Navigation Links
Arrien Pharmaceuticals Founder's closes $2.0 Million Series A Financing

ANSONIA, Conn., Sept. 12, 2011 /PRNewswire/ -- Arrien Pharmaceuticals LLC (Arrien) is a new start-up Company located in the Connecticut & Salt Lake City area announces today of its successful completion of Series A financing from contributions by the founders of the company and currently engaged in the discovery and development of breakthrough novel small molecules targeting cell signalling pathways. Arrien developed a proprietary platform - Fragment-Field Drug Design (FFDD™) Technology with the efforts of experienced Medicinal Chemists and initiated to discover small molecule targeted therapeutics for addressing unmet need in treating Parkinson's, Alzheimer's, Down's syndrome, Huntington's, Multiple Cancer Indications, Rheumatoid Arthritis (RA), Type 2 Diabetes and Obesity diseases.

ORS-1006 is the Company's lead small molecule First-in-Class candidate inhibitor of Protein Kinase for Parkinson Disease (PD). ORS-1006 shows neuroptotective effect in cell culture models of PD, potent activity in Parkinsonian mouse models, kinase selective and has demonstrated an excellent PK profile. Arrien completed early pre-clinical PK/PD studies, IND-enabling toxicology studies for ORS-1006, which included Maximum Tolerated Dose (MTD) studies and repeat-dose toxicity studies in rodents and non-rodents is expected to start by Q4 2011.

In addition, Arrien has identified an active First-in-Class ARN-1032 and ARN-3016 which are potent inhibitors of protein kinases and demonstrated potent anticancer activities in a variety of cancer cell lines. Currently Arrien is conducting lead optimization process and early PK studies.

Mr. Rajendra P. Appalaneni Chairman/CEO, an experienced Chemist/Pharmacist/Pharmacologist, Successful Serial Entrepreneur and The Founder/Chief Executive Officer (CEO) of Arrien Pharmaceuticals commented at the Arrien board meeting on completion of this financing to advance Arrien promising pre-clinical Parkinson's disease lead candidate ORS-1006 into IND enabling studies.

Commenting on the announcement, Dr. Hariprasad Founder/Scientific Advisory Board Member had more than 16 years of experience stated "we are delighted that the Arrien combines with the team of Business Entrepreneurs, Medicinal Chemists with an early discovery & development expertise and Arrien's discovery pipeline could contribute substantially to the future therapeutics."

Arrien Pharmaceuticals is working for a possible licensing & alliance deals for near term funding securities to expand significantly to its value based pipeline. Arrien is seeking collaborations with companies for a number of programs for which it expects to file 2 INDs between Q4 2011-12 related to protein kinase mediated Parkinson's, Cancer and other disease indications.

About Arrien Pharmaceuticals & FFDD™

Arrien Pharmaceuticals LLC is a small molecule targeted therapeutics drug discovery and development company working towards targeting cell signaling pathways - A target class in treating Neurodegenerative/CNS, Cancer, Inflammation and Metabolic diseases. Arrien proprietary Fragment-Field Design (FFD) Technology™ typically involves scaffold-based design strategy; extensively implemented by utilizing structural biology data inputs and to assist Medicinal Chemistry in early phase of lead-to-drug-lead identification process along with its target focused scaffold-like libraries to design new lead candidates within various families of protein kinase drug targets. Arrien cost-competent approach assists its technology to influence target-specific leads for multiple protein targets. Moreover, Arrien technology has proven in the identification of potent and highly selective protein kinase inhibitors.  

For further information on Arrien Pharmaceuticals, please visit the company's website

SOURCE Arrien Pharmaceuticals LLC
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Savient Pharmaceuticals Names Kenneth J. Zuerblis Chief Financial Officer
2. HemaQuest Pharmaceuticals Completes Patient Enrollment in Phase 2 Clinical Study of HQK-1001 in Patients With Sickle Cell Disease
3. Optimer Pharmaceuticals DIFICID Featured in 11 Presentations at 51st ICAAC
4. AcelRx Pharmaceuticals to Present at the Rodman & Renshaw Global Investment Conference
5. Valeant Pharmaceuticals Announces Mailing of Offer and Take-Over Bid Circular to Shareholders of Afexa
6. Rescheduled Webcast: Isis Pharmaceuticals Hosts Dr. John Kastelein to Review Mipomersen Long-term Data Recently Presented at ESC Congress 2011
7. Anthera Pharmaceuticals Announces Notice of Allowance of U.S. Patent Application Covering A-002 Plus Statin Compositions
8. Panmira and FLAP LLCs Spun Out of Amira Pharmaceuticals
9. Oramed Pharmaceuticals to Present at Rodman & Renshaw 13th Annual Global Investment Conference
10. Ampio Pharmaceuticals Executes License and Development Agreement with Daewoong Co. Ltd. to Commercialize Zertane™ in South Korea
11. Auxilium Pharmaceuticals Announces Additional Data from Three-Year XIAFLEX® Recurrence Study in Dupuytrens Contracture in E-poster at ASSH Meeting
Post Your Comments:
(Date:6/23/2016)... , June 23, 2016 Roche (SIX: ... 510(k) clearance for its Elecsys BRAHMS PCT (procalcitonin) assay ... sepsis or septic shock. With this clearance, Roche is ... a fully integrated solution for sepsis risk assessment and ... with bacterial infection and PCT levels in blood can ...
(Date:6/23/2016)... , June 23, 2016 , ... Thursday, July 7, 2016 , , , , LOCATION: , ... , , , , EXPERT PANELISTS:  , , , Frost ... Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh ... The global pharmaceutical industry is witnessing an exceptional era. Several ...
(Date:6/23/2016)... , June 23, 2016 The vast ... an outpatient dialysis facility.  Treatments are usually 3 times ... hours per visit, including travel time, equipment preparation and ... patient, but especially grueling for patients who are elderly ... a skilled nursing and rehabilitation centers for some duration ...
Breaking Medicine Technology:
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution is underway. ... transport experience for the millions of people who require these medical transport services ... industry through the use of technology. Now, SmartEMS has put forth an industry-changing ...
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A Forever Recovery, a ... and World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility is ... to some of the world’s leading providers of cereal and other breakfast foods. Its ...
(Date:6/26/2016)... Charlotte, NC (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind ... able to be personalized through a fitness app. The fitness app plans to fix the ... solutions currently only offer a one size fits all type program , They ...
(Date:6/25/2016)... ... ... Austin residents seeking Mohs surgery services, can now turn to Dr. Jessica ... Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to include Mohs ... Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn Goldstein, ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , the largest ... as the Medical Director of its new Mesquite-Samuell Farm facility. , “We are ... Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency ...
Breaking Medicine News(10 mins):