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Arisaph Pharmaceuticals Reports Positive Results From Two Safety Clinical Trials For Its Niacin Analog (ARI-3037MO)
Date:11/7/2012

BOSTON, Nov. 7, 2012 /PRNewswire/ --

  • ARI-3037MO was well tolerated in single and repeat ascending dose trials in healthy volunteers
  • ARI-3037MO did not provoke flushing or any other treatment-related adverse effects in 58 healthy male and female volunteers
  • ARI-3037MO was well absorbed orally and plasma levels demonstrated good dose proportionality
  • ARI-3037MO showed encouraging lipid changes in both clinical trials in healthy subjects
  • Arisaph Pharmaceuticals, Inc. announced today during an oral presentation at the American Heart Association (AHA) meeting in Los Angeles, CA that its niacin analog, ARI-3037MO, was extremely well tolerated in a single-ascending dose (SAD) and a multiple-ascending dose (MAD) trial in healthy male and female volunteers.  The results showed that ARI-3037MO did not provoke flushing or any other adverse skin changes, nor did it cause increases in liver enzymes or blood glucose at doses up to 6 grams per day. In both clinical trials, ARI-3037MO also demonstrated encouraging lipid effects. Based on these promising results, ARI-3037MO potentially represents a transformational, new niacin-like option for treatment of patients with dyslipidemia, especially in the setting of metabolic syndrome, a disorder that afflicts as many as 70 million Americans1

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    "The absence of flushing and other niacin induced adverse events highlights a differentiated safety profile for our novel niacin analog," said Christopher P. Kiritsy, Co-Founder, President and Chief Executive Officer of Arisaph Pharmaceuticals. "Moreover, the evidence of lipid changes in such short duration trials in healthy volunteers shows that our preclinical efficacy data are translating and breeds optimism for the development of our best-in-class niacin analog."In two placebo co
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    SOURCE Arisaph Pharmaceuticals, Inc.
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