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Array BioPharma Reports Financial Results for the Third Quarter of Fiscal 2013
Date:5/6/2013

13 American Society of Clinical Oncology (ASCO) Annual Meeting:Title:Preliminary results from a phase Ib/II, open-label, dose-escalation study of the oral BRAF inhibitor LGX818 in combination with the oral MEK1/2 inhibitor MEK162 in BRAF V600-dependent advanced solid tumors (Abstract #9029 / Poster board #17)Date:Monday, June 3, 8 am – 12-noon CDTIn addition, the data will be discussed during the poster discussion session on Monday, June 3 from 11:30 am – 12:30 pm CDT.Selumetinib – AstraZeneca to initiate two registration trials in 2013 and present data at ASCOAstraZeneca announced at their Analyst Day in March that they expect to initiate two pivotal trials with selumetinib in 2013.  The first will be with selumetinib in combination with docetaxel in KRAS-mutant non-small cell lung cancer based on the strength of the Phase 2 data AstraZeneca presented at ASCO 2012.  The second registration trial will be a pivotal trial with selumetinib in thyroid cancer.  Also during the event, AstraZeneca projected selumetinib peak annual sales to exceed $1 billion and suggested selumetinib may have potential application in high unmet need indications such as uveal melanoma, neurofibromatosis and gastrointestinal cancers.  In addition, AstraZeneca showed the advantages of selumetinib over GlaxoSmithKline's MEK inhibitor, trametinib, when combining with standard chemotherapy. 

The following oral presentations on selumetinib will be made by AstraZeneca at the ASCO annual meeting:Title:Phase II study of selumetinib versus temozolomide in gnaq/Gna11 mutant uveal melanoma (Abstract # CRA9003)Presenter:Richard D. Carvajal, MDDate:Saturday, June 1, 2:15 – 2:30 pm CDTTitle:Phase II double-blind, randomized study of selumetinib plus dacarbazine (DTIC) versus placebo plus DTIC as first-line treatment for advanced BRAF-mutant cutaneous or unknown primary melanoma (Abstract # 9004)  Presenter:Mark R. Middleton, PhD, FRCPDate:Saturd
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