Navigation Links
AstraZeneca Announces Top-Line Results From OSKIRA-1 Phase 3 Study of Fostamatinib in Rheumatoid Arthritis
Date:4/4/2013

nd, over a 24-week period, evaluated the effectiveness of two dosing regimens of fostamatinib (100 mg twice daily or fostamatinib 100 mg twice daily for four weeks followed by 150 mg once daily) in combination with MTX versus placebo in combination with MTX. Patients on fostamatinib remained on treatment in OSKIRA-1 for 12 months. 

The OSKIRA-2 and OSKIRA-3 results are expected later in the second quarter of 2013.

About ACR20 and mTSSThe American College of Rheumatology (ACR) score represents a percentage improvement in symptoms (tenderness and swelling in the joints). 28 joints are evaluated for tenderness and swelling respectively (prior to taking any required analgesic that day if possible). To qualify for an ACR20 score, a person with RA must have at least 20% fewer tender joints and at least 20% fewer swollen joints. He or she must also show a 20% improvement in at least three of the following five areas: 1) the person's overall (global) assessment of his or her own RA, 2) the physician's global assessment of the person's RA, 3) the person's assessment of his or her own pain, 4) the person's assessment of his or her own physical functioning, and 5) the results of an erythrocyte sedimentation rate or C-reactive protein blood test (both of which test for inflammation).

Radiographic mTSS is measured in the hands and feet using X-rays. mTSS is a measure of bone erosion and joint space narrowing on X-rays. In each hand, 16 areas are measured for erosions and 15 areas are measured for joint space narrowing. In each foot, six areas are measured for erosions and six areas are measured for joint space narrowing.  A smaller change in mTSS over a given time period, given in percentage change of mTSS score, reflects less progression of joint damage.

About the OSKIRA programThe ongoing (Oral SYK Inhibition in Rheumatoid Arthritis) OSKIRA program, has been designed to investigate fostamatinib as a potential new oral treatment option for
'/>"/>

SOURCE Rigel Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Zacks Bull and Bear of the Day Highlights: Discover Financial Services, POSCO, AstraZeneca, Bayer and Takeda Pharmaceutical
2. AstraZeneca And Cellworks Collaborate To Find New Treatment For Tuberculosis
3. Genpact and AstraZeneca Win Outsourcing Center and SSON Awards
4. AstraZeneca Acquires Neuroscience Assets From Link Medicine
5. AstraZeneca and Leading Academic Scientists to Collaborate on Alzheimers Disease Research
6. Founded by Enlight Biosciences, KNODE partners with AstraZeneca and Other Partners
7. Regulus Therapeutics Forms Strategic Alliance for Discovery, Development and Commercialization of microRNA Therapeutics with AstraZeneca
8. AstraZeneca And The Broad Institute Partner To Advance Discovery Of Antibacterial And Antiviral Agents
9. Isis Pharmaceuticals And AstraZeneca Form Strategic Alliance On RNA Therapeutics For Cancer
10. AstraZeneca Announces Top-Line Results of OSKIRA-4 Phase IIb Study of Fostamatinib as a Monotherapy for Rheumatoid Arthritis
11. AstraZeneca Announces Results From Long-Term Safety Trial Of Naloxegol In Patients With Opioid-Induced Constipation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... CHAPEL HILL, N.C. , Dec. 19, 2014 ... marketplace, innovative consumer research and marketing communication tools ... rich and globally competitive – consequently consumers, desires, ... In this environment, market research groups across ... research and marketing communication tools. However, the adoption ...
(Date:12/19/2014)... CARDIFF-BY-THE-SEA, Calif. , Dec. 19, 2014 /PRNewswire/ ...  Sorrento), an oncology company developing new treatments for ... privately-held immuno-oncology company developing proprietary Neukoplast ® ... announced today that the companies have entered into ... CAR-TNK™ (pronounced as "Car-Tank") immunotherapies for the treatment ...
(Date:12/19/2014)... 2014 Somewhere between dropping five pounds and ... But Audicus , a next-generation hearing aids company, ... year. Hearing loss is the third most ... it is often unaddressed. Forty-eight million Americans have hearing ... aid, mainly due to price. Hearing aids traditionally cost ...
Breaking Medicine Technology:Study Uncovers New Tools and Techniques for Understanding Consumer Decision Making 2Sorrento and Conkwest Announce Exclusive Global Collaboration 2Sorrento and Conkwest Announce Exclusive Global Collaboration 3Sorrento and Conkwest Announce Exclusive Global Collaboration 4Sorrento and Conkwest Announce Exclusive Global Collaboration 5Audicus Will Help People Resolve to Hear Better in 2015 2
... MOUNTAIN VIEW, Calif. , April 27 ... for digital cameras, today announced it will add hundreds of thousands ... expansion of its international hotspots. By the end of May, Eye-Fi ... to upload photos and videos directly from their camera to their ...
... April 27 California Natural Products, ... organic and natural foods and beverages for contract ... all-natural sustained energy protein drink called CalNaturale™ Svelte™, ... the company,s 30-year history. Dedicated to providing great ...
Cached Medicine Technology:Eye-Fi Expands Hotspot Access Service Worldwide 2Eye-Fi Expands Hotspot Access Service Worldwide 3Eye-Fi Expands Hotspot Access Service Worldwide 4California Natural Products Unveils CalNaturale(TM) Svelte(TM) All-Natural Sustained Energy Protein Drink 2California Natural Products Unveils CalNaturale(TM) Svelte(TM) All-Natural Sustained Energy Protein Drink 3
(Date:12/22/2014)... 2014 Super Saturday, the last Saturday ... as the busiest day in the 2014 holiday shopping ... Station had a steady pre-Christmas stream of customers, ready ... Saturday. , “I definitely intend to take advantage…of the ... resident who was enjoying The Grass Station’s holiday sale ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 In recognition ... November sales to Hero Reward, a local organization that ... charge. , Located on a couple hundred ... Reward Program offers lodging, world class fishing, hunting, hiking, ... program was founded several years ago to support U.S. ...
(Date:12/22/2014)... Texas (PRWEB) December 22, 2014 7,178 ... and bustle of Black Friday shopping and opted instead ... and marketing education company, for their 5th annual “Black ... charged just $7 to attend the 5 hour ... that they promptly donated to support two Central Texas ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 NAPW ... 2014 Professional Woman of the Year. Ms. Foley is ... As the largest, most-recognized networking organization of professional women ... the National Association of Professional Women is a powerfully ... 300 Local Chapters. , “As a nurse, I felt ...
(Date:12/22/2014)... December 22, 2014 At the ... next month in San Antonio, esteemed experts ... dynamics that often stand in the way of ... , This premier faculty development opportunity is ... Leadership, whose mission is to assist nurse educators ...
Breaking Medicine News(10 mins):Health News:Customers at Colorado’s Grass Station Say They’re Enjoying the Experience of Legally Purchasing Marijuana this Year to Give as Christmas Presents to Friends and Family 2Health News:Discount Labels Donates Portion of November Sales to Hero Reward Program 2Health News:Austin Company Digital Marketer Raises 100K to Fight Childhood Cancer 2Health News:Austin Company Digital Marketer Raises 100K to Fight Childhood Cancer 3Health News:National Association of Professional Women Announces Michelle M. Foley, Vice President of Operations of OTTR Chronic Care Solutions, a 2014 Professional Woman of the Year 2Health News:2015 NLN Leadership Conference February 5-7 San Antonio 2Health News:2015 NLN Leadership Conference February 5-7 San Antonio 3
... Source Database Includes Research From Around the World, ... An information service,containing thousands of scientific articles by ... 400,000 resources, announced the,Johns Hopkins Bloomberg School of ... makes the service one of the largest of ...
... BUT ACTIVE -- VASCULAR BENEFITS FROM EXERCISE , ... their inactive counterparts in a first-of-its kind study from ... in overweight men. , Vascular function is important ... The active cohort saw an average 24 percent improvement ...
... Vertebroplasty shows benefit in study of those with ... -- In osteoporosis patients with spinal fractures, vertebroplasty ... according to a new study. , Vertebroplasty ... fractured vertebra to shore up the fracture and ...
... diabetes/endocrine, infectious disease, musculoskeletal, pediatric, and ... cancer/hemic, mental/nervous system and general ... the leading search,engine for medical professionals, today unveiled ... search the Web for credible,clinical information within general ...
... monitoring system to ... receive ease-of-use recognition., INDIANAPOLIS, March 18 ... Aviva system,making it the first blood glucose monitoring system to ... strips and the ACCU-CHEK,Compact Plus drum of test strips received ...
... researchers have found that the region of the brain ... the thoughts of other people who are similar to ... considering those who are different politically, socially, or religiously. ... of the National Academy of Sciences, the study was ...
Cached Medicine News:Health News:Resources Top 400,000 in Hopkins International Information Service 2Health News:IU Health & Wellness: Research and insights from Indiana University 2Health News:IU Health & Wellness: Research and insights from Indiana University 3Health News:IU Health & Wellness: Research and insights from Indiana University 4Health News:Pain Relief for Osteoporosis Patients With Fractures 2Health News:SearchMedica Offers Medical Professionals Six New Specialized Clinical Web Searches 2Health News:SearchMedica Offers Medical Professionals Six New Specialized Clinical Web Searches 3Health News:ACCU-CHEK(R) Aviva System Receives Arthritis Foundation's Ease-of-Use Commendation 2Health News:ACCU-CHEK(R) Aviva System Receives Arthritis Foundation's Ease-of-Use Commendation 3Health News:Introspective experiences inform inferences about similar people -- but not dissimilar 2Health News:Introspective experiences inform inferences about similar people -- but not dissimilar 3
... very high frequency digital ultrasound eye arc-scanner. ... microscopic resolution images and precision measurement capabilities ... the human eye. Artemis is a very ... use, the patient leans forward placing their ...
... OTI-Scan 1000 is the most advanced ophthalmic ... system operates with a single Macintosh desktop ... with a streamlined internal probe rotator. Every ... designed. The UltraFast 12 MHz B-probe operates ...
... The AB5500 is a combination A-scan and ... capabilities. The A-scan incorporates a high frequency, ... which enables scan capture immediately upon application ... In cases where the axial length of ...
The ultimate ultrasound system for clinical ophthalmologists....
Medicine Products: