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Arno Therapeutics to Present Positive, New Data Supporting the Potential of Onapristone in Endometrial and Breast Cancers at ASCO 2013 Annual Meeting
Date:5/15/2013

FLEMINGTON, N.J., May 15, 2013 /PRNewswire/ -- Arno Therapeutics, Inc. (OTCQB: ARNI), a clinical stage biopharmaceutical company focused on the development of oncology therapeutics, today announced new, positive data from three studies supporting its investigational compound onapristone to be presented at the American Society of Clinical Oncology (ASCO) 2013 Annual Meeting, which is being held May 31-June 4, 2013 in Chicago, Illinois.

Three separate preclinical studies support further investigation of onapristone - an orally-administered, investigational type 1 progestin receptor antagonist - and the development of a diagnostic test for the compound to identify patients with activated progesterone receptor (APR) as a potential biomarker of anti-progestin activity in endometrial and breast cancers.  Recently, Arno Therapeutics announced its collaboration with Clarient Diagnostic Services Inc., a GE healthcare company, and leading provider of cancer diagnostic testing, to develop a diagnostic test to identify cancerous tumors with APR.

Onapristone is believed to work by binding to a protein called the progesterone receptor, thereby inhibiting dimerization, phosphorylation and DNA transcription activity. Progesterone receptors (PRs) are found in particular cells including those of the female reproductive tissue and some cancers.[i] The hormone progesterone binds to the receptors and may cause the cells to grow.i  Preclinical studies have shown that PRs can play a role as drivers of malignant cell growth in certain cancers."We are pleased with the findings as they support the development of a diagnostic test for onapristone to help identify patients with activated progesterone receptors in endometrial and breast cancers who are most likely to benefit from treatment in these difficult-to-treat diseases," said Glenn Mattes , chief executive officer
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SOURCE Arno Therapeutics, Inc.
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