Navigation Links
Arena Pharmaceuticals Presented Positive Phase 2a Clinical Trial Results of APD125 for the Treatment of Insomnia at 22nd Annual Meeting of the Associated Professional Sleep Societies
Date:6/12/2008

with primary insomnia. The trial evaluated standard PSG measurements of sleep, such as WASO, WTDS, number of awakenings, number of arousals, total sleep time and latency to persistent sleep, and enrolled a total of 173 male and female patients, ages 18-64, in 24 sleep research centers in the United States. To qualify for enrollment, patients were required to have paired screening PSGs that demonstrated an average WASO greater than or equal to 60 minutes, with neither PSG less than 45 minutes.

Every patient received both active doses of APD125 (10 mg and 40 mg) and placebo in random order for one week, separated by a seven to nine day washout period between each dosing period. Efficacy was measured objectively by averaging PSG values for N 1/2 and for N 6/7, versus baseline values obtained by averaging results from the screening PSGs.

About APD125

Discovered by Arena, APD125 is a novel and oral selective inverse agonist of the 5-HT2A serotonin receptor. The vast majority of approved drugs for insomnia work by activating the GABA-A receptor complex in the brain, causing a general suppressive effect on the central nervous system, or CNS. These GABAergic drugs are generally associated with CNS side effects, including a sensation of dullness and lethargy upon awakening, often referred to as the "hangover effect." Other potential problems associated with the GABAergic drugs include the risk of developing tolerance and drug dependency in at-risk populations. In addition, GABAergic drugs are scheduled controlled substances by the Drug Enforcement Administration due to their potential for abuse.

APD125 acts through a different mechanism than currently marketed insomnia drugs. Arena believes that by selectively targeting the 5-HT2A receptor, APD125 blocks one of several CNS activating pathways rather than initiating a general CNS suppressive effect. Because of the different mechanism of action, APD125 may not have the side effects or abuse potenti
'/>"/>

