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AstraZeneca Submits sNDA for NEXIUM(R) I.V. for Peptic Ulcer Bleed Indication

ry, oncology and infectious disease medicines. In the United States, AstraZeneca is a $13.35 billion healthcare business with 12,200 employees committed to improving people's lives. AstraZeneca is listed in the Dow Jones Sustainability Index (Global) as well as the FTSE4Good Index.
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(1) Data on File. AstraZeneca Pharmaceuticals LP. 263698.

(2) J. J.Y. Sung et al. Intravenous esomeprazole for prevention of peptic

ulcer re-bleeding: rationale/design of the Peptic Ulcer Bleed study.

Aliment Pharmacol Ther 2008; 27:666-677.

(3) NEXIUM I.V. Prescribing Information. Indications and usage section.

(4) Lassen et al. Complicated and uncomplicated peptic ulcers in a Danish

county 1993-2002: a population-based cohort study. Am J Gastroenterol


(5) Kang JY et al. Recent trends in hospital admissions and mortality

rates for peptic ulcer in Scotland 1982-2002. Aliment Pharmacol Ther


(6) Soplepmann et al. Peptic ulcer haemorrhage in Tartu County, Estonia:

epidemiology and mortality risk factors. Scand J Gastroenterol


(7) Thomsen et al. Diabetes and 30-day mortality from peptic ulcer

bleeding and perforation: a Danish population-based cohort study.

Diabetes Care 2006;29(4):805-10.

(8) van Leerdam ME et al Acute upper GI bleeding: Did anything change?

Time trend analysis of incidence and outcome of acute upper GI

bleeding between 1993/1994 and 2000. American Journal of

Gastroenterology 2003;98(7):1494-1499. Table 5.

(9) Mose et al. Thirty-day mortality after peptic ulcer bleeding in

hospitalized patients receiving low-dose aspirin at time of

admission. Am J Ge

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