Navigation Links
Arena Pharmaceuticals Reports Positive, Highly Significant BLOSSOM Trial Results for Weight Management; NDA Submission on Track for December
Date:9/17/2009

h occurred in the placebo group, no SAEs of seizure were reported and the number of neuropsychiatric SAEs in lorcaserin patients did not exceed the number in the placebo group.

Cardiovascular Safety

The integrated BLOOM and BLOSSOM echocardiography data set rules out a risk of valvulopathy in lorcaserin patients according to criteria requested by the FDA. Echocardiographic evaluations showed no association between lorcaserin and the development of heart valve insufficiency. Rates of new FDA-defined valvulopathy in BLOSSOM at Week 52 were as follows: lorcaserin 10 mg twice daily (2.0%), 10 mg once daily (1.4%) and placebo (2.0%).

"The echocardiographic safety data show no risk of valvulopathy," commented Neil J. Weissman, M.D., Director, Cardiac Ultrasound and Ultrasound Core Labs, President, MedStar Research Institute, and Professor of Medicine, Georgetown University. "In the individual and combined BLOOM and BLOSSOM data sets there is no evidence of a difference in the development of valve disease in lorcaserin patients versus control for up to two years of continuous use. No prospective echocardiographic program has ever studied this many patients for this period of time."

Secondary Endpoints

Treatment with lorcaserin over one year was associated with significant improvements or strongly favorable trends compared to placebo in multiple secondary endpoints, including blood pressure and lipids.

Patient Disposition

BLOSSOM evaluated 4,008 patients with an average body mass index, or BMI, of 35.9 and baseline weight of 220 pounds. The Week 52 completion rate was higher for patients on lorcaserin 10 mg twice daily (57.2%) and 10 mg once daily (59.0%) compared to patients on placebo (52.0%). Discontinuations for adverse events were low and as follows: lorcaserin 10 mg twice daily (7.2%), 10 mg once daily (6.2
'/>"/>

SOURCE Arena Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10 11 12

Related medicine technology :

