Navigation Links
Avanir Pharmaceuticals Announces Initiation of Phase II Study of AVP-786 for the Adjunctive Treatment of Major Depressive Disorder
Date:8/26/2014

gly utilized in central nervous system (CNS) clinical trials. This study design is intended to reduce placebo response rates, a phenomenon commonly observed in depression trials.  The primary efficacy measure is the Montgomery-Asberg Depression Rating Scale (MADRS) total score, a standard clinical measure of depression. Secondary outcome measures include assessments of disease severity, activities of daily living, and quality of life. Pharmacokinetics and standard safety assessments will also be conducted.

Update on the Agitation in Alzheimer's Disease Patients Study
The company expects to announce top-line results from the Agitation in Alzheimer's disease study in late September/early October 2014. The objectives of this proof of concept study are to evaluate the safety, tolerability, and efficacy of AVP-923 for the treatment of agitation in Alzheimer's patients. The trial is a 10-week, multicenter, randomized, double-blind, placebo-controlled study utilizing a SPCD design intended to reduce placebo response rates. Enrollment was completed with 220 Alzheimer's patients in the United States. Eligible patients were initially randomized 3:4 to receive either AVP-923 (dose escalated from DM 20mg/ Q 10mg to DM 30mg/ Q 10mg) or placebo. At the end of week five, patients who initially received placebo were stratified according to their response to treatment and subsequently re-randomized 1:1 to receive either AVP-923 or placebo for the remainder of the study (an additional 5 weeks of treatment). Patients who initially received AVP-923 continued to receive AVP-923 DM 30mg/ Q 10mg for the remainder of the study. The main efficacy measure is the agitation/aggression subscale of the Neuropsychiatric Inventory or NPI. The primary endpoint follows a standard analysis of SPCD by combining the change from baseline to week 5 (full analysis population) and change from week 5 to week 10 on the NPI agitation/aggression domain (patients who we
'/>"/>

