Navigation Links
Arno Therapeutics to Present Positive, New Data Supporting the Potential of Onapristone in Endometrial and Breast Cancers at ASCO 2013 Annual Meeting
Date:5/15/2013

nt with APR positive cells in about a quarter (23% PRA; 22% PRB) of the breast cancer samples studied. The study also found that the IHC technique used to identify APR has the potential to be developed as a diagnostic test, which would help predict anti-progestin activity in patients with breast cancer.  

 

  • Independent characterization by duel staining of progesterone receptor (PR) and estrogen receptor (ER) in breast cancer (BC)
    Abstract #596; Poster #8C
    Poster session: Saturday, June 1; 1:15 – 5:00 p.m. CT; S Hall A2
    The study evaluated a total of 76 breast cancer samples to determine the expression of estrogen (ER) and progesterone receptors (PR) at the cellular level and to determine if ER and PR are expressed in the same breast cancer cells. Through a standard IHC testing procedure consisting of sequential double staining – the first with a duel anti-PR A/B antibody and ER antibody and the second with anti-ER and anti-PRA antibodies or anti-ER and anti-PRB antibodies – the study found that both ER and PR were expressed in the majority of tumors examined, but only a minority of the tumor cells expressed both receptors (ER and PR). ER and PR positivity was defined as 5 percent or more cells positive. Detailed findings were as follows:
  • In the initial testing of 13 tumors, 11 of 13 tumors were ER positive; 13 of 13 tumors were PR positive; seven of 13 tumor samples showed both ER and PR expression in 5-20 percent (median 5%) of the same tumor cells.
  • In the second series of testing with specific anti-ER and anti-PRA antibodies, both ER and PRA were expressed in 5-20 percent (median 5%) of the same tumor cells. Using the anti-ER and anti-PRB antibodies, ER and PRB expression was observed in 5-20 percent (median 10%) of the same tumor cells.
  • These findings support evaluating anti-progestins as a therapeutic target alone or in combination with anti-estrogens. 

    "Collectively,
    '/>"/>

    SOURCE Arno Therapeutics, Inc.
    Copyright©2012 PR Newswire.
    All rights reserved

    Page: 1 2 3 4 5 6

    Related medicine technology :

