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Arno Therapeutics to Present Positive, New Data Supporting the Potential of Onapristone in Endometrial and Breast Cancers at ASCO 2013 Annual Meeting
Date:5/15/2013

and president, Arno Therapeutics. "These data add to the growing body of knowledge indicating the potential of the compound to fill a high unmet medical need and we plan to pursue a global orphan drug designation in endometrial cancer."

The findings will be presented during the following poster presentations:

  • Determination of activated form of progesterone receptor (PR) in endometrial cancer (EC)
    Abstract #5602; Poster #53H
    Poster session: Monday, June 3; 8:00 – 11:45 a.m. CT; S Hall A2
    The study evaluated 72 archived primary endometrial cancer samples to determine if APR can be identified in endometrial cancer and if a technique called immunohistochemistry (IHC) - developed to identify APR in breast cancer - could be used to identify APR positive cells in the endometrial cancer samples. It found that APR can be identified using antibodies specific to the A and B isoforms of the PR (PRA and PRB) and in approximately 40-45 percent of the endometrial cancer samples studied, there was a pattern consistent with the presence of APR positive cells. APR was defined as any tumor with more than 5 percent APR positive cells, which were identified by an aggregated PR nuclear distribution pattern. The study found that the IHC technique used to identify APR has the potential to be developed as a diagnostic test, which may help predict anti-progestin anti-tumor activity in patients with endometrial cancer.
  •  

  • Identification of the activated form of progesterone receptor (PR) in breast cancer (BC)
    Abstract #593; Poster #7H
    Poster session: Saturday, June 1; 1:15 – 5:00 p.m. CT; S Hall A2
    The study examined 303 archival breast cancer samples processed with PRA and PRB isotype specific antibodies to determine the feasibility of an IHC method for use as a biomarker test to identify the expression of APR in breast cancer. The developed IHC and analytical technique identified a nuclear morphology pattern consiste
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  • SOURCE Arno Therapeutics, Inc.
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