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AspenBio Pharma Reports Strong Results with Appendicitis Triage Blood Test from Large Multiple Hospital Study
Date:9/28/2007

This would represent more than a 100,000 unnecessary surgeries annually.

A total of 249 of the 311 (80%) evaluable patients underwent computed tomography (CT) procedures. Of these 249, 162 were patients that were determined to not have appendicitis. AppyScore accurately identified 68 of these 162 patients as negative for appendicitis and therefore could have reduced the need for these CTs by 42%.

Based upon the results of this study (which is believed to have included a higher than expected percentage of patients with appendicitis or other serious medical conditions that were diagnosed) the specificity of the AppyScore screen test on a stand-alone basis was 40% in our study population. Lower specificity is a typical tradeoff in a screen test that has very high sensitivity. AppyScore is a blood test designed to be used as an aid in screening or triage prior to further clinical workup, such as CT scanning, which is the current standard of care. In AspenBio's latest study, the combination of using the data from AppyScore Screen Test in conjunction with a CT scan resulted in a specificity of 99% (95% CI = 97% to 99.9%). So when AppyScore and CT both are positive, there is an extremely high probability the patient truly has appendicitis.

Dr. John Bealer, a Denver based pediatric surgeon, consultant to AspenBio, and co-inventor of the test noted, "Appendicitis patients are very vulnerable in the current diagnostic process. They are vulnerable to the accuracy of the process as well as from the radiation exposure and expense associated with the widespread use of CT scanning. From the beginning of this project, our goal has been to develop a product that will help physicians better diagnose these vulnerable patients. Ultimately, it is our hope that AppyScore will facilitate a timelier and more focused diagnostic process that will improve patient outcomes through the appropriate use of imaging and the avoidance of the serious complications associated with a
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SOURCE AspenBio Pharma, Inc.
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