Navigation Links
Arno Therapeutics to Present Positive, New Data Supporting the Potential of Onapristone in Endometrial and Breast Cancers at ASCO 2013 Annual Meeting
Date:5/15/2013

nt with APR positive cells in about a quarter (23% PRA; 22% PRB) of the breast cancer samples studied. The study also found that the IHC technique used to identify APR has the potential to be developed as a diagnostic test, which would help predict anti-progestin activity in patients with breast cancer.  

 

  • Independent characterization by duel staining of progesterone receptor (PR) and estrogen receptor (ER) in breast cancer (BC)
    Abstract #596; Poster #8C
    Poster session: Saturday, June 1; 1:15 – 5:00 p.m. CT; S Hall A2
    The study evaluated a total of 76 breast cancer samples to determine the expression of estrogen (ER) and progesterone receptors (PR) at the cellular level and to determine if ER and PR are expressed in the same breast cancer cells. Through a standard IHC testing procedure consisting of sequential double staining – the first with a duel anti-PR A/B antibody and ER antibody and the second with anti-ER and anti-PRA antibodies or anti-ER and anti-PRB antibodies – the study found that both ER and PR were expressed in the majority of tumors examined, but only a minority of the tumor cells expressed both receptors (ER and PR). ER and PR positivity was defined as 5 percent or more cells positive. Detailed findings were as follows:
  • In the initial testing of 13 tumors, 11 of 13 tumors were ER positive; 13 of 13 tumors were PR positive; seven of 13 tumor samples showed both ER and PR expression in 5-20 percent (median 5%) of the same tumor cells.
  • In the second series of testing with specific anti-ER and anti-PRA antibodies, both ER and PRA were expressed in 5-20 percent (median 5%) of the same tumor cells. Using the anti-ER and anti-PRB antibodies, ER and PRB expression was observed in 5-20 percent (median 10%) of the same tumor cells.
  • These findings support evaluating anti-progestins as a therapeutic target alone or in combination with anti-estrogens. 

    "Collectively,
    '/>"/>

    SOURCE Arno Therapeutics, Inc.
    Copyright©2012 PR Newswire.
    All rights reserved

    Page: 1 2 3 4 5 6

    Related medicine technology :

