Navigation Links
Array BioPharma Announces Clinical Data Presentations At The 2013 ASCO Annual Meeting

BOULDER, Colo., May 15, 2013 /PRNewswire/ -- Array BioPharma Inc. (NASDAQ: ARRY) today announced presentations on its MEK inhibitors, MEK162 (licensed to Novartis) and selumetinib (licensed to AstraZeneca) at the 2013 American Society of Clinical Oncology (ASCO) Annual Meeting, which will be held May 31 – June 4, 2013 in Chicago, Illinois.  Both MEK inhibitors are expected to advance into Phase 3 trials in 2013:  Novartis expects to evaluate MEK162 in NRAS- and BRAF-mutant melanoma and Array expects to evaluate MEK162 in low-grade serous ovarian cancer.  In addition, AstraZeneca expects to begin Phase 3 or pivotal registration trials with selumetinib in non-small cell lung cancer and thyroid cancer. 

The following is a summary of the presentations that will be given at ASCO:  ORAL PRESENTATIONSTitle:Phase II study of selumetinib versus temozolomide in gnaq/Gna11 mutant uveal melanoma (Abstract # CRA9003)Final results will be presented at ASCO.Presenter: Richard D. Carvajal, MDDate:Saturday, June 1, 2:15-2:30 p.m. CDT (Oral Presentation)Embargo:ASCO's embargo for this abstract will lift on Saturday, June 1 at 6:30 a.m. CDT.Press Conference ASCO will feature this study in the 2013 ASCO Annual Meeting press program on Saturday, June 1 from 8 – 9 a.m. CDT.Title: 

Phase II double-blind, randomized study of selumetinib plus dacarbazine versus placebo plus DTIC as first-line treatment for advanced BRAF-mutant cutaneous or unknown primary melanoma (Abstract # 9004)Presenter: Mark R. Middleton, PhD, FRCPDate: 

Saturday, June 1, 2:30-2:45 p.m. CDT POSTER PRESENTATIONSTitle: Preliminary results from a Phase Ib/II, open-label, dose-escalation study of the oral BRAF inhibitor LGX818 in combination with the oral MEK1/2 inhibitor MEK162 in BRAF V600-dependent advanced solid tumors* (Abstract #9029)Presenter: Richard Kefford, MB, BS, PhDDate: Monday, June 3, 8 a.m. – 12 p.m. and 11:30 – 12:30 p.m. CDT (Poster Discussion Session)Title: DOC-MEK: A double-blind randomized Phase II trial of docetaxel with or without selumetinib (AZD6244; ARRY-142886) in wt BRAF advanced melanoma (Abstract # 9068)Presenter: Avinash Gupta, MBBS BSc MRCPDate: Saturday, June 1, 8 – 11:45 a.m. CDTTitle: Custom (Molecular Profiling and Targeted Therapy for Advanced Non-Small Cell Lung Cancer, Small Cell Lung Cancer and Thymic Malignancies trial (Abstract # 7513)Presenter: Giuseppe Giaccone, MD, PhDDate: Saturday, June 1, 8 – 11:45 a.m. CDTTitle: Two parallel randomized Phase II studies of selumetinib and erlotinib in advanced non-small cell lung cancer selected by KRAS mutations (Abstract # 8026)Presenter: Corey A. Carter, MDDate: Saturday, June 2, 8 a.m. – 12 p.m. CDTTitle: SWOG S1115: Randomized Phase II clinical trial of selumetinib (AZD6244; ARRY 142886) hydrogen sulfate (NSC-748727) and MK-2206 (NSC-749607) versus mFOLFOX in patients with metastatic pancreatic cancer after prior chemotherapy (Abstract # TPS4145)Presenter: Vincent M. Chung, MDDate: 

Sunday, June 2, 8 – 11:45 a.m. CDTTitle: 

The MEK inhibitor selumetinib, AZD6244, ARRY-142886) plus irinotecan as second-line therapy for KRAS-mutated metastatic colorectal cancer (Abstract #3587)Presenter: 

Howard S. Hochster, MDDate: 

Sunday, June 2, 8 – 11:45 a.m. CDTTitle: Dual MEK/EGFR inhibition for advanced, chemotherapy-refractory pancreatic cancer: A multicenter phase II trial of selumetinib (AZD6244; ARRY-142886) plus erlotinib (Abstract # 4014)Presenter: Andrew H. Ko, MDDate: Monday, June 3, 1:15 – 5:15 p.m. CDTASCO's embargo for the abstract discussing the Phase 2 results of selumetinib versus temozolomide in uveal melanoma (Abstract # CRA9003) will lift on Saturday, June 1 at 6:30 a.m. CDT.  ASCO's embargo for the remaining abstracts in this release will lift on Wednesday, May 15 at 6:00 p.m. EDT.  All abstracts can be accessed through the ASCO website,  After the presentations and posters are public, they will be available as PDFs on Array's website at

*The MEK162 abstract submitted only incorporates data as of early 2013.  Up-to-date clinical data will be included during the presentation at the Annual Meeting.

About Array BioPharma
Array BioPharma Inc. is a biopharmaceutical company focused on the discovery, development and commercialization of targeted small molecule drugs to treat patients afflicted with cancer. Array is evolving into a late-stage development company and currently expects significant progress toward generating data to support our upcoming Phase 3 / pivotal trial decisions.
Novartis expects to begin Phase 3 trials evaluating Array-invented MEK162 in NRAS- and BRAF-mutant melanoma in 2013.  In addition, Array expects to begin a Phase 3 trial evaluating MEK162 in low-grade serous ovarian cancer under the license agreement with Novartis in 2013.  AstraZeneca expects to begin Phase 3 or pivotal registration trials with selumetinib (an Array-invented drug) in non-small cell lung cancer and thyroid cancer during the second half of 2013.  Three other Array-invented drugs are also approaching Phase 3 or pivotal trial decisions which are expected by the end of 2013. These include Array's wholly-owned drugs, ARRY-520 and ARRY-614, and one partnered program, danoprevir (with InterMune/Roche).  For more information on Array, please go to


Tricia Haugeto (303)

SOURCE Array BioPharma Inc.
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Array Announces Global Phase 3 Trial Evaluating MEK162 In Patients With Low-Grade Serous Ovarian Cancer
2. Array BioPharma Reports Financial Results for the Third Quarter of Fiscal 2013
3. New Versa HD System Tops Elektas Comprehensive Array of Cancer Management Solutions at 2nd ESTRO Forum
4. Array BioPharma Announces Updates on ARRY-520 Clinical Data at the 2013 International Myeloma Workshop
5. Array BioPharma Names Michael N. Needle, M.D. As Chief Medical Officer
6. Array BioPharma To Present At The Cowen Annual Health Care Conference
7. Zacks Bull and Bear of the Day Highlights: Fortune Brands Home & Security, Wal-Mart Stores, Regeneron Pharmaceuticals, Bayer and Array Biopharma
8. Array BioPharma To Present At The Leerink Swann Global Healthcare Conference
9. InternetArray Collaborates with Health Sciences Group to Fund Medical Marijuana Social Media/Mobile Apps Development
10. Array BioPharma To Present At The Piper Jaffray Annual Healthcare Conference
11. Array BioPharma Announces Pricing Of Public Offering Of Common Stock
Post Your Comments:
(Date:12/1/2015)... ) has ... Systems/Personal Emergency Response System (PERS) Market by Type, ... report to their offering. --> ... "Medical Alert Systems/Personal Emergency Response System (PERS) ... - Global Forecas" report to their offering. ...
(Date:12/1/2015)... -- --> --> ... (NKI-AVL), among the world,s largest and most prestigious ... Icon™, the company,s latest generation stereotactic radiosurgery system ... --> With the option to use ... Knife Icon offers greatly enhanced flexibility in how ...
(Date:12/1/2015)... Colo. , Dec. 1, 2015 Ampio ... New York Stock Exchange has established January 5, 2016 as ... its stockholders of the shares of Common Stock of ... (1) share of Aytu common stock for every five ... the record date, December 1, 2015. The distribution date will ...
Breaking Medicine Technology:
(Date:12/1/2015)... ... 2015 , ... For many X-rays taken at hospitals, doctors’ ... by the radiologist. The marking utensils are so small, however, they are difficult ... way to alleviate this problem. , He developed the patent-pending MARK N SHOW ...
(Date:12/1/2015)... CA (PRWEB) , ... December 01, 2015 , ... ... Health Center of Excellence (BHCOE) today announced that the organization has awarded Education ... San Francisco, with a Distinguished Award. The award celebrates exceptional special needs providers ...
(Date:12/1/2015)... Burlington, MA (PRWEB) , ... December 01, 2015 , ... ... the release of Clarity, the latest addition to the devices for sale in the ... technologies, 755 nm Alexandrite and long-pulsed 1064 nm Nd:YAG lasers, into a single platform ...
(Date:12/1/2015)... ... , ... XTC Semifinals 2016 - CES, Las Vegas, Nevada - ... CES 2016, the world’s largest Consumer Electronic Show, where they will present to a ... of Pacific Investments Veronica Serra, and venture capitalist Tim Draper among many other top ...
(Date:12/1/2015)... , ... December 01, 2015 , ... Nurotron Biotechnology Co., ... its largest order to date. , The order will be from the China ... Venus Cochlear Implant System is an effective solution for children and adults suffering from ...
Breaking Medicine News(10 mins):