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Array BioPharma Reports Financial Results For The First Quarter Of Fiscal 2014 And Announces ARRY-520 Development Strategy
Date:10/31/2013

e 2 data presented at the 2012 ASCO Annual Meeting.  Array earned a milestone payment for the start of this study in October 2013.

SELECT-1 is a randomized, double-blind, placebo-controlled study that will evaluate the safety and efficacy of selumetinib in combination with docetaxel with PFS as the primary endpoint.  Secondary endpoints include ORR and OS. SELECT-1, which will enroll approximately 630 patients, will be the largest prospective study ever conducted in this patient population, a genetic sub-type of lung cancer associated with poor prognosis and limited treatment options.  KRAS mutations drive approximately 20 percent of human cancers and have been found in 20 to 30 percent of NSCLC tumors.

AstraZeneca is also conducting two additional registration trials.  A pivotal study assessing the efficacy and tolerability of selumetinib combined with radioactive iodine as adjuvant therapy in patients with differentiated thyroid cancer with high risk of recurrence started in August 2013, and a pivotal study assessing the efficacy and tolerability in combination with dacarbazine in patients with metastatic uveal melanoma is planned to start in late 2013.ARRY-380 (ONT-380) (collaboration with Oncothyreon) – Trial initiated in patients with HER2+ breast cancer with brain metastases
ARRY-380 is an orally active, reversible and selective small-molecule HER2 inhibitor. A trial of ARRY-380 in combination with Herceptin® (trastuzumab) was initiated in patients with brain metastases from HER2+ breast cancer.  The trial is being conducted under the sponsorship of the Dana-Farber Cancer Institute, Boston, Massachusetts.  Oncothyreon plans to start additional studies this year.

CONFERENCE CALL INFORMATION
Array will hold a conference call on Thursday, October 31, 2013, at 9:00 a.m. eastern time to discuss these results.  Ron Squarer, Chief Executive Officer, and '/>"/>

SOURCE Array BioPharma
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