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Arena Pharmaceuticals Reports Positive, Highly Significant BLOSSOM Trial Results for Weight Management; NDA Submission on Track for December
Date:9/17/2009

st at least 10% of their body weight compared to 9.7% for placebo (p<0.0001);

Lorcaserin 10 mg Once Daily

  • 40.2% of patients treated with 10 mg of lorcaserin dosed once daily lost at least 5% of their body weight (p<0.0001); and
  • 17.4% of patients treated with 10 mg of lorcaserin dosed once daily lost at least 10% of their body weight (p<0.0001).

Patients who took lorcaserin 10 mg twice daily achieved an average weight loss of 5.9% of their body weight, compared to 2.8% for placebo (p<0.0001). Similarly, patients who took lorcaserin 10 mg once daily achieved an average weight loss of 4.8% of their body weight (p<0.0001).

BLOSSOM Confirms BLOOM

In BLOSSOM, as in BLOOM, lorcaserin's excellent tolerability allowed patients to begin treatment at the full dose immediately, without a titration period, and achieve rapid weight loss. As in BLOOM, significant weight loss compared to placebo was shown at the first trial visit, two weeks following randomization.

The efficacy for the BLOOM and BLOSSOM trials after one year of treatment are summarized in the table below.

                               BLOOM                   BLOSSOM
                               -----                   -------


                       10 mg BID*  Placebo  10 mg BID*  10 mg QD*  Placebo
                       ----------  -------  ----------  ---------  -------
    >/=5% weight loss
     (Per protocol)       66.4%     32.1%     63.2%       53.1%     34.9%
    ---------------       ----      ----      ----        ----      ----
    >/=5% weight loss
     (ITT-LOCF)           47.5%     20.3%     47.2%       40.2%     25.0%
    ---------------       ----      ----      ----        ----      ----
    >/=10% weight loss
     (Per protocol) 
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SOURCE Arena Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

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