Navigation Links
Avanir Pharmaceuticals Announces Initiation of Phase II Study of AVP-786 for the Adjunctive Treatment of Major Depressive Disorder
Date:8/26/2014

gly utilized in central nervous system (CNS) clinical trials. This study design is intended to reduce placebo response rates, a phenomenon commonly observed in depression trials.  The primary efficacy measure is the Montgomery-Asberg Depression Rating Scale (MADRS) total score, a standard clinical measure of depression. Secondary outcome measures include assessments of disease severity, activities of daily living, and quality of life. Pharmacokinetics and standard safety assessments will also be conducted.

Update on the Agitation in Alzheimer's Disease Patients Study
The company expects to announce top-line results from the Agitation in Alzheimer's disease study in late September/early October 2014. The objectives of this proof of concept study are to evaluate the safety, tolerability, and efficacy of AVP-923 for the treatment of agitation in Alzheimer's patients. The trial is a 10-week, multicenter, randomized, double-blind, placebo-controlled study utilizing a SPCD design intended to reduce placebo response rates. Enrollment was completed with 220 Alzheimer's patients in the United States. Eligible patients were initially randomized 3:4 to receive either AVP-923 (dose escalated from DM 20mg/ Q 10mg to DM 30mg/ Q 10mg) or placebo. At the end of week five, patients who initially received placebo were stratified according to their response to treatment and subsequently re-randomized 1:1 to receive either AVP-923 or placebo for the remainder of the study (an additional 5 weeks of treatment). Patients who initially received AVP-923 continued to receive AVP-923 DM 30mg/ Q 10mg for the remainder of the study. The main efficacy measure is the agitation/aggression subscale of the Neuropsychiatric Inventory or NPI. The primary endpoint follows a standard analysis of SPCD by combining the change from baseline to week 5 (full analysis population) and change from week 5 to week 10 on the NPI agitation/aggression domain (patients who we
'/>"/>

SOURCE Avanir Pharmaceuticals, Inc.
Copyright©2014 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Avanir Pharmaceuticals Reports Fiscal 2014 Third Quarter Financial and Business Update
2. Avanir Pharmaceuticals to Participate in Two Conferences in August
3. Avanir Pharmaceuticals Announces FDA Acceptance of IND for AVP-786 for the Adjunctive Treatment of Major Depressive Disorder
4. Avanir Pharmaceuticals Announces Presentation of Positive Early Results from PRISM II Study
5. Avanir Pharmaceuticals Pre-announces Preliminary Fiscal 2014 First Quarter Financial Information
6. Avanir Pharmaceuticals to Present at J.P. Morgan 32nd Annual Healthcare Conference
7. Quarterly Dividends, Clinical Trial Results, Dental Exhibition Updates, and Upcoming Presentation Schedules - Research Report Quest Diagnostics, Avanir, Sirona, Ligand and Genomic Health
8. Avanir Pharmaceuticals Reports Fiscal 2013 Fourth Quarter Financial and Year-End Business Results
9. Avanir Pharmaceuticals Announces Results for Phase II PRIME Study
10. Preliminary Financial Results, Quarterly Reports and Upcoming Conference Schedules - Research Report on Avanir, BioScrip, Chemed, Foundation Medicine, and Antares
11. Avanir Pharmaceuticals Pre-Announces Preliminary Fiscal 2013 Year End Financial Information
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... Today Eli Lilly and Company (NYSE: LLY ... to increase the global supply of medicines for multidrug-resistant ... donating manufacturing technology and know-how for two antibiotics to ... India , Russia ... MDR-TB ,hot spots., It also served as the foundation ...
(Date:10/27/2014)... Research and Markets has announced the addition of ... their offering. H1N1 influenza (zoonotic) is an ... swine H1N1 virus, known as H1N1v virus. The H1N1v virus ... H1N1 virus is an RNA virus belonging to the Orthomyxoviridae ... humans, swine, birds, seals, and horses. Influenza A viruses can ...
(Date:10/27/2014)... EAST TAUNTON, Mass. , Oct. 27, 2014 /PRNewswire/ ... the $15 billion global hip and knee replacement device market, ... and knee replacement technology at the American Association of ... the Sheraton Dallas Hotel in Dallas, Texas ... is a Bronze corporate partner of the organization. ...
Breaking Medicine Technology:Lilly Shares Insights from Decade-Long Technology Transfer Experience 2Lilly Shares Insights from Decade-Long Technology Transfer Experience 3Lilly Shares Insights from Decade-Long Technology Transfer Experience 4Global H1N1 Vaccines Market 2014-2018: Key Vendors are AstraZeneca, GlaxoSmithKline, Novartis and Sanofi Pasteur 2Global H1N1 Vaccines Market 2014-2018: Key Vendors are AstraZeneca, GlaxoSmithKline, Novartis and Sanofi Pasteur 3OMNIlife science to Exhibit at American Association of Hip and Knee Surgeons 24th Annual Meeting in Dallas November 6-9 2OMNIlife science to Exhibit at American Association of Hip and Knee Surgeons 24th Annual Meeting in Dallas November 6-9 3
... , LAKE FOREST, Ill. , Jan. 12 ... of injectable pharmaceuticals announced today the launch of Ibutilide ... from Pfizer Inc. , (Logo:   http://www.newscom.com/cgi-bin/prnh/20080702/AQW070LOGO ) , ... Pharma,s continued growth and dedication to a consistently expanding ...
... Jan. 12 CVS Caremark Corporation (NYSE: CVS ) ... quarterly dividend of approximately 15%, to 8.75 cents per share on ... holders of record on January 22, 2010 . This increase translates into ... cents per share from the previous rate of 30.5 cents . ...
Cached Medicine Technology:Bioniche Pharma Launches Ibutilide Fumarate Injection 2CVS Caremark Corporation Increases Quarterly Dividend 15% 2
(Date:10/30/2014)... Timothy, InstaKNOT’s 4-year-old CEO, plans ... that you are never too young to give back ... and Carl at the 2013 Santa Arriving By Helicopter ... Chamber of Commerce. Tracey gave Timothy a special tour ... his real fireman’s hat, and extending an offer to ...
(Date:10/30/2014)... PreDiabetes Centers , the pioneer ... shoppers with a supply of sugardown®, a chewable dietary ... blood sugar spikes. Learning how to control blood sugar ... of a diabetes prevention plan. , Shoppers who spend ... tube of sugardown. The offer expires November 30. ...
(Date:10/30/2014)... Dennis Thompson HealthDay ... The Ebola outbreak in Liberia -- one of three West ... World Health Organization officials said Wednesday. Dr. Bruce Aylward, ... the number of burials in Liberia and no increase in ... global push to tame the epidemic may be making some ...
(Date:10/30/2014)... (PRWEB) October 30, 2014 ... Commission Accredited teleradiology and specialty telemedicine solutions provider, ... addition to its existing teleradiology services at Mission ... opinion and expert telemedicine services, to the state-of-the-art, ... As a result of this innovative partnership, there ...
(Date:10/30/2014)... Sound Telecom, a leader in the call ... people any time they wonder, “Should I use an answering ... leading them through a series of yes or no questions ... , There are many considerations and scenarios that come into ... answering service . This decision infographic serves as a bit ...
Breaking Medicine News(10 mins):Health News:4-year-old InstaKNOT CEO Honors Local Firefighters with Community Support 2Health News:4-year-old InstaKNOT CEO Honors Local Firefighters with Community Support 3Health News:4-year-old InstaKNOT CEO Honors Local Firefighters with Community Support 4Health News:PreDiabetes Treatment Company Offers PreD Store Shoppers Supplements to Support Healthy Blood Sugar 2Health News:Ebola Outbreak in Liberia May Be Slowing: WHO 2Health News:Ebola Outbreak in Liberia May Be Slowing: WHO 3Health News:USARAD HOLDINGS INC, SECONDOPINIONS.COM® Pioneers Specialty On-Demand Telemedicine And Second Opinion Service At Houston-Based, Mission Bend Freestanding ER Chain 2Health News:USARAD HOLDINGS INC, SECONDOPINIONS.COM® Pioneers Specialty On-Demand Telemedicine And Second Opinion Service At Houston-Based, Mission Bend Freestanding ER Chain 3Health News:Sound Telecom Produces Decision Infographic to Aid Businesses 2
... ... to Walk with Style , ... Portland, OR (PRWEB) March 31, 2010 -- Pat Heyward Canes, a new provider of fashion ... designer patterns for men and women ranging from classic to whimsical. Made from performance ...
... ... efforts , ... Lake City, UT (Vocus) March 31, 2010 -- Venafi, Inc. ( www.venafi.com ) today ... when encryption keys are not properly monitored and managed., , ,Visit this link to ...
... ... for its innovative work in bringing about positive, scalable community-led change in thousands of ... ... named nonprofit Tostan as a 2010 recipient of its prestigious Skoll ...
... believed to bear fruit that ripened into a living baby ... as new treatments for osteoporosis, the bone-thinning disease. That,s the ... of Natural Products . Young Ho Kim and ... affecting up to 6 million women and 2 million men ...
... popular imaging procedures such as virtual colonoscopy , WEDNESDAY, ... imaging technologies are exposing Americans to too much radiation ... U.S. Food and Drug Administration concludes two days of ... increase the safety of these procedures. , Specifically, the ...
... ... Deliver Critical Support for Users of Chemicals , ... Vancouver, WA and Tampa, FL (PRWEB) March 31, 2010 ... ChemTel, Inc., the nation’s premiere emergency response support center, are pleased to announce a ...
Cached Medicine News:Health News:Pat Heyward Canes Unveils New Stylish Walking Cane Collection Just in Time for Mother's Day 2Health News:PCI Compliance and Data Security Requires Private Key Management – New Industry White Paper Explains 2Health News:Tostan and Molly Melching Receive 2010 Skoll Award for Social Entrepreneurship 2Health News:Tostan and Molly Melching Receive 2010 Skoll Award for Social Entrepreneurship 3Health News:Tostan and Molly Melching Receive 2010 Skoll Award for Social Entrepreneurship 4Health News:FDA Hears Views on Risks of High Tech Scanners 2Health News:FDA Hears Views on Risks of High Tech Scanners 3Health News:FDA Hears Views on Risks of High Tech Scanners 4Health News:Safetec and ChemTel Announce Partnership 2Health News:Safetec and ChemTel Announce Partnership 3
... The pause of a heartbeat. The bodys ... rhythmic breathing. These vital signs are yours ... DeRoyals line of Temperature Monitoring products helps ... information needed to provide the most comfortable ...
... Excilite- is a portable, compact, lightweight ... capable of emitting the same intensity (50 ... on a smaller treatment area (30 cm). ... order to satisfy the most demanding professional ...
... system used in neurophysiology for studying evoked potentials. ... and/or the duration of the stimulus as well ... emission in an ongoing manner by acting on ... include the high repeatability of the impulses, the ...
... 1.0 is a high power pulsed ... response to pain, even in the ... differs from the other laser devices ... full safety, all the 3 laser ...
Medicine Products: