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Army Researcher Develops Potential Vaccine Carrier That May Give Stockpiling Efforts A Shot In The Arm
Date:4/22/2012

SAN DIEGO, April 22, 2012 /PRNewswire/ -- A researcher at the Brooke Army Medical Center (BAMC)/San Antonio Military Medical Center (SAMMC) will present findings this week on a new potential vaccine carrier that he hopes will extend the shelf life of and aid in the stockpiling of critical vaccines.

U.S. Army Maj. Jean M. Muderhwa is slated to present at 12:25 p.m. Sunday, April 22, at the Experimental Biology 2012 meeting on a microemulsion he developed and that has been found to be both stable and a good candidate for delivering a variety of antigens. His findings will be presented at the American Society for Biochemistry and Molecular Biology's annual meeting, which is part of EB2012.

"There is a synergy here," Muderhwa said of the microemulsion. "What I found is a composition that is transparent, is liquid and that has been sitting there (on my shelf) for six months" without degrading.

Muderhwa, deputy laboratory director at the Medical Center's Clinical Investigation Department, made the microemulsion with what seems like a simple recipe with five components, but it's how those five components interact that is quite special. He is hopeful that forthcoming animal studies will show the full potential for the recipe.

"There is a need (for new vaccine carriers like this) especially if we want to stockpile a vaccine," he emphasized. "The (U.S. Agency for International Development) and FDA are responsible for stocking, for example, the influenza vaccine in the case of epidemic. They have to deliver them as quickly as possible. So if you have a vaccine just sitting on the shelf for more than 10 or 20 years, you don't have to worry about its stability."

The first two parts of Muderhwa's concotion, oil and water, are the basis for just about any emulsion, many of which reside in most people's bathroom cabinets in the forms of creams and lotions. The third component, glycerol, is also used in a variety of skin-care products. The
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SOURCE American Society for Biochemistry and Molecular Biology
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