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Auxilium Pharmaceuticals Announces Additional Data from Three-Year XIAFLEX® Recurrence Study in Dupuytren's Contracture in E-poster at ASSH Meeting
Date:9/8/2011

MALVERN, Pa., Sept. 8, 2011 /PRNewswire/ -- Auxilium Pharmaceuticals, Inc. (NASDAQ: AUXL), a specialty biopharmaceutical company, today announced additional three year recurrence data from the Collagenase Optimal Reduction of Dupuytren's - Long-term Evaluation of Success Study (CORDLESS) for XIAFLEX® (collagenase clostridium histolyticum) in the treatment of adult Dupuytren's contracture patients with a palpable cord. The information is available via e-poster at the American Society for Surgery of the Hand meeting in Las Vegas. In patients who achieved clinical success following XIAFLEX treatment and did not meet the criteria for recurrence through three years, the mean degree of contracture of successfully treated joints remained at approximately the same levels as seen at correction (~0 to 5 degrees). In patients who achieved clinical success following XIAFLEX treatment and had recurrence at three years, the mean degree of contracture of the recurrent joints had yet to return to pre-treatment levels.

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"These data demonstrate the maintenance of success for the 71% of patients who did not recur over three years and a slow return to baseline degree of contracture in recurrent patients following XIAFLEX treatment," said Dr. Philip Blazar, Assistant Professor of Orthopaedic Surgery, Harvard Medical School. "I believe treatment of Dupuytren's patients with XIAFLEX can provide durable outcomes with a low rate of recurrence in the majority of patients."

The CORDLESS study is one of the largest prospective long-term follow-up studies of Dupuytren's contracture patients following an intervention. At three years, 451 patients with metacarpophalangeal (MP) joints that achieved clinical success (less than or equal to 5 degrees) w
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SOURCE Auxilium Pharmaceuticals, Inc.
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