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Avanafil Data to be Presented at the Sexual Medicine Society of North America Meeting
Date:11/10/2011

son with sildenafil, tadalafil and vardenafil. Dr. Wang concludes that, in-vitro, avanafil was the most selective PDE5i for all the eleven PDE isozymes.  

Lastly, John Mulhall, MD, Director of the Male Sexual and Reproductive Medicine Program at the Memorial Sloan Kettering Cancer Center in New York, will present a poster entitled:

A  Phase III, Placebo-Controlled Study of the Safety and Efficacy of Avanafil in the Treatment of Erectile Dysfunction Following Nerve-Sparing Radical ProstatectomyIn his presentation, Dr. Mulhall will summarize the safety and efficacy results of the phase 3, randomized study of avanafil for the treatment of erectile dysfunction in men following bilateral, nerve-sparing radical prostatectomy.  In this study, radical prostatectomy patients treated with avanafil had significant improvement in erectile function as compared to the placebo-treated group.

About AvanafilAvanafil is an investigational oral drug being developed for the treatment of erectile dysfunction.  Avanafil is a highly selective phosphodiesterase type 5 (PDE5) inhibitor licensed from Mitsubishi Tanabe Pharma Corporation. VIVUS owns worldwide development and commercial rights to avanafil for the treatment of sexual dysfunction, with the exception of certain Asian Pacific Rim countries.

About VIVUS VIVUS is a biopharmaceutical company developing therapies to address obesity, sleep apnea, diabetes and male sexual health.  The company's lead investigational product in clinical development, Qnexa, has completed phase 3 clinical trials for the treatment of obesity and is currently being considered for approval by US and EU regulators.  VIVUS received a Complete Response Letter, or CRL, to the initial Qnexa NDA on October 28, 2010.  We resubmitted the Qnexa NDA in October 2011, with an FDA action date of April 17, 2012.  Qnexa is also in phase 2 clinical development for the treatment of type 2 diabetes an
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5. VIVUS to Host Conference Call and Webcast Discussion of Avanafil Phase 3 Results
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