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Array BioPharma Announces Updates on ARRY-520 Clinical Data at the 2013 International Myeloma Workshop
Date:4/4/2013

vated AAG. The identification of this marker may enable more precise targeting of patient populations who will benefit from ARRY-520.

ARRY-520 Plus Velcade® (bortezomib) Clinical Trial in Patients with Relapsed or Refractory MM (Protocol # ARRAY-520-111)

  • ARRY-520 plus Velcade® (bortezomib) combination treatment was generally well-tolerated.  Neutropenia was the most common adverse event and non-hematologic grade 3 or 4 toxicity was infrequent.  Neutropenia was well managed by the use of growth factor support.
  • Initial signs of activity, including responses and prolonged stable disease, were observed in this heavily pretreated population, the majority of whom were refractory to prior Velcade treatment.
  • An alternate treatment regimen with the addition of low-dose dexamethasone will be evaluated in the study.
  • "Myeloma patients have been fortunate to have access to multiple versions of proteasome inhibitors and immunomodulatory agents to induce better and longer remissions, but these agents are effective for only so long. In order to continue to make progress in treating this disease, we need new classes of agents that have the ability to treat resistant disease," said Dr. Sagar Lonial , Professor and Vice Chair of Clinical Affairs, Department of Hematology and Medical Oncology, Emory Winship Cancer Institute. "ARRY-520 is a first-in class drug in myeloma with a novel mechanism of action that is well tolerated and importantly shows encouraging clinical activity in heavily pre-treated patients who have limited therapeutic options."

    About ARRY-520 for Multiple Myeloma
    ARRY-520 is a potent, selective KSP inhibitor with a mechanism of action distinct from other drugs used to treat MM.  ARRY-520 acts preferentially on MM cells over terminally differentiated and epithelial cells due to restricted tissue distribution of KSP and the reliance of MM cells on the
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