    1. Cell Therapeutics, Inc. (CTI) to Report First Quarter Financial Results on April 20
    2. Faruqi & Faruqi, LLP Encourages Investors Who Suffered Substantial Losses Investing in Chelsea Therapeutics International, Ltd. to Contact the Firm
    3. Argos Therapeutics Secures $25 million Series D Financing to Commence Phase 3 ADAPT Study in Patients with Metastatic Renal Cell Carcinoma (mRCC) in Mid-2012
    4. Novelos Therapeutics Announces Successful Completion of First Cohort In Lung Cancer Trial With I-124-CLR1404 (LIGHT) Cancer-Targeted PET Imaging Agent at UW Carbone Cancer Center
    5. Zacks Industry Outlook Highlights: Eli Lilly, Forest Labs, ViroPharma, Novartis and United Therapeutics
    6. Oxford BioTherapeutics Appoints Senior Industry Leader to Head its New Clinical Development Operations in Basel, Switzerland
    7. Nektar Therapeutics Reports Financial Results for the First Quarter of 2012
    8. Cara Therapeutics Licenses Novel Kappa Opioid Agonist, CR845, to Chong Kun Dang Pharmaceutical Corporation For South Korean Market
    9. Frost & Sullivan: High Uptake of New Drug Therapies and Aging Population Expansion Keep the U.S. Retinal Therapeutics Market Buoyant
    10. Zenobia Therapeutics, Inc. And BioBlocks, Inc. Announce Sale Of A Joint Fragment Library Ideal For Screening By All Popular Methods
    11. New Forecast Shows Global Protein Therapeutics Market to Reach $143.4 Billion by 2015
    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    (Date:7/11/2014)... July 11, 2014  Australian drug delivery company, Phosphagenics ... has raised A$19.3 million via a placement of A$16.3 ... , the U.S., Asia and ... a share purchase plan (SPP) to be offered to ... made in two tranches. "This capital raising ...
    (Date:7/11/2014)... DUBLIN , July 11, 2014 ... the addition of the "Immunoprotein Diagnostic Testing ... at the highest CAGR of 6% and is ... report to their offering. ... for immunoprotein diagnostic testing has been segmented according ...
    (Date:7/11/2014)... July 11, 2014 Neurelis, Inc. ("Neurelis") today ... end the option held by Biotie to purchase Neurelis, ... of NRL-1 (intranasal diazepam) for pediatric and adult epilepsy ... the past year, Biotie has advanced the development program ... the pivotal clinical work required for NDA submission to ...
    Breaking Medicine Technology:Phosphagenics' A$19.3 million Capital Raising 2Phosphagenics' A$19.3 million Capital Raising 3Immunoprotein Diagnostic Testing Market - Forecasts to 2019: Expected to grow at the highest CAGR of 6% and is expected to be valued at USD 4,943.0 million 2Neurelis Regains Rights to Intranasal Diazepam Program 2Neurelis Regains Rights to Intranasal Diazepam Program 3
    ... 13 Allscripts (Nasdaq: MDRX ... results for the three and nine months ended September ... Monday, November 8, 2010. Allscripts management will host a ... and other information at 4:30 PM Eastern Standard Time ...
    ... Academy of Managed Care Pharmacy (AMCP) 2010 Educational ... Express Scripts (Nasdaq: ESRX ) will ... driving down healthcare costs and providing increased value ... (Logo:   http://photos.prnewswire.com/prnh/20080827/EXPRESSSCRIPTSLOGO ) (Logo:   ...
    Cached Medicine Technology:Allscripts to Announce Third Quarter 2010 Results on November 8, 2010 2Allscripts to Announce Third Quarter 2010 Results on November 8, 2010 3Express Scripts Unveils New Opportunities to Drive Down Healthcare Costs; Presents Five Studies at Academy of Managed Care Pharmacy Conference 2Express Scripts Unveils New Opportunities to Drive Down Healthcare Costs; Presents Five Studies at Academy of Managed Care Pharmacy Conference 3
    (Date:7/12/2014)... 2014 The "North ... Devices Market by Angioplasty Balloon (Plain/Old, ... OCT), IVC Filter (Retrievable), Endovascular Stent ... and studies the major market drivers, ... and Canada. , Browse 108 market ...
    (Date:7/12/2014)... The fastest-growing mobile technology is LTE ... of LTE networks continues to grow due to the ... have increased mobile data traffic, which is a major ... Communications Test and Measurement equipment comply with industry standards, ... Test and Measurement Market is estimated to grown from ...
    (Date:7/12/2014)... injuries increase in the summer as people gather around fire ... most vulnerable to these seasonal fire hazards: children. "Young ... by putting their hands on the side of cooking grills," ... Loyola University Medical Center in Maywood, Ill., said in a ... play with fire, you get burned, is true -- ...
    (Date:7/12/2014)... Using and carrying around a catheter bag can ... Va., decided that there needed to be an inconspicuous ... of our design," he said. , They then created ... an inconspicuous way to use and carry a catheter’s ... comfort and peace of mind. Producible in design variations, ...