    1. Cell Therapeutics, Inc. (CTI) to Report First Quarter Financial Results on April 20
    2. Faruqi & Faruqi, LLP Encourages Investors Who Suffered Substantial Losses Investing in Chelsea Therapeutics International, Ltd. to Contact the Firm
    3. Argos Therapeutics Secures $25 million Series D Financing to Commence Phase 3 ADAPT Study in Patients with Metastatic Renal Cell Carcinoma (mRCC) in Mid-2012
    4. Novelos Therapeutics Announces Successful Completion of First Cohort In Lung Cancer Trial With I-124-CLR1404 (LIGHT) Cancer-Targeted PET Imaging Agent at UW Carbone Cancer Center
    5. Zacks Industry Outlook Highlights: Eli Lilly, Forest Labs, ViroPharma, Novartis and United Therapeutics
    6. Oxford BioTherapeutics Appoints Senior Industry Leader to Head its New Clinical Development Operations in Basel, Switzerland
    7. Nektar Therapeutics Reports Financial Results for the First Quarter of 2012
    8. Cara Therapeutics Licenses Novel Kappa Opioid Agonist, CR845, to Chong Kun Dang Pharmaceutical Corporation For South Korean Market
    9. Frost & Sullivan: High Uptake of New Drug Therapies and Aging Population Expansion Keep the U.S. Retinal Therapeutics Market Buoyant
    10. Zenobia Therapeutics, Inc. And BioBlocks, Inc. Announce Sale Of A Joint Fragment Library Ideal For Screening By All Popular Methods
    11. New Forecast Shows Global Protein Therapeutics Market to Reach $143.4 Billion by 2015
    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    (Date:5/6/2015)... 2015 Neuralstem, Inc. (NYSE MKT: CUR), a ... small molecule and cell therapy treatments for central nervous ... Jones to the position of Chief Financial Officer, ... Lloyd Jones brings to the position more ... experience.   Most recently, Mr. Lloyd Jones served ...
    (Date:5/6/2015)... 2015 AbbVie (NYSE: ABBV ) will ... Health Care Conference on Wednesday, May 13, 2015. ... will participate in a question and answer session at ... webcast of the presentation will be accessible through AbbVie,s ... archived edition of the session will be available later ...
    (Date:5/6/2015)... , May 6, 2015   Symbiomix Therapeutics ... the third and final tranche of a $41 million ... randomized Phase 2 trial testing a single oral dose ... Based on discussions with the U.S. Food and Drug ... now is planning to submit the Phase 2 trial ...
    Breaking Medicine Technology:Neuralstem Appoints Jonathan Lloyd Jones as Chief Financial Officer 2Neuralstem Appoints Jonathan Lloyd Jones as Chief Financial Officer 3Neuralstem Appoints Jonathan Lloyd Jones as Chief Financial Officer 4Symbiomix Therapeutics Announces Closing of $41M Financing and Positive Results from a Pivotal Phase 2 Trial of SYM-1219 for the Treatment of Bacterial Vaginosis 2Symbiomix Therapeutics Announces Closing of $41M Financing and Positive Results from a Pivotal Phase 2 Trial of SYM-1219 for the Treatment of Bacterial Vaginosis 3Symbiomix Therapeutics Announces Closing of $41M Financing and Positive Results from a Pivotal Phase 2 Trial of SYM-1219 for the Treatment of Bacterial Vaginosis 4Symbiomix Therapeutics Announces Closing of $41M Financing and Positive Results from a Pivotal Phase 2 Trial of SYM-1219 for the Treatment of Bacterial Vaginosis 5
    (Date:5/6/2015)... California (PRWEB) May 06, 2015 ... hand sanitizers are increasing, driven by the rising consumer ... the spread of contagious diseases. Hand washing is becoming ... of consumer apprehension over contracting infections. Periodic outbreak of ... the recent Ebola virus disease (EVD) epidemic ...
    (Date:5/6/2015)... (PRWEB) May 06, 2015 In March, ... at the 8th Milano Masterclass. As Europe’s most exclusive ... elite plastic surgeons. Dr. Batniji was hand chosen to ... Plastic and Reconstructive Surgery, Dr. Pietro Palma. , ... Italy. The conference hosts a diverse, multi-national faculty; each ...
    (Date:5/6/2015)... AZ (PRWEB) May 06, 2015 The ... open for League Corporate Partner booth selection . ... and services to community college and university decision-makers from ... place November 1-4, 2015, at the Arizona Grand in ... private desert oasis on the doorstep of the South ...
    (Date:5/6/2015)... GA (PRWEB) May 06, 2015 ... chosen Hexagon Geospatial technology to manage and distribute imagery, ... Australia is one of the driest continents on earth, ... through times of drought and erratic seasonal rainfalls has ... supply solutions. , Water NSW manages raw water supplies ...
    (Date:5/6/2015)... The Florida Council on Compulsive Gambling, Inc. (FCCG), ... Area Geriatric Education Center, Mental Health Association of Southeast ... Substance Abuse, will hold its annual conference in Ft ... Hotel. , This important event will address topics such ... as clinical training for problem gambling treatment services. ...
    Breaking Medicine News(10 mins):Health News:Growing Apprehension Amid Disease Outbreaks Drives Global Sales of Hand Sanitizers, According to a New Report by Global Industry Analysts, Inc. 2Health News:Growing Apprehension Amid Disease Outbreaks Drives Global Sales of Hand Sanitizers, According to a New Report by Global Industry Analysts, Inc. 3Health News:Growing Apprehension Amid Disease Outbreaks Drives Global Sales of Hand Sanitizers, According to a New Report by Global Industry Analysts, Inc. 4Health News:California Surgeon Speaks at International Rhinoplasty Conference 2Health News:STEMtech Conference Exhibitors Gain Access to Community College and University Representatives From Across the U.S. 2Health News:Water NSW Unlocks Imagery and Elevation Data Archive Across the Enterprise using Hexagon Geospatial Solutions 2Health News:Water NSW Unlocks Imagery and Elevation Data Archive Across the Enterprise using Hexagon Geospatial Solutions 3Health News:Conference on Problem Gambling to be held in Ft. Lauderdale, FL 2
    ... can a pediatric urologist researching intersexuality learn from a forensic ... own ways to make more informed decisions, but rarely do ... Now, for the first time, leading practitioners ... from national security, business, education, medicine, forensics and the law ...
    ... ... ... -- Advocate Health Care, a not-for-profit, faith-based health care system, today announced it provided ... than one-million lives touched in the communities it serves throughout Chicagoland and a substantial ...
    ... PICK: Identifying preterm infants at risk of life-threatening conditions ... to life-threatening conditions that are clinically difficult to detect. ... microbes are present in the blood, and necrotizing enterocolitis, ... But now, Terrence Poon and colleagues, at the The ...
    ... Leading Youth ... , ... -- O2 MAX Fitness , a youth fitness brand focused on addressing the unmet fitness ... unveil a whole new line of initiatives aimed at helping the college female this year. According ...
    ... ... fatigue syndrome” without the negative side effects of caffeine? Need to ... Energy, the caffeine- and sugar- free vegetarian capsules made of all ... may boost memory and drive metabolism, among other health benefits. PureStart ...
    ... July 1, 2010 The Damon Runyon Cancer ... Investigators at its April 2010 Clinical Investigator Award ... three-year award are outstanding early career physician-scientists conducting ... the mentorship of the nation,s leading scientists and ...
    Cached Medicine News:Health News:Knowledge workers divulge trade secrets at Global Intelligence Forum 2Health News:Advocate Health Care Reports $462 Million in Community Benefits 2Health News:Advocate Health Care Reports $462 Million in Community Benefits 3Health News:JCI online early table of contents: July 1, 2010 2Health News:JCI online early table of contents: July 1, 2010 3Health News:JCI online early table of contents: July 1, 2010 4Health News:JCI online early table of contents: July 1, 2010 5Health News:JCI online early table of contents: July 1, 2010 6Health News:JCI online early table of contents: July 1, 2010 7Health News:Fighting Off the Freshman Fifteen 2Health News:Fighting Off the Freshman Fifteen 3Health News:DecafaLife, LLC Announces New All-Natural Product to Keep You Energized While Kicking Your Caffeine Habit 2Health News:Damon Runyon Cancer Research Foundation awards $3.1M to 8 top young clinical investigators 2Health News:Damon Runyon Cancer Research Foundation awards $3.1M to 8 top young clinical investigators 3Health News:Damon Runyon Cancer Research Foundation awards $3.1M to 8 top young clinical investigators 4Health News:Damon Runyon Cancer Research Foundation awards $3.1M to 8 top young clinical investigators 5Health News:Damon Runyon Cancer Research Foundation awards $3.1M to 8 top young clinical investigators 6
    The HEP-1 system accommodates mini to full size gels with a transfer area of 20cmWx 20cmL, designed specifically for the transfer from polyacrylamide or agarose gels....
    ... from agarose gels to hybridization membranes in ... and efficiency of transfer by allowing high ... of an integrated system allowing electrophoresis, gel ... hours, versus 29 hours required for conventional ...
    Trans-Blot Plus Gel/Cassette Assembly Tray...
    A blotter fit for use with the incredible new Criterion precast gel system, the Criterion blotter combines excellent blotting efficiency with the flexibility of the Trans-Blot system and the ease-of-...
    Medicine Products: