Navigation Links
Astellas and Fujita Health University Discover Neuronal Maturation Deficits in Patients Suffering from Schizophrenia and Bipolar Disorder
Date:7/25/2012

TOKYO, July 25, 2012 /PRNewswire/ -- Astellas Pharma Inc. ("Astellas"; Tokyo:4503; President and CEO: Yoshihiko Hatanaka) and Fujita Health University (Aichi, President: Yoshikazu Kurosawa) announced that Astellas Research Institute of America LLC (ARIA), in collaboration with Dr. Tsuyoshi Miyakawa at Institute for Comprehensive Medical Science, Fujita Health University and Stanley Medical Research Institute (SMRI), has discovered deficits in maturation steps of neurogenesis within the hippocampus of patients with schizophrenia / bipolar disorder. This discovery was reported in a Scientific Journal called Translational Psychiatry on July 10, 2012.

The hippocampus is a brain structure that plays a primary role of learning and memory and also controls emotion and stress responses. Previous studies have found strong links between hippocampal malfunction and psychiatric disorders, including schizophrenia and bipolar disorder. The hippocampus is also known as one of the only two brain regions that have new neurons generated into adulthood (adult neurogenesis). It is believed that the disturbances in the generation of new neurons may affect the function of the hippocampus, resulting in behavioral and cognitive alterations seen in some psychiatric diseases.

Human genetics studies have discovered that genetic variations (mutations) constitute predisposition to schizophrenia and bipolar disorder. Dr. Miyakawa's research group at Fujita Health University reported that a subgroup of gene-manipulated mouse mutants show not only behavioral deficits reminiscent of patients with psychiatric disorders (including cognitive deficits and social withdrawal) but also deficits in maturation of newly-born neurons in the hippocampus. Specifically, mutant mice have more immature neurons (expressing protein marker Calretinin) and less mature neurons (expressing protein marker Calbindin) in their hippocampal dentate gyrus, r
'/>"/>

SOURCE Astellas Pharma Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. First sales of DIFICLIRâ„¢ by Astellas Pharma Europe triggers 10 Million Euro Milestone Payment to Optimer Pharmaceuticals
2. Vibra Healthcare Announces Agreement To Manage Two Acute Rehabilitation Hospitals
3. RxAlly Adds Nationally Recognized Health Care Policy Professional Wayne Oliver To The Companys Leadership Team
4. Sexual Health Care Option For Post-Hysterectomy Patients
5. TMG Health To Present Kip Piper at Thought Leadership Dinner
6. CVS Caremark Charitable Trust Partners with National Association of Community Health Centers to Create Innovative Grant Program Focused on Managing Chronic Disease
7. Hydroxycut Offers Healthy Advice Amidst Weight Loss Controversy
8. eCardio Supports the Carolinas HealthCare Foundation Through Grant for Heart Of A Champion Day
9. TSI Healthcare adds Arthritis and Rheumatology Associates of Palm Beach to growing list of Rheumatology Clients
10. China Health Resource Announces Go Global Initiative For New Product Introductions
11. Cone Health Pioneers Use of Fabric That Heals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/16/2015)... April 16, 2015  Alexza Pharmaceuticals, Inc. (Nasdaq: ALXA ... 31, 2015 on Wednesday, May 6, 2015, following the close ... an investor conference call and live webcast on the same ... update and discuss the financial results.  To ... , under the "Investors" link.  Please log onto the webcast ...
(Date:4/16/2015)... -- Mallinckrodt plc (NYSE: MNK ), a ... has completed its acquisition of Ikaria, Inc. at ... Ikaria acquisition extends Mallinckrodt,s footprint in the hospital ... care with INOMAX ® (inhaled nitric oxide), ... patient population. It also accelerates Mallinckrodt,s rapid growth ...
(Date:4/16/2015)...  Diplomat Pharmacy, Inc. (NYSE: DPLO ) announced ... senior leadership team as chief information security officer. In ... properly monitoring Diplomat,s data, systems and facilities to ensure ... she will play key roles in systems auditing and ... excited to have someone of Shannon,s caliber and experience ...
Breaking Medicine Technology:Alexza to Report 2015 First Quarter Financial Results and Provide Corporate Update on Wednesday, May 6, 2015 2Alexza to Report 2015 First Quarter Financial Results and Provide Corporate Update on Wednesday, May 6, 2015 3Mallinckrodt Completes Acquisition Of Ikaria 2Mallinckrodt Completes Acquisition Of Ikaria 3Mallinckrodt Completes Acquisition Of Ikaria 4Mallinckrodt Completes Acquisition Of Ikaria 5Diplomat Names Shannon M. Beltrand as New CISO 2
... Codifa Enables Italian Professionals to Take Better Decisions ... provider of scientific, technical, and medical information products and services, ... http://www.codifa.it ), an easy to use and powerful online point ... "We are delighted to provide real time access to ...
... 3, 2011 HASCO Medical, Inc. (OTCBB: HASC), ... in Alabama, Florida, and Mississippi, announced the combined audited ... quarter results for HASCO Medical, Mobility Freedom ( www.MobilityFreedom.com ... Combined financial highlights for HASCO ...
Cached Medicine Technology:Elsevier Launches Next Generation Codifa, Providing Italian Doctors with Real Time Access to Critical Drug Information 2HASCO Medical, Inc. and Its Wholly Owned Subsidiary Mobility Freedom Announced Combined Pro Forma Financial Results for Year-End 2010 and First Quarter 2011 2
(Date:4/19/2015)... (PRWEB) April 19, 2015 Carinsurancehints.com has released ... who have to claim auto insurance benefits . ... pictures and gather all the necessary information for claiming auto ... a good insurance plan to cover most of the damages. ... insurance benefits for an accident. , Drivers can compare ...
(Date:4/19/2015)... New court documents issued by the ... Lipitor lawsuits ( http://www.lipitorlawsuitcenter.com/ ) continue to mount in ... of South Carolina. According to the April 15th filing, ... the proceeding on behalf of individuals who allegedly developed ... cholesterol-lowering statin. This represents an increase of 110 filings ...
(Date:4/19/2015)... Indiana Fiber Network, LLC (IFN), ... a major bandwidth upgrade infrastructure service to AdamsWells ... Craigville Telephone Company, Inc. (DBA AdamsWells), one of ... protected 10 Gigabit internet transport ring. , ... Sales and Marketing, AdamsWells expanded Internet bandwidth will ...
(Date:4/18/2015)... The Residential Senior Care Franchises ... years. The industry, which provides residential and personal-care services ... for themselves, has boomed on account of the aging ... seniors with memory impairment. As a result, IBISWorld expects ... 4.1% to $1.9 billion over the five years to ...
(Date:4/18/2015)... April 18, 2015 Carinsurancehints.com has released a ... plans that offer financial protection against fire damage. ... pay benefits in case their vehicle is set intentionally on ... caused by rioting or by other things. , It ... on a single website http://www.carinsurancehints.com/ , in just ...
Breaking Medicine News(10 mins):Health News:An Online Guide About Claiming Auto Insurance Benefits After an Accident 2Health News:Lipitor Lawsuits Mount, as New Court Report Shows More Than 100 Filings Added to Federal Litigation Since March 2Health News:Lipitor Lawsuits Mount, as New Court Report Shows More Than 100 Filings Added to Federal Litigation Since March 3Health News:AdamsWells Internet Telecom TV Expands Bandwidth via Indiana Fiber Network, LLC 2Health News:Residential Senior Care Franchises in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Residential Senior Care Franchises in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:Online Auto Insurance Quotes For Plans That Cover Fire Damages! 2
... ARBOR, Mich.--- A new Bluetooth system designed primarily for blind ... world to tell pedestrians about points of interest along their ... orientation system was developed at the University of Michigan. Researchers ... , "Blind people can get from point A to point ...
... IBD have high risk of infection by hepatitis viruses ... disease, they need blood transfusions, and sometimes surgical and ... to alert health professionals about prevention and early diagnosis ... used in IBD treatment worsen the HBV liver disease. ...
... Bluegrass Bariatric Surgical,Associates announced today that the ... registry designed to evaluate the results of an,innovative ... ROSE (Revision Obesity Surgery, Endolumenal). The ROSE procedure ... pouch and stoma to,approximate the original post-gastric bypass ...
... a "Viable Alternative" to Standard Injections - 69% ... of Their Diabetes, AUSTIN, Texas, Sept. 17 ... small, disposable injection port about the size of ... 1 and type 2,diabetes, participants, differences in glycosylated ...
... Amazon.com Should Voters Ask Just How Important ... 17 In this presidential,election year, a vice-president ... ever been before. Yet, author and researcher Harry ... where a vice-president nomination seriously,impacted our country and ...
... AMN Healthcare, the largest,healthcare staffing company in ... International (OGPI), today announced AMN,s,endorsement of a Code ... the United States., A task force, including ... and licensure bodies developed the "Voluntary,Code of Ethical ...
Cached Medicine News:Health News:New Bluetooth system orients blind and sighted pedestrians 2Health News:New Bluetooth system orients blind and sighted pedestrians 3Health News:The prevalence of hepatitis B virus infection in inflammatory bowel disease patients 2Health News:Final Patient Enrolled In Large Data Registry of Incisionless Gastric Pouch and Stoma Reduction Procedure 2Health News:Final Patient Enrolled In Large Data Registry of Incisionless Gastric Pouch and Stoma Reduction Procedure 3Health News:Final Patient Enrolled In Large Data Registry of Incisionless Gastric Pouch and Stoma Reduction Procedure 4Health News:Diabetes Spectrum Reports a Study Assessing the i-port(R) Injection Port for Administration of Insulin 2Health News:Diabetes Spectrum Reports a Study Assessing the i-port(R) Injection Port for Administration of Insulin 3Health News:A Conspiracy of Silence: Impact on History The Health and Death of Franklin D. Roosevelt 2Health News:AMN Healthcare, OGPI Endorse AcademyHealth's Code of Conduct for Recruitment of Foreign-Educated Nurses 2Health News:AMN Healthcare, OGPI Endorse AcademyHealth's Code of Conduct for Recruitment of Foreign-Educated Nurses 3
... VERSASTEP™ Plus Short Instrument ... , ,The VERSASTEP™ Plus ... Working Length is a unique ... applications in laparoscopic procedures. It ...
... consists of a blunt obturator connected to ... , ,The valve body assembly contains ... prevent gas leakage when instruments are inserted ... includes built-in converters to allow insertion of ...
... One-Step™ single-use system device is comprised of ... components for creating each access port are ... , Step™ insufflation and access needle, 14 ... , Step™ radially expandable sleeve, 100 mm ...
... single-use seal system contains an internal seal to ... withdrawn, without loss of pneumoperitoneum. The 5 mm ... ranging from 5 mm - 12 mm as ... of the diameter of the trocar to allow ...
Medicine Products: