Navigation Links
Arrien Pharmaceuticals Founder's closes $2.0 Million Series A Financing
Date:9/12/2011

ANSONIA, Conn., Sept. 12, 2011 /PRNewswire/ -- Arrien Pharmaceuticals LLC (Arrien) is a new start-up Company located in the Connecticut & Salt Lake City area announces today of its successful completion of Series A financing from contributions by the founders of the company and currently engaged in the discovery and development of breakthrough novel small molecules targeting cell signalling pathways. Arrien developed a proprietary platform - Fragment-Field Drug Design (FFDD™) Technology with the efforts of experienced Medicinal Chemists and initiated to discover small molecule targeted therapeutics for addressing unmet need in treating Parkinson's, Alzheimer's, Down's syndrome, Huntington's, Multiple Cancer Indications, Rheumatoid Arthritis (RA), Type 2 Diabetes and Obesity diseases.

ORS-1006 is the Company's lead small molecule First-in-Class candidate inhibitor of Protein Kinase for Parkinson Disease (PD). ORS-1006 shows neuroptotective effect in cell culture models of PD, potent activity in Parkinsonian mouse models, kinase selective and has demonstrated an excellent PK profile. Arrien completed early pre-clinical PK/PD studies, IND-enabling toxicology studies for ORS-1006, which included Maximum Tolerated Dose (MTD) studies and repeat-dose toxicity studies in rodents and non-rodents is expected to start by Q4 2011.

In addition, Arrien has identified an active First-in-Class ARN-1032 and ARN-3016 which are potent inhibitors of protein kinases and demonstrated potent anticancer activities in a variety of cancer cell lines. Currently Arrien is conducting lead optimization process and early PK studies.

Mr. Rajendra P. Appalaneni Chairman/CEO, an experienced Chemist/Pharmacist/Pharmacologist, Successful Serial Entrepreneur and The Founder/Chief Executive Officer (CEO) of Arrien Pharmaceuticals commented at the Arrien board meeting on completion of this financing to advance Arrien promising pre-clinical Parkinson's disease lead candidate ORS-1006 into IND enabling studies.

Commenting on the announcement, Dr. Hariprasad Founder/Scientific Advisory Board Member had more than 16 years of experience stated "we are delighted that the Arrien combines with the team of Business Entrepreneurs, Medicinal Chemists with an early discovery & development expertise and Arrien's discovery pipeline could contribute substantially to the future therapeutics."

Arrien Pharmaceuticals is working for a possible licensing & alliance deals for near term funding securities to expand significantly to its value based pipeline. Arrien is seeking collaborations with companies for a number of programs for which it expects to file 2 INDs between Q4 2011-12 related to protein kinase mediated Parkinson's, Cancer and other disease indications.

About Arrien Pharmaceuticals & FFDD™

Arrien Pharmaceuticals LLC is a small molecule targeted therapeutics drug discovery and development company working towards targeting cell signaling pathways - A target class in treating Neurodegenerative/CNS, Cancer, Inflammation and Metabolic diseases. Arrien proprietary Fragment-Field Design (FFD) Technology™ typically involves scaffold-based design strategy; extensively implemented by utilizing structural biology data inputs and to assist Medicinal Chemistry in early phase of lead-to-drug-lead identification process along with its target focused scaffold-like libraries to design new lead candidates within various families of protein kinase drug targets. Arrien cost-competent approach assists its technology to influence target-specific leads for multiple protein targets. Moreover, Arrien technology has proven in the identification of potent and highly selective protein kinase inhibitors.  

For further information on Arrien Pharmaceuticals, please visit the company's website www.arrienpharma.com.


'/>"/>
SOURCE Arrien Pharmaceuticals LLC
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Savient Pharmaceuticals Names Kenneth J. Zuerblis Chief Financial Officer
2. HemaQuest Pharmaceuticals Completes Patient Enrollment in Phase 2 Clinical Study of HQK-1001 in Patients With Sickle Cell Disease
3. Optimer Pharmaceuticals DIFICID Featured in 11 Presentations at 51st ICAAC
4. AcelRx Pharmaceuticals to Present at the Rodman & Renshaw Global Investment Conference
5. Valeant Pharmaceuticals Announces Mailing of Offer and Take-Over Bid Circular to Shareholders of Afexa
6. Rescheduled Webcast: Isis Pharmaceuticals Hosts Dr. John Kastelein to Review Mipomersen Long-term Data Recently Presented at ESC Congress 2011
7. Anthera Pharmaceuticals Announces Notice of Allowance of U.S. Patent Application Covering A-002 Plus Statin Compositions
8. Panmira and FLAP LLCs Spun Out of Amira Pharmaceuticals
9. Oramed Pharmaceuticals to Present at Rodman & Renshaw 13th Annual Global Investment Conference
10. Ampio Pharmaceuticals Executes License and Development Agreement with Daewoong Co. Ltd. to Commercialize Zertane™ in South Korea
11. Auxilium Pharmaceuticals Announces Additional Data from Three-Year XIAFLEX® Recurrence Study in Dupuytrens Contracture in E-poster at ASSH Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2017)... 20, 2017  Cogentix Medical, Inc. (NASDAQ: CGNT), ... the Urology, Uro/Gyn and Gynecology markets with innovative ... has joined the Company as Senior Vice President, ... position, Mr. Keswani will report directly to ... "Our organization is delighted that Ash has joined ...
(Date:4/20/2017)... , April 20, 2017  RXi Pharmaceuticals Corporation ... therapeutics that address significant unmet medical needs, today ... the Company,s consumer product development program, based on ... Society for Investigative Dermatology (SID) 76 th ... and promote the sciences relevant to skin health ...
(Date:4/20/2017)... , April 20, 2017  AbbVie (NYSE: ... 99 percent (n=145/146) of chronic hepatitis C virus ... 5 or 6 and compensated cirrhosis (Child-Pugh A) ... (SVR 12 ) with its investigational, pan-genotypic regimen ... rates were seen following 12 weeks of G/P ...
Breaking Medicine Technology:
(Date:4/29/2017)... ... April 29, 2017 , ... TransDark is a set ... one video to the next without having to set a single keyframe in ... to enhance your video production. , TransDark features dynamic transitions that momentarily splits the ...
(Date:4/28/2017)... (PRWEB) , ... April 28, 2017 , ... An April 24th article on ... stunning 180 pounds with the help of a weight loss surgery. The woman, declaring “I ... skin that have been left following her dramatic weight loss. Dr. Feiz & Associates notes ...
(Date:4/28/2017)... , ... April 28, 2017 , ... Beginning in 2017, ... their formulas. This begins with the popular ClearLungs Extra Strength formula. To ensure that ... the formula in the following ways:, , Removal of the ...
(Date:4/28/2017)... ... April 28, 2017 , ... Ushio America ... lamps offer an instant energy-saving solution for F32T8 fluorescent lamps on most instant-start ... ballasts. These 50,000 hour rated lamps utilize the existing electronic ballast, saving labor ...
(Date:4/28/2017)... ... April 28, 2017 , ... From ... College of Urgent Care Medicine will host industry leaders for the annual spring ... help those in the industry adapt to the issues currently affecting urgent care ...
Breaking Medicine News(10 mins):