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AstraZeneca Announces Innovative New Partnership With Singapore Institutions to Develop Anti-Cancer Compounds
Date:8/14/2008

Treatment in Asia, p. 11

3) Compounds:

AZD6244 (ARRY-142886)

This development compound is a selective inhibitor of MEK 1/2, which blocks pathways implicated in cancer cell growth. AstraZeneca is leading the way in unlocking the potential of MEK inhibitors in the treatment of cancer. Targeting MEK dependant tumours offers an exciting opportunity to develop a more personalised, targeted approach to the treatment of cancer.

AZD1152

This is a selective cytokinesis inhibitor with specificity for Aurora B kinase. Aurora A and B have been shown to be over-expressed in a broad range of tumours.

4)Hung Huynh et al (2006),Clin Cancer Res;4309, Vol 12 (14) July 15


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