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AstraZeneca Submits sNDA for NEXIUM(R) I.V. for Peptic Ulcer Bleed Indication
Date:5/30/2008

ry, oncology and infectious disease medicines. In the United States, AstraZeneca is a $13.35 billion healthcare business with 12,200 employees committed to improving people's lives. AstraZeneca is listed in the Dow Jones Sustainability Index (Global) as well as the FTSE4Good Index.
For more information visit http://www.astrazeneca-us.com.

References

(1) Data on File. AstraZeneca Pharmaceuticals LP. 263698.

(2) J. J.Y. Sung et al. Intravenous esomeprazole for prevention of peptic

ulcer re-bleeding: rationale/design of the Peptic Ulcer Bleed study.

Aliment Pharmacol Ther 2008; 27:666-677.

(3) NEXIUM I.V. Prescribing Information. Indications and usage section.

(4) Lassen et al. Complicated and uncomplicated peptic ulcers in a Danish

county 1993-2002: a population-based cohort study. Am J Gastroenterol

2006;101(5):945-53.

(5) Kang JY et al. Recent trends in hospital admissions and mortality

rates for peptic ulcer in Scotland 1982-2002. Aliment Pharmacol Ther

2006;24(1):65-79.

(6) Soplepmann et al. Peptic ulcer haemorrhage in Tartu County, Estonia:

epidemiology and mortality risk factors. Scand J Gastroenterol

1997;32(12):1195-200.

(7) Thomsen et al. Diabetes and 30-day mortality from peptic ulcer

bleeding and perforation: a Danish population-based cohort study.

Diabetes Care 2006;29(4):805-10.

(8) van Leerdam ME et al Acute upper GI bleeding: Did anything change?

Time trend analysis of incidence and outcome of acute upper GI

bleeding between 1993/1994 and 2000. American Journal of

Gastroenterology 2003;98(7):1494-1499. Table 5.

(9) Mose et al. Thirty-day mortality after peptic ulcer bleeding in

hospitalized patients receiving low-dose aspirin at time of

admission. Am J Ge
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