SOURCE Arena Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Arena Pharmaceuticals, Inc. Announces Initiation of Phase 1 Clinical Trial of Drug Candidate Under Partnership with Taisho Pharmaceutical Co., Ltd.
2. Arena Pharmaceuticals Initiates Phase 2b Clinical Trial of APD125 for the Treatment of Insomnia
3. Arena Pharmaceuticals Announces Positive Phase 1a Clinical Trial Results of APD791 for the Treatment of Arterial Thrombosis and Initiates Phase 1b Clinical Trial
4. Arena Pharmaceuticals Announces APD668 Initial Clinical Study Results Suggest Glucose-Dependent Insulinotropic Receptors May Improve Glucose Control in Patients With Type 2 Diabetes
5. Arena Pharmaceuticals Announces Positive Phase 2 Clinical Trial Results of APD125 for the Treatment of Insomnia
6. Arena Pharmaceuticals to Present at Four Upcoming Investor Conferences
7. Morria Biopharmaceuticals Plc Announces Regulatory Approval to Commence Phase II Clinical Study of MRX-4 in Allergic Rhinitis
8. Transcept Pharmaceuticals Announces Intent to Submit New Drug Application for Intermezzo(R) in Third Quarter 2008
9. Semafore Pharmaceuticals Reports Positive Interim Results from a Phase I Study of SF1126, a Targeted Pan-PI3K Inhibitor, in Patients with Advanced Solid Tumors
10. Sunesis Pharmaceuticals Focuses Resources on Development of Voreloxin (Formerly SNS-595)
11. Celator(R) Pharmaceuticals Announces Positive Phase 2 Results for CPX-1 in Treatment of Colorectal Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... 2014 Research and Markets  has announced ... Market Research Report 2014" report to their offering. ... Report 2014 presents comprehensive data on paracetamol (acetaminophen) markets ... Asia , North America ... (acetaminophen) description, covers its application areas and related patterns. ...
(Date:9/15/2014)... , Sept. 15, 2014 Sysmex America, ... information systems technology, announced today an amended distributorship ... is for Sysmex reagents, controls and instruments including ... ™ , Sysmex XP-300™, XT-Series and XN-Series ... is effective immediately and continues until August 31, ...
(Date:9/15/2014)... , Sept. 15, 2014  Mariel Therapeutics, Inc., ... Protein-7 and its application in Osteoarthritis (OA) and Chronic ... experts to its newly formed scientific advisory board. The ... and scientific resource to the company as it continues ... "We are honored to have such leading experts in ...
Breaking Medicine Technology:Paracetamol (Acetaminophen) (CAS 103-90-2) Market Research Report 2014 2Paracetamol (Acetaminophen) (CAS 103-90-2) Market Research Report 2014 3Sysmex America, Inc. Renews LABSCO Distributorship 2Sysmex America, Inc. Renews LABSCO Distributorship 3Mariel Therapeutics Appoints World Leading Experts to Inaugural Scientific Advisory Board 2Mariel Therapeutics Appoints World Leading Experts to Inaugural Scientific Advisory Board 3Mariel Therapeutics Appoints World Leading Experts to Inaugural Scientific Advisory Board 4
... Mass., Aug. 25, 2011 Caliper Life Sciences, ... that its presentation at the Stifel Nicolaus Healthcare ... at 11:30 a.m. EDT.  Kevin Hrusovsky, President and ... on the company,s business. The live webcast can ...
... Aug. 25, 2011 PDI, Inc. (Nasdaq: ... promotional and commercialization services to health care companies, today ... Top 10 pharmaceutical company has been renewed for an ... PDI,s Shared Sales team beginning in September 2011 through ...
Cached Medicine Technology:PDI Announces Renewal of Engagement for 7th Consecutive Season 2
(Date:9/16/2014)... (PRWEB) September 16, 2014 On September ... Danielle Strassle at the 2014 Buffalo Bills Alumni Foundation ... NY. , Bills legend and NFL Hall-of-Famer Joe ... the foundation in honoring Strassle for her dedication in ... goals and inspire others in her community to do ...
(Date:9/16/2014)... Austin, Texas (PRWEB) September 16, 2014 ... now be offering $0 shipping on all kettlebell purchases ... it easy for customers to get started with this ... of the Crossfit movement. The online store carries a ... education and free weekly workouts guides. , ...
(Date:9/16/2014)... 16, 2014 Antioch University has introduced ... in Clinical Mental Health Counseling from Antioch University ... of programs offered through Antioch’s online campus. The program ... 2015. , "Antioch University New England’s MA in Clinical ... field and a track record of preparing graduates for ...
(Date:9/16/2014)... 16, 2014 QuickMedical, a national ... supplies and a veteran-owned small business has officially ... Jant Pharmacal Corporation, Nipro Medical, and CP Medical ... its customers the best, most affordable medical equipment ... and in an effort to reach new medical ...
(Date:9/16/2014)... VA (PRWEB) September 16, 2014 The ... of Virginia this fall. Reflecting on what it means ... Expanding Community Vision investigates unique and thought-provoking topics. , ... to be inspired to look at their world differently. ... and set the stage for truly enlightening dialogue,” says ...
Breaking Medicine News(10 mins):Health News:The HearStrong Foundation and the Buffalo Bills Alumni Foundation Celebrated HearStrong Champion During 2014 Alumni Weekend 2Health News:Join the Kettlebell Movement - Kettlebell Kings Announces $0 Shipping on all Orders 2Health News:Antioch University Launches Online Master’s Degree Program in Clinical Mental Health Counseling 2Health News:Expanding Community Vision at the Science Museum of Virginia 2
... perfect example of a corporation that chose to, protect their ... piracy., -- Safwat Fahmy, SafeMedia Founder and ... ... Fla., April 8, 2008 Adamis Laboratories and,SafeMedia announced today that ...
... Corporation,(TSX:HAE), a specialty bio-therapeutics company developing high-value human,therapeutic proteins for commercialization, will hold ... Wednesday, April 9, 2008, Time: ... The National Club ... Toronto, Ontario ...
... Throw down your,mop and broom! Spring cleaning the house ... your body. Daily exposure to thousands of,toxins in the ... toxic load in the body that may result in ... ), "Ideally, you should cleanse with the seasons ...
... SEATTLE, April 8, 2008 The appearance of a ... a tune-up before other more serious,illnesses emerge, according to ... for Bastyr University., Worldwide, between 80% and 90% ... Simplex Virus or HSV-1), according to Dr. Sherman, who,is ...
... safety incidents cost the federal Medicare program $8.8 ... during 2004 through 2006, according to HealthGrades, fifth ... analysis of 41 million Medicare patient records found ... average, a 43 percent lower chance of experiencing ...
... EDT, WALTHAM, Mass., April 7, 2008 Repligen,Corporation ... President and,Chief Executive Officer, Walter C. Herlihy, Ph.D., will ... 2008 at 9:00 a.m. EDT, to provide,an update on ... by Thomson/CCBN and can be accessed via,Repligen,s website at ...
Cached Medicine News:Health News:Leading Life Sciences Company Installs SafeMedia's Network Security Management Appliance to Prevent Illegal Peer to Peer (P2P) File Sharing 2Health News:Media Invitation - Annual General and Special Meeting of Shareholders of Haemacure 2Health News:Spring Clean Your Body for the Perfect Cleanse 2Health News:A Cold Sore Is Often A Warning Sign of Deeper Health Issues, Expert Says 2Health News:Medical errors cost US $8.8B, result in 238,337 potentially preventable deaths: HealthGrades study 2Health News:Medical errors cost US $8.8B, result in 238,337 potentially preventable deaths: HealthGrades study 3Health News:Medical errors cost US $8.8B, result in 238,337 potentially preventable deaths: HealthGrades study 4Health News:Repligen Announces Conference Call to Update Orencia(R) Lawsuit 2Health News:Repligen Announces Conference Call to Update Orencia(R) Lawsuit 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: