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Array Announces Global Phase 3 Trial Evaluating MEK162 In Patients With Low-Grade Serous Ovarian Cancer
Date:5/6/2013

domized Phase 3 trial will evaluate MEK162 against physician's choice of standard chemotherapy treatments in 300 patients with recurrent or persistent LGSOC following at least one prior platinum-based chemotherapy regimen and no more than three lines of prior chemotherapy regimens. The primary endpoint is progression-free survival, and the key secondary endpoint is overall survival.

"This trial is yet another indication of our continued progress towards our products being commercialized," said Ron Squarer, Chief Executive Officer, Array BioPharma.  "MEK162 is planned to be in three pivotal trials, which along with other ongoing and planned studies, is expected to position this drug to demonstrate its broad activity across a variety of tumor types."

As part of the agreement with Novartis, Array is entitled to royalties on worldwide sales, with royalties on U.S. sales at a higher level. Array is co-developing MEK162 with Novartis and retains an option to co-detail the product in the United States.

About Low-grade Serous Ovarian Cancer
Ovarian cancer is the tenth most common cancer among women, the fifth leading cause of cancer-related death among women, and is the deadliest of gynecologic cancers.  Serous ovarian cancer represents the largest group of ovarian cancer and is considered to consist of two main subtypes: low-grade and high-grade.  LGSOC represents up to 10 percent of ovarian cancer diagnoses, and it is estimated that over 10,000 women are living with the disease in the United States and Europe.  Patients with LGSOC are generally diagnosed at a younger age and live longer, but have a lower response rate to conventional chemotherapy compared to patients with high-grade serous ovarian cancer.  Management for advanced disease involves surgery and multiple anti-cancer regimens.  Less than 4 percent of patients with recurrent LGSOC respond to chemotherapy
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