SOURCE Avanir Pharmaceuticals, Inc.
Copyright©2014 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Avanir Pharmaceuticals Reports Fiscal 2014 Third Quarter Financial and Business Update
2. Avanir Pharmaceuticals to Participate in Two Conferences in August
3. Avanir Pharmaceuticals Announces FDA Acceptance of IND for AVP-786 for the Adjunctive Treatment of Major Depressive Disorder
4. Avanir Pharmaceuticals Announces Presentation of Positive Early Results from PRISM II Study
5. Avanir Pharmaceuticals Pre-announces Preliminary Fiscal 2014 First Quarter Financial Information
6. Avanir Pharmaceuticals to Present at J.P. Morgan 32nd Annual Healthcare Conference
7. Quarterly Dividends, Clinical Trial Results, Dental Exhibition Updates, and Upcoming Presentation Schedules - Research Report Quest Diagnostics, Avanir, Sirona, Ligand and Genomic Health
8. Avanir Pharmaceuticals Reports Fiscal 2013 Fourth Quarter Financial and Year-End Business Results
9. Avanir Pharmaceuticals Announces Results for Phase II PRIME Study
10. Preliminary Financial Results, Quarterly Reports and Upcoming Conference Schedules - Research Report on Avanir, BioScrip, Chemed, Foundation Medicine, and Antares
11. Avanir Pharmaceuticals Pre-Announces Preliminary Fiscal 2013 Year End Financial Information
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... CHAPEL HILL, N.C. , May 22, 2015 ... is critical to pharmaceutical brand recognition and success. ... Practices, LLC conducted a study to provide pharmaceutical ... level of investment (FTEs and budget) that are ... companies. Pharmaceutical and biotech marketing managers can utilize ...
(Date:5/22/2015)... May 22, 2015 The leading companies ... billion global cardiac rhythm management device market dominate ... that Medtronic, St. Jude Medical, Boston Scientific and ... this market segment. The healthcare market research publisher,s ... uses 2015 as a base year, providing forecasts ...
(Date:5/22/2015)... OF PRUSSIA, Pa. , May 22, 2015  The ... Behring its 2015 Corporate Leadership Award as recognition for ... improving the care of the bleeding disorders community.  The award ... Director, CSL Limited, during the NHF Annual Spring Soiree in ... "The National Hemophilia Foundation is dedicated to finding ...
Breaking Medicine Technology:Effective Marketing Services Group Critical for Pharmaceutical Brand Recognition 2Kalorama: Top Companies Dominate Cardiac Defibrillator Market 2Kalorama: Top Companies Dominate Cardiac Defibrillator Market 3Kalorama: Top Companies Dominate Cardiac Defibrillator Market 4National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 2National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 3National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 4
... 2012 The American Pharmacists Association (APhA), a DC-based, ... of pharmacy, announced that on Monday evening, May ... was attacked and defaced by an unknown individual ... ) APhA considers any attack ...
... the House passed H.R. 5651, its version of the ... provisions to mitigate drug shortages, most notably mandating an ... largest professional society concerned with the causes and treatment ... specialize in blood cancers such as leukemia, lymphoma, and ...
Cached Medicine Technology:American Society of Hematology Statement on House Passage of Prescription Drug User Fee Act (PDUFA) 2
(Date:5/22/2015)... 2015 Hands On HealthCare Massage Therapy ... the Annual One Day Sale on Massage and ... HCMT offers drastically reduced certificates one day a year. This ... sessions, through what used to be the slowest time of ... community as well. This once a year occurrence has become ...
(Date:5/22/2015)... (PRWEB) May 22, 2015 Family, friends, ... Hospital’s world-renowned surgical oncologist, Dr. LaSalle D. Leffall, on ... The luncheon began after Grand Rounds in the hospital’s ... waited anxiously outside the auditorium, trying to keep the ... but if he sees me, he’ll know something is ...
(Date:5/22/2015)... Coordinating care for people with complex, ... have not been reimbursed or rewarded for care ... has paved the way by offering reimbursement for ... of Oculus Health , an innovative care ... platform will now be able to easily engage ...
(Date:5/22/2015)... According to a new Aegis Living Study on Attitudes ... to worry about what will happen to their memory as ... Silent Generation), which may help explain why nearly half of ... Millennials (47%), Gen X’ers (51%), and Boomers (43%). The study ... more than 2,000 U.S. adults ages 18+. , “This ...
(Date:5/22/2015)... Coco Libre, the Official Coconut Water of ... at the 104th running of the race. On Sunday, May ... 315 people in one hour—one person about every 10 seconds. ... true to the heart of the Bay Area, so unique, ... to the finish line only made sense,” said Jennifer Goodrum, ...
Breaking Medicine News(10 mins):Health News:Hands On HealthCare Massage Therapy & Wellness Day Spa Announces Their Eighth Annual One Day Sale on Gift Certificates Will Take Place on June 17, 2015 2Health News:Hands On HealthCare Massage Therapy & Wellness Day Spa Announces Their Eighth Annual One Day Sale on Gift Certificates Will Take Place on June 17, 2015 3Health News:Colleagues Surprise Dr. LaSalle Leffall with 85th Birthday Celebration 2Health News:Oculus Health Care Coordination Platform Officially Launched 2Health News:Oculus Health Care Coordination Platform Officially Launched 3Health News:Oculus Health Care Coordination Platform Officially Launched 4Health News:New Study Reveals America’s Fear of Aging 2Health News:New Study Reveals America’s Fear of Aging 3Health News:Coco Libre Ice Luge Sets New World Record at Bay to Breakers 2
... have found that obese persons are at higher risk as ... ,Multiple myeloma or Kahler's disease is a type of ... bone marrow that produce antibodies. Its prognosis, despite therapy, is ... transplant. ,The joint study was conducted by a ...
... with a form of leukaemia boosts their chances of survival ... published in next Saturday's Lancet. ,In general, ... survival -- about 80 percent today, compared with only 10 ... drops significantly in infants aged under 12 months, where it ...
... went a little wild at a club. ,The ... in Bucharest, Romania after a gig and spent a whopping amount ... girls in his party so he reportedly asked where the women ... most expensive beverages and a group of girls who arrived after ...
... revealed that the reason behind her battle with Insomnia is her ... she is struggling with the sleep disorder, because her songs keep ... most of her lyrics and hits strike her when she's trying ... has to write them down or record them on the spot, ...
... has created history by successfully conducting a unrelated bone ... the cord blood cells from an American donor, at ... ,Howard Kafeero from Uganda suffered from Fanconi ... fatal. Seven months ago, he was brought to the ...
... raise awareness of maritime pollution and secure a place in ... the Pacific Ocean from San Francisco on Thursday. ... in her lightweight 24-foot (seven meter) silver rowing boat and ... kilometer) trek across the vast expanse of the Pacific. ...
Cached Medicine News:Health News:Obesity, a Risk Factor for Developing Multiple Myeloma 2Health News:Chennai Hospital Conducts Bone Marrow Transplantation Successfully 2Health News:Briton Set for Pacific Solo Odyssey to Highlight Warming 2
A quarter-vision dispensing case or table with a 6" high glass display area and halogen lights. Based on size of case, enjoy either 4, 5.5, 7 or 8 square feet respectively of elegant shelf space for ...
Hoya Vision Care is focused on providing the best available most technically advanced and highest quality eye care products and services to the dispensing optometrist, ophthalmologist and optician....
Danker Laboratories, Inc. combines a half-century of innovative manufacturing experience with state-of-the-art precision lathe equipment to provide the highest quality rigid gas permeable (RGP) conta...
... Eyebank Database is a multi-page database that ... used by the Eye Bank Association of ... and recipient information, laboratory and specular microscopy ... adverse reaction reports, letters and invoices that ...
Medicine Products: