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Auspex Initiates Phase 3 Trial of SD-809 in Huntington's Disease
Date:7/11/2013

University School of Medicine, and Dr. Claudia Testa at Virginia Commonwealth University. Individuals with a diagnosis of HD who are interested in participating in First-HD may visit the HSG website: www.huntington-study-group.org or call toll free: 1(800) 487-7671 (North America). More information about this trial can also be found at http://clinicaltrials.gov/ct2/show/NCT01795859.

About the SD-809 Development Program

SD-809 is a novel investigational drug in Phase 3 pivotal trials for the treatment of chorea associated with Huntington's disease. SD-809 inhibits vesicular monoamine transporter Type 2 (VMAT-2), decreasing the amount of dopamine available to work at nerve terminals, and thereby reducing involuntary movements. In early clinical studies, SD-809 has shown an improved pharmacokinetic (PK) profile compared to tetrabenazine, the only FDA-approved treatment. This improved PK results in more consistent blood levels of drug and may enable once or twice daily dosing of SD-809 compared with tetrabenazine, which is usually given three times per day. 

About Huntington's Disease

Huntington's disease is an inherited, progressive, neurodegenerative disease that affects over 30,000 people in the United States.  HD is characterized by brain cell death that usually begins between the ages of 30 to 50. This cell loss results in motor, cognitive and behavioral signs and symptoms including progressive deterioration of cognitive processes and memory (dementia), and behavioral disturbances. Chorea, which is characterized by involuntary movements, is a hallmark of the disease. There is currently only one FDA-approved treatment for chorea associated with Huntington's disease, which is t
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