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AstraZeneca and Leading Academic Scientists to Collaborate on Alzheimer's Disease Research
Date:7/12/2012

LONDON, July 12, 2012 /PRNewswire/ -- AstraZeneca and Dr. Steven Paul of Weill Cornell Medical College today announced a first of its kind research alliance that brings four leading academic research laboratories together with AstraZeneca to study a major risk factor for Alzheimer's disease, the apolipoprotein E4 genotype (ApoE). Members of the newly established collaboration with AstraZeneca, called the A5 alliance, include Dr. Paul of the Helen and Robert Appel Alzheimer's Disease Research Institute at Weill Cornell, Dr. David Holtzman of Washington University in St Louis, Dr. Peter Davies of The Feinstein Institute for Medical Research and Dr. Cheryl Wellington of the University of British Columbia.

ApoE is considered second only to age as a risk factor for the development of Alzheimer's disease. However, drug discovery efforts involving ApoE have been hampered by challenging biology and a lack of in-vivo models. The A5 alliance members represent a team of academic scientists with expertise in ApoE biology who will focus on identification, validation, and risk reduction of drug targets for treatment of Alzheimer's disease.

Dr. Steve Paul, principal academic collaborator for the A5 alliance and director of the Helen and Robert Appel Alzheimer's Disease Research Institute and professor of neuroscience, psychiatry and pharmacology at Weill Cornell, said: "The formation of the A5 alliance represents a unique academic-industry partnership whereby these Alzheimer's disease experts will link their labs together and work closely with a pharmaceutical company to unlock the science behind ApoE in order to discover new disease-modifying drug targets. We are convinced that ApoE represents a major piece of the Alzheimer's disease puzzle and that each member of the A5 alliance brings a critical piece of that puzzle to the table."

Dr. Menelas Pangalos, executive vice president of Innovative Medicines, AstraZeneca, said: "In February, AstraZeneca initia
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