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Arno Therapeutics to Present Positive, New Data Supporting the Potential of Onapristone in Endometrial and Breast Cancers at ASCO 2013 Annual Meeting
Date:5/15/2013

nt with APR positive cells in about a quarter (23% PRA; 22% PRB) of the breast cancer samples studied. The study also found that the IHC technique used to identify APR has the potential to be developed as a diagnostic test, which would help predict anti-progestin activity in patients with breast cancer.  

 

  • Independent characterization by duel staining of progesterone receptor (PR) and estrogen receptor (ER) in breast cancer (BC)
    Abstract #596; Poster #8C
    Poster session: Saturday, June 1; 1:15 – 5:00 p.m. CT; S Hall A2
    The study evaluated a total of 76 breast cancer samples to determine the expression of estrogen (ER) and progesterone receptors (PR) at the cellular level and to determine if ER and PR are expressed in the same breast cancer cells. Through a standard IHC testing procedure consisting of sequential double staining – the first with a duel anti-PR A/B antibody and ER antibody and the second with anti-ER and anti-PRA antibodies or anti-ER and anti-PRB antibodies – the study found that both ER and PR were expressed in the majority of tumors examined, but only a minority of the tumor cells expressed both receptors (ER and PR). ER and PR positivity was defined as 5 percent or more cells positive. Detailed findings were as follows:
  • In the initial testing of 13 tumors, 11 of 13 tumors were ER positive; 13 of 13 tumors were PR positive; seven of 13 tumor samples showed both ER and PR expression in 5-20 percent (median 5%) of the same tumor cells.
  • In the second series of testing with specific anti-ER and anti-PRA antibodies, both ER and PRA were expressed in 5-20 percent (median 5%) of the same tumor cells. Using the anti-ER and anti-PRB antibodies, ER and PRB expression was observed in 5-20 percent (median 10%) of the same tumor cells.
  • These findings support evaluating anti-progestins as a therapeutic target alone or in combination with anti-estrogens. 

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    SOURCE Arno Therapeutics, Inc.
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