1. Arena Pharmaceuticals to Present at Four Upcoming Investor Conferences
2. Arena Pharmaceuticals Announces Positive Phase 2 Clinical Trial Results of APD125 for the Treatment of Insomnia
3. Arena Pharmaceuticals Announces APD668 Initial Clinical Study Results Suggest Glucose-Dependent Insulinotropic Receptors May Improve Glucose Control in Patients With Type 2 Diabetes
4. Arena Pharmaceuticals Announces Positive Phase 1a Clinical Trial Results of APD791 for the Treatment of Arterial Thrombosis and Initiates Phase 1b Clinical Trial
5. Arena Pharmaceuticals Initiates Phase 2b Clinical Trial of APD125 for the Treatment of Insomnia
6. Arena Pharmaceuticals, Inc. Announces Initiation of Phase 1 Clinical Trial of Drug Candidate Under Partnership with Taisho Pharmaceutical Co., Ltd.
7. Arena Pharmaceuticals Presented Positive Phase 2a Clinical Trial Results of APD125 for the Treatment of Insomnia at 22nd Annual Meeting of the Associated Professional Sleep Societies
8. Arena Pharmaceuticals Announces Positive Phase 1b Clinical Trial Results of APD791 for the Treatment of Arterial Thrombosis
9. Critical Pharmaceuticals Enter Sustained Release hGH Arena
10. Arena Pharmaceuticals Announces Preliminary Results of Phase 2b Clinical Trial of APD125 for the Treatment of Insomnia
11. Arena Pharmaceuticals Announces Initiation of Phase 1 Clinical Trial of Type 2 Diabetes Drug Candidate in Partnership with Ortho-McNeil-Janssen Pharmaceuticals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/26/2014)... , Nov. 26, 2014 Scott Steiger ... most of the world. As an engineer for the past 20 ... member of the military service. He,s been to six of the ... Photo - http://photos.prnewswire.com/prnh/20141126/161076 Photo - http://photos.prnewswire.com/prnh/20141126/161077 ... for travelers, he has a pretty good idea of what,s required. ...
(Date:11/26/2014)... -- Zynerba Pharmaceuticals , Inc., a specialty pharmaceutical ... cannabinoid treatments, today announced that the company will present ... The conference will be held December 2 to 3, ... York . Zynerba,s Chairman and CEO, Armando ... December 2. To listen to a webcast ...
(Date:11/26/2014)... , Nov. 26, 2014 The ... at a rate of 4%, with world market ... Kalorama Information. MRI and other types of medical ... and treatment of numerous medical conditions in children ... and techniques. Kalorama,s report, Medical Imaging Markets ...
Breaking Medicine Technology:Steiger Has Created the First Pill Case Specifically Designed For Travel 2Zynerba Pharmaceuticals to Present at Piper Jaffray 26th Annual Healthcare Conference 2014 2Kalorama: Steady Growth in the Medical MRI Market 2Kalorama: Steady Growth in the Medical MRI Market 3
... , , SEATTLE, Dec. 9 Omeros Corporation today ... to serve on the Company,s Board. Mr. Spiegelman has also been ... are very pleased to welcome Dan to our Board and look ... CEO of Omeros. "Dan brings a substantial depth and breadth of ...
... , WALTHAM, Mass., Dec. 9 Decision ... focusing on pharmaceutical and healthcare issues, finds that compared to ... are being used more often to treat newly diagnosed patients ... second-line patients received a TNF-alpha inhibitor versus one year ago ...
Cached Medicine Technology:Daniel K. Spiegelman Elected to Board of Directors of Omeros 2TNF-Alpha Inhibitors Are Being Used More Often To Treat Newly Diagnosed Patients With Crohn's Disease 2TNF-Alpha Inhibitors Are Being Used More Often To Treat Newly Diagnosed Patients With Crohn's Disease 3
(Date:11/28/2014)... Recently, BellasDress , a renowned dress manufacturer in the ... of cocktail dresses. In addition, these fresh dresses are available ... shipping on orders over $179. The aim of the special ... providing many styles of dresses, which come in various colors; ... more. All of them are on sale at affordable prices. ...
(Date:11/28/2014)... November 29, 2014 Recently, SWAccessControl.com, a ... systems. At the moment, all these high end products ... off. The special offer will last from today to ... “We are happy to launch the promotion. We are ... worldwide distributors with the latest information about our hottest ...
(Date:11/28/2014)... Recently, PrettyTailor.com has developed and created its new collection ... world in celebration of the coming holiday season. To ... special offer on all these outfits. Click here ... the garment industry, PrettyTailor.com brings together art and technology ... The business carries quite a few in eye-catching patterns ...
(Date:11/28/2014)... The month of December has the highest ... occurring in Florida every year in December , attorney Sean ... insurance policies. , "Optional auto insurance coverage is something you ... cheap I know, actually Florida is among the states, where ... but what I see is that the insurance required by ...
(Date:11/28/2014)... News) -- People with diabetes face a number of challenges ... healthy, an expert says. "With the holidays coming, take ... events, the family you,ll be visiting and all of the ... Educators, said in an association news release. "By planning ahead. ... One idea is to make a healthy eating contract with ...
Breaking Medicine News(10 mins):Health News:BellasDress Offers A Big Surprise By Updating Its Cheap and Charming Cocktail Dresses 2Health News:New Access Control Systems Now Offered At Low Prices By Smartware Manufacturer SWAccessControl.com 2Health News:2015 Wedding Dresses from PrettyTailor.com Available Now 2Health News:Car Accident Attorney Sean M. Cleary on Auto Insurance Policies Essential for Florida Drivers 2Health News:Holiday Eating Tips for People With Diabetes 2
... sedimentation rate (ESR) increases during pregnancy. Also, both ... ,The erythrocyte sedimentation rate is one of ... is helpful in detecting the presence of inflammation ... by anaemia, which may be present in inflammatory ...
... to be in critical condition in a hospital here where ... government said. // ,Narayanan, who turned 85 ... and Referral Hospital two days later and has been on ... his condition. He continues to be critical, the aide said. ...
... are now produced which has been found to have ... Immunotherapy vaccines. //Antibodies against the allergen is given as ... allergen or infection these antibodies which are already present ... ,Conventional antibody injections against allergy diseases such ...
... the November issue of the Journal of the National Cancer ... after treatment, and patients treated with the higher chemotherapy dose ... ,Germ-cell testicular cancer is the most common cancer among 20-40 ... an age at which they are starting a family, and ...
... is a FDA approved long-term treatment regime for patients ... therapy is now being offered to patients at NewYork-Presbyterian ... now the first treatment specifically approved for TRD in ... therapy has been unsuccessful atleast in four or more ...
... cancer does not mean that you can cool your heels, ... experts have warned people. // ,These warnings were ... by eminent doctors who took part in a panel discussion ... In a keynote address delivered on the occasion, Prof D ...
Cached Medicine News:Health News:Oral Edible vaccine for Allergy Vaccines 2Health News:Decline in Paternity Rates Following Treatment for Testicular Cancer 2Health News:FDA Approved Nerve-Stimulation Therapy Now Available In New York 2
... Infinity Triglycerides powder reagent once reconstituted ... of single liquid stability to help ... and provide quick result turnaround time. ... Triglycerides powder reagent provides a long ...
... single liquid stable reagent offers the ... liquid stability to help maximize laboratory ... quick result turnaround time. The patented ... provides a long shelf life that ...
... Infinity Creatinine single liquid stable reagent ... of single liquid stability to help ... and provide quick result turnaround time. ... Creatinine reagent provides a long shelf ...
... Amylase powder reagent once reconstituted offers ... single liquid stability to help maximize ... provide quick result turnaround time. The ... powder reagent provides a long shelf ...
Medicine Products: