Navigation Links
AstraZeneca Announces Top-Line Results of OSKIRA-4 Phase IIb Study of Fostamatinib as a Monotherapy for Rheumatoid Arthritis
Date:12/13/2012

rtin Mackay, President of AstraZeneca Research and Development said: "This Phase IIb dose finding study was designed to evaluate the effect of fostamatinib independent of methotrexate and to inform the further development of fostamatinib as a monotherapy treatment for RA.  A more comprehensive assessment of the benefit/risk profile of fostamatinib used in combination with a DMARD is being undertaken in the pivotal studies that form the OSKIRA Phase III programme which are on track to report in the first half of 2013, and would form the basis of regulatory submissions."

Regulatory filings in the US and EU for use in combination with a DMARD based on the OSKIRA Phase III programme, are expected in the second half of 2013.

A more detailed analysis of the OSKIRA-4 findings will be published in due course.

About the OSKIRA programme
Ongoing Phase III trials in the OSKIRA (Oral Syk Inhibition in Rheumatoid Arthritis) programme, include three pivotal studies assessing the efficacy and safety of fostamatinib; two 12-month studies examining the effect of fostamatinib on patients responding inadequately to DMARDs including methotrexate (OSKIRA-1, OSKIRA-2); a six-month study assessing the effect of fostamatinib on patients who have previously responded inadequately to an anti-TNF therapy (OSKIRA-3); and a long-term extension study looking at the ongoing safety and tolerability of fostamatinib (OSKIRA-X).  The three pivotal studies have as their primary endpoint the proportion of patients with ACR20 compared to placebo (ACR20 = American College of Rheumatology 20% response criteria).  The OSKIRA-1 study also has a co-primary endpoint of change from baseline to week 24 in modified total Sharp score (mTSS), an x-ray endpoint assessing structural progression.

These Phase III studies are expected to be completed in the first half of 2013.

For more information about OSKIRA-4 visit:

SOURCE Rigel Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Zacks Bull and Bear of the Day Highlights: Discover Financial Services, POSCO, AstraZeneca, Bayer and Takeda Pharmaceutical
2. AstraZeneca And Cellworks Collaborate To Find New Treatment For Tuberculosis
3. Genpact and AstraZeneca Win Outsourcing Center and SSON Awards
4. AstraZeneca Acquires Neuroscience Assets From Link Medicine
5. AstraZeneca and Leading Academic Scientists to Collaborate on Alzheimers Disease Research
6. Founded by Enlight Biosciences, KNODE partners with AstraZeneca and Other Partners
7. Regulus Therapeutics Forms Strategic Alliance for Discovery, Development and Commercialization of microRNA Therapeutics with AstraZeneca
8. AstraZeneca And The Broad Institute Partner To Advance Discovery Of Antibacterial And Antiviral Agents
9. Isis Pharmaceuticals And AstraZeneca Form Strategic Alliance On RNA Therapeutics For Cancer
10. Precision Optics Corporation Announces $1 Million Order for Microprecision™ Based Endoscopes
11. Young Innovations, Inc. Announces Record Sales and EPS for the Quarter Ended March 31, 2012
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/6/2015)... YORK , March 6, 2015  Pomerantz LLP ... Pharmaceuticals Inc. ("Conatus" or the "Company") (NASDAQ: ... Robert S. Willoughby at rswilloughby@pomlaw.com or ... Conatus and certain of its officers and/or directors have ... Act of 1934.  On March 5, ...
(Date:3/6/2015)... --  Hospira, Inc. (NYSE: HSP ), applauds ... today,s FDA approval of the first biosimilar in ... for improving patient access to safe, effective and more affordable ... has seen first-hand the positive impact of biosimilars in other ... stages of the development of a pathway for these medicines ...
(Date:3/6/2015)... Fla. , March 6, 2015 ... special validation from Intuitive Surgical, the manufacturer of ... their Triton-36 Instrument Cleaning System. This approval reflects ... standards in cleanliness currently in place for the ... special validation for reprocessing robotic surgical instruments for ...
Breaking Medicine Technology:SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Conatus Pharmaceuticals Inc. - CNAT 2Hospira Statement on FDA Approval of the First Biosimilar in the United States 2Hospira Statement on FDA Approval of the First Biosimilar in the United States 3Ultra Clean Systems Reaches Exclusive Place within Robotic Surgical Instrument Cleaning Industry with Latest Certifications 2
... /PRNewswire-Asia/ -- Mindray Medical International Limited (NYSE: ... medical devices worldwide, announced today an agreement to acquire ... Ltd. ("Greenlander"). The terms of the agreement were not ... statements. Founded in 2003 and based ...
... Better Health ™, a program of Lilly USA, LLC, (NYSE: ... active lives, has launched an expanded Spanish portal on ... Espanol section features a 60-page interactive health album ... and managing health conditions. Additionally, visitors will find more than ...
Cached Medicine Technology:Mindray Medical to Acquire a Controlling Stake in Zhejiang Greenlander Information Technology 2Mindray Medical to Acquire a Controlling Stake in Zhejiang Greenlander Information Technology 3Lilly for Better Health™ Expands Website to Include Spanish Health Information and Interactive Tools 2Lilly for Better Health™ Expands Website to Include Spanish Health Information and Interactive Tools 3
(Date:3/6/2015)... 06, 2015 First Choice Emergency Room ... new facility is located at 13351 W. Bowles Avenue, Littleton, ... team is ready 24-7 to provide the highest quality emergency ... Medical Director of First Choice Emergency Room Littleton. ... the South Metro Denver Chamber of Commerce and a medical ...
(Date:3/6/2015)... Magellan Rx Management’s 2014 Medical Pharmacy ... key trends and statistics on one of the nation’s ... Magellan Rx Management will discuss key findings from the ... Specialty Drug Spend,” a complimentary March 19 webinar, managed ... drug spend makes up more than a quarter of ...
(Date:3/6/2015)... In a new study conducted at a Warsaw hospital, ... pain was their first mesothelioma symptom. Surviving Mesothelioma has just ... to read it now. , Doctors at the Central ... mesothelioma patients between 2006 and 2012 and found ... that first prompted them to see a doctor. For some, ...
(Date:3/6/2015)... You Wealth Revolution ( http://www.youwealthrevolution.com/info ... ‘energy’ experiment to determine if quick remote meditations ... quick ‘5 -7 minute’ remote energy and consciousness ... their life improving - often times very quickly. ... According to research, respondents saw the following common ...
(Date:3/6/2015)... March 06, 2015 The producers of ... air dates for Spokane, Washington and vicinity. This is a ... shop and dine, and many outdoor activities. It is also ... local economy. Six major hospitals call the city home and ... border. The medically-focused cable TV program will be broadcast on ...
Breaking Medicine News(10 mins):Health News:First Choice Emergency Room Opens New Facility in Littleton, Colorado 2Health News:Atlantic Information Services, Magellan Rx Management Partner on Complimentary Webinar Outlining Key Findings of New Medical Pharmacy Trend Report 2Health News:New Report Reveals Shoulder Pain Could Signal Early Mesothelioma, According to Surviving Mesothelioma 2Health News:250,000+ Person ‘Remote Energy’ Event has 94.2% of Respondents saying “Life Got Better” 2Health News:The Health Briefs TV Show to Air in Spokane, Washington 2
... ... Public Relations ( http://www.5wpr.com ) , one of the 25 largest PR firms ... Stein ( http://www.philipstein.com/ ) watches to its versatile roster of fashion and ... be a leader in watches and other lifestyle products using proprietary natural frequency ...
... Researchers from the Boston University School of Medicine ... which is over activated in late-stage cancers, is ... patterns of regulatory DNA hypermethylation causing silencing of ... findings, which appear online in Cancer Research ...
... infections, genetics and the environment are complex and mysterious. ... to autoimmune diseases like rheumatoid arthritis and lupus? How ... disease? Our immediate environment interacts with our genetic ... an autoimmune disease, says rheumatologist Prof. Michael Ehrenfeld of ...
... ... with its parent company Logan Consulting, a Chicago IL based consulting and technology firm, effective ... ... Certified partner, today announced it will merge with its parent company Logan Consulting, a Chicago ...
... calories per meal for their children, study found ... information is available on fast-food restaurant menus, parents are ... new research finds. , Often spurred on by legislation, ... about their menu items. But whether this information would ...
... A new, in-home ... disease was presented by lead researcher Dr. Alberto Espay at the American Acadamy of Neurology ... (PRWEB) January ... of gait in people with Parkinson,s disease (PD). , , , , ,It is well ...
Cached Medicine News:Health News:5W Public Relations Adds Philip Stein Watches to Its Fashion & Lifestyle Client Roster 2Health News:5W Public Relations Adds Philip Stein Watches to Its Fashion & Lifestyle Client Roster 3Health News:Discovery of epigenetic memory during breast cancer 2Health News:How arthritis thrives 2Health News:Cornerstone Solutions Merges with Logan Consulting 2Health News:Cornerstone Solutions Merges with Logan Consulting 3Health News:Listing Calories on Fast-Food Menus Cuts Kids' Intake 2Health News:Listing Calories on Fast-Food Menus Cuts Kids' Intake 3Health News:New Treatment for Parkinson's Disease Gait Presented at the American Acadamy of Neurology Annual Meeting 2Health News:New Treatment for Parkinson's Disease Gait Presented at the American Acadamy of Neurology Annual Meeting 3
... The CA-1000 counts a Petri dish in ... the optical characteristics of the colonies as ... CA-1000 is equipped with three types of ... lighter or darker than the agar and ...
Basic critical care testing. Measures pH, pCO2, and pO2 from 85 L whole-blood sample....
... sophisticated whole blood analysis system that is ... satisfying the stringent requirements of the central ... all of the components of a traditional ... sampling unit, all of the sensors and ...
The AVL Omni modular system is a complete blood gas solution designed for high-volume critical care use, with customized test combinations, minimum intervention and flexibility....
Medicine Products: