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Array BioPharma Announces Updates on ARRY-520 Clinical Data at the 2013 International Myeloma Workshop
Date:4/4/2013

MCL-1 protein for survival.  As predicted from its targeted mechanism, ARRY-520 has exhibited no neuropathy, alopecia or serious gastrointestinal effects at its recommended dose. 

ARRY‑520 is currently advancing in three clinical trials.  Continued positive results in any one of these trials will define a clear path to late stage development:

  • Phase 2 trial in combination with dexamethasone in patients with MM refractory to Revlimid® (lenalidomide), Velcade and dexamethasone therapy. 
  • Dose escalation trial in combination with Velcade® plus dexamethasone in patients with relapsed or refractory MM.
  • Investigator-sponsored dose escalation trial in combination with Kyprolis® in patients with relapsed or refractory MM who are refractory or intolerant to Velcade therapy. 
  • About Array BioPharma
    Array BioPharma Inc. is a biopharmaceutical company focused on the discovery, development and commercialization of targeted small molecule drugs to treat patients afflicted with cancer. Array is evolving into a late-stage development company and currently expects significant progress toward generating data to support our upcoming Phase 3 / pivotal trial decisions.
    Novartis will begin a Phase 3 trial on Array-invented MEK162 in NRAS mutant melanoma currently scheduled to start in the first half of 2013 as well as a trial in BRAF mutant melanoma expected later in the year.  Also, AstraZeneca announced it intends to start registration trials with selumetinib (an Array invented drug) in non-small cell lung cancer and thyroid cancer during the second half of 2013.  Three other Array invented drugs are also approaching Phase 3 decisions by the end of calendar year 2013. These include Array's wholly-owned drugs, ARRY-520 and ARRY-614, and one partnered program, danoprevir (with InterMune/Roche).  In addition, Array has seven other clinical-stage programs which have b
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