MADISON, N.J., May 19 Quest Diagnostics Incorporated (NYSE: ... information and services, announced today that it has commenced a ... principal amount (the "Tender Cap") of its 5.125% Senior Notes ... "Notes"). The terms and conditions of the tender offer are ...
Cached Medicine News:Health News:Ketchum's Nancy Hicks Honored with PRSA Health Academy's Lifetime Achievement Award 2Health News:Ketchum's Nancy Hicks Honored with PRSA Health Academy's Lifetime Achievement Award 3Health News:Ketchum's Nancy Hicks Honored with PRSA Health Academy's Lifetime Achievement Award 4Health News:Salmonella's sweet tooth predicts its downfall 2Health News:LodgeNet Healthcare Announces Deployment of Interactive Patient Television System in Oklahoma Heart Hospital 2Health News:LodgeNet Healthcare Announces Deployment of Interactive Patient Television System in Oklahoma Heart Hospital 3Health News:National Viral Hepatitis Roundtable Observes World Hepatitis Day and Calls for Increased Federal Action 2Health News:National Viral Hepatitis Roundtable Observes World Hepatitis Day and Calls for Increased Federal Action 3Health News:VA Needs Legislative Push to Inform Veterans of Health Issues Connected to Military Service 2Health News:Quest Diagnostics Commences Cash Tender Offer for Up to $200 Million Aggregate Principal Amount of Certain of its Outstanding Notes 2Health News:Quest Diagnostics Commences Cash Tender Offer for Up to $200 Million Aggregate Principal Amount of Certain of its Outstanding Notes 3Health News:Quest Diagnostics Commences Cash Tender Offer for Up to $200 Million Aggregate Principal Amount of Certain of its Outstanding Notes 4
... enables hospitals to standardize ... to a single temperature ... monitoring disposale probes and ... in their manufacture and ...
... The pause of a heartbeat. The ... of rhythmic breathing. These vital signs are ... check. DeRoyals line of Temperature Monitoring products ... the information needed to provide the most ...
... The pause of a heartbeat. The ... of rhythmic breathing. These vital signs are ... check. DeRoyals line of Temperature Monitoring products ... the information needed to provide the most ...
... stabilization of the capsular bag in complicated ... Tension Ring has application in several different ... available for patients with pseudoexfoliation syndrome. Many ... tension ring, especially those in whom you ...
Medicine Products: