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Auxilium Pharmaceuticals, Inc. Announces First Patient Dosed in Phase 2a Cellulite Study of Collegenase Clostridium Histolyticum
Date:10/23/2013

, the subcutaneous fat cells swell and push upwards.
As a result, the skin between the septae is pushed up and the perpendicular septae thicken, contract and act as an anchor to pull the epidermis downwards and form the classic cellulite dimple. The surrounding adipose tissue forms small bulges under the epidermis around the dimple that can give skin a "cottage cheese" appearance.[iii]

About XIAFLEX (collagenase clostridium histolyticum or CCH) XIAFLEX (collagenase clostridium histolyticum or CCH) is made up of two enzymes (AUX I and AUX 2) that are thought to work together to break down collagen.  XIAFLEX is approved in the U.S., EU,  Canada, and Australia for the treatment of adult Dupuytren's contracture (DC) patients with a palpable cord.  A sBLA for XIAFLEX for the treatment of Peyronie's disease (PD) has been submitted to the FDA.  Additionally CCH is currently being studied in clinical trials in the following collagen-related conditions, frozen shoulder syndrome (Phase 2), cellulite (Phase 2), and lipoma (Phase 2).  XIAFLEX has been granted orphan status in the U.S. by the FDA for DC and PD.

About AuxiliumAuxilium Pharmaceuticals, Inc. is a specialty biopharmaceutical company with a focus on developing and marketing products to predominantly specialist audiences.  Auxilium markets Testim® (testosterone gel) for the topical treatment of hypogonadism in the U.S. and XIAFLEX (collagenase clostridium histolyticum or CCH) for the treatment of adult Dupuytren's contracture patients with a palpable cord in the U.S. Ferring International Center S.A. markets Testim in certain countries of the EU and Paladin Labs Inc. markets Testim in Canada.  Swedish Orphan Biovitrium AB has marketing rights for XIAPEX® (the EU tradename for collagenase clostridium histolyticum) in 71 Eurasian and African countries.  Asahi Kasei Pharma Corporation has development and commercial rights for XIA
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SOURCE Auxilium Pharmaceuticals, Inc.
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