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Argen-X Launches NHance™ Technology to Generate Better Human Antibody Therapies
Date:3/19/2012

ROTTERDAM, the Netherlands and GHENT, Belgium, March 19, 2012 /PRNewswire/ --

ADDS A SECOND PROPRIETARY TECHNOLOGY TO LEVERAGE THE POWER OF THE SIMPLE ANTIBODY™ PLATFORM  

arGEN-X announces today the launch of NHance™, its latest cutting-edge technology enabling the creation of truly differentiated human antibody therapeutics.

NHance™ technology significantly prolongs the circulation time of therapeutic antibodies in the human body by engineering of the antibody constant region (Fc). The technology provides a new treatment paradigm in terms of reduced antibody dosing, increased efficacy and improved overall convenience to the patient.

Nhance™ is superior to existing Fc engineering approaches delivering superior pharmacokinetics without impairing the antibody's Fc-mediated cell-killing effects. The technology has been thoroughly validated, including through PK studies in appropriate pre-clinical models.

NHance™ is based on proprietary Fc region mutations and was invented by Dr. Sally Ward, Professor of Immunology at the University of Texas Southwestern Medical Center, a world renowned pioneer in this field of antibody biology. arGEN-X has acquired an exclusive global license to the technology.

arGEN-X will apply the NHance™ technology both to its partners' antibody discovery programs and to its own therapeutic antibody pipeline. In addition, arGEN-X intends to make the technology available to antibody-focused companies through non-exclusive licenses.

"Our validated SIMPLE Antibody™ platform, which delivers variable regions unrivalled in their functional diversity and therapeutic utility, is key to arGEN-X's success," says Prof. Dr. Hans de Haard, Chief Scientific Officer. "We had previously complemented the SIMPLE platform with state-of-the-art ADCC-enhancement through our Potelligent® license agreement with BioWa. We are now further strengthening our cu
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