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Atrium Announces the Publication of the COBEST Trial by the Journal of Vascular Surgery
Date:9/29/2011

HUDSON, N.H., Sept. 29, 2011 /PRNewswire/ -- Atrium Medical Corporation today announced the publication of the COBEST Trial by the Journal of Vascular Surgery.  COBEST (Covered Versus Balloon Expandable Stent Trial) was an independent, landmark, prospective, multi center, randomized, controlled clinical trial that has demonstrated that Atrium's proprietary balloon expandable covered stent technology is superior to traditional bare metal stents for the treatment of aorto-iliac disease.  The journal article, "A comparison of covered vs bare metal stents for the treatment of aorto-iliac occlusive disease" is currently in press and is also available on-line at the publisher's websites, www.elsevier.com or www.sciencedirect.com .

COBEST was the first prospective head-to-head comparison of Atrium's Vascular V12 balloon expandable covered stent versus bare metal stents (BMS) for the treatment of a specific type of Peripheral Arterial Disease (PAD) known as aorto-iliac occlusive disease.  The study's principal investigator, Professor Patrice Mwipatayi, M.D., is head of vascular surgery at Royal Perth Hospital in Perth, Australia.

COBEST has demonstrated that in TASC B, C, and D iliac lesions, patients implanted with Atrium's Advanta V12 were more likely to remain free from binary restenosis and had fewer reinterventions than patients with bare metal stents implanted.  Upon sub-analysis, Dr. Mwipatayi and the other co-investigators have concluded that Atrium's Vascular V12 demonstrated the greatest benefit in patients with more complex disease (TASC C & D lesions).  There were significantly lower restenosis rates, significantly lower target vessel revascularization (TVR) rates, significantly improved ABI's, and, when these more difficult TASC C & D lesions were analyzed, lower occlusion rates were observed at twelve and eighteen
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SOURCE Atrium Medical Corporation
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