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Auxilium Pharmaceuticals Announces Additional Data from Three-Year XIAFLEX® Recurrence Study in Dupuytren's Contracture in E-poster at ASSH Meeting
Date:9/8/2011

was successfully treated (had previously achieved a reduction in contracture to five degrees or less at the Day 30 evaluation after the last injection of XIAFLEX) that subsequently increased by at least 30 degrees compared with the reference value or, (b) a joint which underwent correction to treat contracture in that joint. By this definition of recurrence, only 22% of patients who had achieved clinical success had experienced recurrence at three years. The recurrence rate for MP joints was 16% and for PIP joints was 39%.

About Surgical Recurrence in Dupuytren's contracture

The surgical literature has variable definitions as to what constitutes recurrence. Depending upon the publication, the type of surgery performed (fasciectomy, fasciotomy, or needle aponeurotomy) and the definition of recurrence, surgical recurrence rates of up to 34% have been reported within the first two years following fasciectomy (6) and, at two years, rates range from 2% to 60% or more (7). Three year surgical recurrence rates can vary from 10% to 65% (2,3,4,8-15), depending upon definition of recurrence. When using a recurrence definition of 30 degrees of worsening, the recurrence rate for fasciectomy was 24% with a mean time to recurrence of 3.7 years (4) and needle aponeurotomy demonstrated a recurrence rate of 65% at 32 months (3,4). When using a recurrence definition of re-operative rate, fasciectomy was 10-15% at approximately 3 years (10,14) and needle aponeurotomy was 19-42% at approximately 3 years (2,3,15,16,17). Higher recurrence rates are seen with surgery in Proximal Interphalangeal (PIP) joints vs. Metacarpophalangeal (MP) joints (7) and with needle aponeurotomy vs. fasciectomy (2,3). Generally, the higher the initial stage of contracture before surgery, the more severe the recurrences (18). The earliest reports of recurrence for fasciectomy were seen in 22% of female and 19% of male Dupuytren's contracture patients at a mean of 12 months followi
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SOURCE Auxilium Pharmaceuticals, Inc.
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4. Auxilium Pharmaceuticals Announces Investor Event to Occur at 2011 ASSH Meeting on September 9, 2011
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7. Auxilium Pharmaceuticals to Announce Second Quarter 2011 Results and Conduct Conference Call on Monday, August 1, 2011
8. Auxilium Pharmaceuticals Announces Results from Three Year CORDLESS Extension Study in Dupuytrens Contracture
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