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AstraZeneca Initiates Phase III Clinical Programme Evaluating NKTR-118 for Treatment of Opioid-Induced Constipation
Date:3/15/2011

lifornia, with additional R&D operations in Huntsville, Alabama and Hyderabad, India. Further information about Nektar and its drug development programmes and capabilities may be found online at www.nektar.comMedia Enquiries:Neil McCrae

+44 20 7604 8236 (24 hours)Sarah Lindgreen

+44 20 7604 8033 (24 hours)Abigail Baron

+44 20 7604 8034 (24 hours)Investor Enquiries UK:Jonathan Hunt

+44 20 7604 8122 mob: +44 7775 704032Karl Hard

+44 20 7604 8123 mob: +44 7789 654364Nicklas Westerholm

+44 20 7604 8124  mob: +44 7585 404950 Investor Enquiries US:Ed Seage

+1 302 886 4065   mob: +1 302 373 1361Jorgen Winroth

+1 212 579 0506   mob: +1 917 612 4043REFERENCES(6) Thomas, J. Opioid-Induced Bowel Dysfunction. Journal of Pain and Symptom Management. 2008;35(1):103-113.

(7) Bell, T et al. OBD symptoms impair quality of life and daily activities, regardless of frequency and duration of opioid treatment: results of a U.S. patient survey (PROBE survey). Poster presented at The 25th Annual Scientific Meeting of the American Pain Society. San Antonia, TX, USA.

(8) Pappagallo, M. Incidence, prevalence, and management of opioid bowel dysfunction. Am J Surg. 2001:182;S11-S18.

(9) Fakata, K. Peripheral Opioid Antagonists: A Therapeutic Advance for Optimizing Opioid Gastrointestinal Tolerability. The Journal of Family Practice. 2007;56:S1-S12.


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