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Auspex Pharmaceuticals Receives U.S. Patent on Novel JAK Inhibitor SD-900
Date:11/15/2012

ydrogen does not change the shape of a molecule or its electronic structure, it does not change the binding properties of a drug. However, in certain cases these substitutions can have a beneficial effect on increasing the half-life of the drug. Because of these properties of deuterium, Auspex believes that SD-900 will have equivalent efficacy to tofacitinib but with the prospect of improved pharmaceutical properties.

About Auspex Pharmaceuticals

Auspex Pharmaceuticals is a privately held biopharmaceutical company located in La Jolla, California.  The company is a pioneer in the use of deuterium in medicinal chemistry, and its most advanced program is focused on the treatment of hyperkinetic movement disorders including Huntington's disease, Tourette syndrome and tardive dyskinesia.  Its lead compound, SD-809, is a novel inhibitor of the vesicular monoamine transporter 2 (VMAT-2). This drug offers the potential for significant advantages over existing therapies including improved safety, reduced drug-drug interactions, and less frequent dosing. SD-809 is expected to enter phase 3 clinical testing in 2013. Auspex is also exploiting its deuterium chemistry approach to optimize drugs in several additional therapeutic areas. Included in the Auspex portfolio are SD-900, a JAK kinase inhibitor for the treatment of autoimmune diseases, SD-560 for the treatment of fibrotic diseases, as well as other compounds. For more information on Auspex, please visit the company's web site at http://www.auspexpharma.com.


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