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Article Published in Expert Opinion on Biological Therapy Evaluates StemEx(R) (carlecortemcel-l) for Leukemia and Lymphoma
Date:9/30/2009

ter) suggested that the infusion of these expanded cells ... may improve transplant outcome in large-sized patients."

StemEx is a graft of an expanded population of stem/progenitor cells, derived from part of a single unit of umbilical cord blood and transplanted by IV along with the remaining unit of non-manipulated cells. It is currently being evaluated in an international, Phase II/III, FDA, pivotal registration study called ExCell, now enrolling adolescents and adults with high-risk hematologic malignancies, at clinical sites in the U.S., Italy, Spain, Hungary and Israel. (http://www.stemexstudy.com ).

The study is being conducted to verify the safety and efficacy of this product by comparing the overall 100-day mortality with that of a historical cohort from international umbilical cord

blood transplant registries. It is also evaluating the feasibility of centralized manufacturing and shipping of expanded cord blood cells to transplant centers for infusion. The speed and completeness of engraftment and the long-term hematologic and immunologic reconstitution of the recipients will shed light on the role of expanded UCB cells in transplantation.

StemEx is being developed by the joint venture of Gamida Cell and Teva Pharmaceutical Industries (NASDAQ: Teva). Market launch is anticipated for 2011.

About Gamida Cell

Gamida Cell Ltd. is a world leader in stem cell expansion technologies and therapeutic products. The company is developing a pipeline of products in stem cell transplantation and in tissue regeneration to effectively treat debilitating and often fatal illnesses such as cancer, hematological, autoimmune and ischemic diseases. Gamida Cell's therapeutic candidates contain populations of adult stem cells, selected from non-controversial sources such as umbilical cord blood and bone marrow, which are expanded in culture. Gam
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SOURCE Gamida Cell LTD
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