    (Date:7/12/2014)... Wright & Schulte LLC has filed a ... a subsidiary of Johnson & Johnson, on behalf of an ... receiving a metal-on-metal DePuy Pinnacle hip replacement and had to ... hip implant. The DePuy hip lawsuit was filed July 7, ... (Case No. 3:14-cv-2427) where DePuy Pinnacle Hip lawsuit litigation ...
    Breaking Medicine News(10 mins):Health News:North American Interventional Cardiology & Peripheral Vascular Devices Market - New Report by MarketsandMarkets 2Health News:North American Interventional Cardiology & Peripheral Vascular Devices Market - New Report by MarketsandMarkets 3Health News:North American Interventional Cardiology & Peripheral Vascular Devices Market - New Report by MarketsandMarkets 4Health News:North American Interventional Cardiology & Peripheral Vascular Devices Market - New Report by MarketsandMarkets 5Health News:North America Communication Test and Measurement (CT&M) Market Worth $1.9 Billion by 2018 - New Report by MicroMarket Monitor 2Health News:North America Communication Test and Measurement (CT&M) Market Worth $1.9 Billion by 2018 - New Report by MicroMarket Monitor 3Health News:North America Communication Test and Measurement (CT&M) Market Worth $1.9 Billion by 2018 - New Report by MicroMarket Monitor 4Health News:North America Communication Test and Measurement (CT&M) Market Worth $1.9 Billion by 2018 - New Report by MicroMarket Monitor 5Health News:Burn Injuries More Common in Summer 2Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 2Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 3Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 4Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 5
    ... pros, cons to make informed choice about prostate cancer test, ... inability of the prostate specific antigen (PSA) test to distinguish ... a population-wide screening tool, new research claims. , Because of ... overtreatment, according to two reports in the Sept. 25 online ...
    ... In the future, diagnosing severe personality disorders, evaluating ... analysis of the MAOA genotype may provide more ... according to the Finnish research carried out jointly ... University Central Hospital Psychiatry Centre. "The many ...
    ... damage more than just your smile? Can failing to attack ... answer to both questions may be yes if you are ... published in the current issue of the Journal of ... Kowolik, B.D.S., Ph.D., professor of periodontics and associate dean for ...
    ... punishment can affect psychological well-being, , FRIDAY, Sept. 25 (HealthDay ... spanked might lose IQ points. , The good news is ... -- and at least one expert believes that part of ... of favor in the United States and elsewhere. , That,s ...
    ... ... 1. Practitioner Training: Friday, October 30 , ... Buffalo, NY (PRWEB) September 25, 2009 -- The U.S. Centers ... in the U.S. have an Autism Spectrum Disorder (ASD), which includes autism, Asperger syndrome, ...
    ... ... Present Completion of New Emergency 911 Center , ... Pittsburgh, PA (PRWEB) September 25, 2009 ... 2009 in San Francisco the firm,s ground-breaking renovation of Washington County,s Emergency 911 ...
    Cached Medicine News:Health News:Studies Find PSA Screening Unreliable 2Health News:Studies Find PSA Screening Unreliable 3Health News:New ways to predict violent behavior? 2Health News:Body's immune system response to dental plaque varies by gender and race 2Health News:Spanking May Lower Kids' IQs 2Health News:Spanking May Lower Kids' IQs 3Health News:AutismOne & Autism Canada Present "CHANGING THE COURSE OF AUTISM IN CANADA 2009" University of Toronto 2Health News:AutismOne & Autism Canada Present "CHANGING THE COURSE OF AUTISM IN CANADA 2009" University of Toronto 3Health News:synergIT Presents at VMworld 2009 in San Francisco 2Health News:synergIT Presents at VMworld 2009 in San Francisco 3
    For implantation in proximal interphalangeal joints of the lateral toes to correct deformity associated with degenerative or rheumatoid arthritis....
    Part of the GraFix® Cruciate Reconstruction System, which is designed to facilitate arthroscopic anterior cruciate ligament reconstructions....
    ... a new standard in the field of hammertoe ... Made of medical grade silicone, these durable and ... high level of flexibility while maintaining correct toe ... in varying stiffnesses. Lengths are determined by the ...
    ... Kinetik Great Toe Implant (KGTI) system offers ... of the first MPJ. The implant system ... of motion. , ,The KGTI is the ... metatarsophalangeal joint (MPJ) on the market today. ...
    Medicine Products: