Navigation Links
Arena Pharmaceuticals Completes Phase 1b Clinical Trial Evaluating APD811 for Pulmonary Arterial Hypertension
Date:8/28/2013

SAN DIEGO, Aug. 28, 2013 /PRNewswire/ -- Arena Pharmaceuticals, Inc. (NASDAQ: ARNA) today announced the completion of a Phase 1b clinical trial for APD811, an investigational oral prostacyclin (IP) receptor agonist intended for the treatment of pulmonary arterial hypertension (PAH). The company plans to initiate a Phase 2 clinical trial for APD811 in the first quarter of 2014.

"Arena's internal GPCR-focused efforts led to the discovery of this novel drug candidate," said William R. Shanahan, M.D., Arena's Senior Vice President and Chief Medical Officer. "We believe APD811 is a promising new chemical entity that could improve current patient care by providing an oral option for IP-targeted therapy. Based on the encouraging Phase 1 results, we look forward to initiating the Phase 2 program early next year."

This randomized, double-blind and placebo-controlled Phase 1b clinical trial evaluated the safety, tolerability and pharmacokinetics of multiple-ascending doses of APD811. Arena previously evaluated single-ascending doses of APD811 in a Phase 1a clinical trial.

In the Phase 1b clinical trial, 40 healthy volunteers received APD811 and 15 received placebo, and the safety profile of APD811 was characteristic of IP receptor agonists. No serious adverse events were observed, and the most frequent treatment-emergent adverse events were headache, nausea and jaw pain. The results of the Phase 1 program led to the decision to proceed with Phase 2 development of APD811, which will include further exploration of dosing regimens in PAH patients. 

About Pulmonary Arterial Hypertension (PAH)PAH is a progressive, life-threatening disorder characterized by increased pressure in the arteries that carry blood from the heart to the lungs. The increased pressure strains the heart, which can limit physical act
'/>"/>

SOURCE Arena Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Arena Pharmaceuticals Provides Corporate Update and Reports Second Quarter 2013 Financial Results
2. Arena Pharmaceuticals to Host Corporate Update and Financial Results Conference Call and Webcast on Thursday, August 1
3. Arena Pharmaceuticals to Present at the 2013 Wells Fargo Securities Healthcare Conference
4. Former Semi-Pro Arena Football Player Bridged to Heart Transplant with the SynCardia Total Artificial Heart
5. Arena Pharmaceuticals to Present at the Bank of America Merrill Lynch 2013 Health Care Conference
6. BIOCOM Applauds Arena Pharmaceuticals Commitment to Innovation, Contributions to Southern California Life Science Community
7. Carena Launches 24/7 Virtual Care Delivery Service for Hospital Systems and Primary Care Clinics
8. Arena Pharmaceuticals Provides Corporate Update and Reports First Quarter 2013 Financial Results
9. Arena Pharmaceuticals to Host Corporate Update and Financial Results Conference Call and Webcast on Thursday, May 2
10. Arena Pharmaceuticals Initiates Phase 1 Clinical Trial of APD334 for Autoimmune Diseases
11. Arena Pharmaceuticals Provides Corporate Update and Reviews Fourth Quarter and Full Year 2012 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... , July 11, 2014 The ... are evolving across industry sectors to better identify ... better ways to engage with and understand consumers, ... themselves and make critical purchasing decisions. ... Best Practices, LLC, one area where organizations can ...
(Date:7/11/2014)... 2014 Research and Markets has ... Medical X-ray Film Industry Report 2014" report to ... Global And Chinese Medical X-Ray Film Industry ... the current state of the Global medical X-ray film ... The report provides a basic overview of the industry ...
(Date:7/11/2014)... 2014 Research and Markets  has announced ... 2014-2018" report to their offering. ... is a hollow needle commonly used with a syringe ... extract fluids from it. A hypodermic needle is used ... that cannot be ingested. Hypodermic needles are broadly classified ...
Breaking Medicine Technology:New Technologies Transforming Consumer Marketing Research Playbook 2Global and Chinese Medical X-ray Film Industry Report 2014 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 3
... Pa., Aug. 31, 2011 Unilife Corporation ("Unilife" ... today announced that its Chief Operating Officer, Dr. Ramin Mojdeh, ... common stock. This investment closely follows Dr. Mojdeh,s initial open ... March 2011, six weeks after he joined the Company. ...
... 31, 2011 Accuray Incorporated ... radiation oncology company, announced today the launch of ... organization for CyberKnife® Robotic Radiosurgery System and TomoTherapy® Radiation ... worldwide clinical and technical collaboration. AERO,s ...
Cached Medicine Technology:Unilife COO to Again Purchase More Than $250,000 in Company Shares 2Unilife COO to Again Purchase More Than $250,000 in Company Shares 3Accuray Launches New Organization for CyberKnife® and TomoTherapy® System Users 2Accuray Launches New Organization for CyberKnife® and TomoTherapy® System Users 3Accuray Launches New Organization for CyberKnife® and TomoTherapy® System Users 4
(Date:7/11/2014)... Biostimulants are widely applied in turf and ornamentals. They ... help turf and ornamentals in absorption of water, nutrient ... flowers appear healthy and strong as a result of ... last few years. The most dominating region in biostimulants ... 40% share in 2013, and is estimated to grow ...
(Date:7/11/2014)... PROVIDENCE, R.I. -- Researchers from The Miriam ... under age 65 have significantly higher rates of ... with mobility impairments were less likely to attempt ... quit-smoking treatments may not be sufficient for this ... online in advance of print in the ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 The ... five years to 2014 on the heels of fresh ... prompted farmers to dedicate a larger share of their ... More specifically, the regulations required the mixing of 5.0% ... biofuel production in the United States created a key ...
(Date:7/11/2014)... Prostate cancer patients are more likely to be diagnosed ... sooner if they also have depression, a new study ... American men who were diagnosed with localized prostate cancer ... Nearly 1,900 of the patients had been diagnosed with ... was discovered. "Men with intermediate- or high-risk prostate ...
(Date:7/11/2014)... 11, 2014 Riverside Health System became the ... in Virginia in late 2012 and now, in partnership with ... residents throughout the Williamsburg and Newport News region. , Also ... and benefits to independent older adults who wish to remain ... safety net of continuing care services as well as control ...
Breaking Medicine News(10 mins):Health News:Biostimulants Market in Turf and Ornamentals is Expected to Reach $ 3.8 Billion by 2018 - New Report by MicroMarket Monitor 2Health News:Biostimulants Market in Turf and Ornamentals is Expected to Reach $ 3.8 Billion by 2018 - New Report by MicroMarket Monitor 3Health News:Miriam Hospital study examines smoking prevalence 2Health News:Corn Farming in Canada Industry Market Research Report Now Available From IBISWorld 2Health News:Corn Farming in Canada Industry Market Research Report Now Available From IBISWorld 3Health News:Depression May Make It Harder to Beat Prostate Cancer 2Health News:Riverside and Williamsburg Landing Partner to Offer First of Its Kind Service to Virginians Who Want to Age in Place 2Health News:Riverside and Williamsburg Landing Partner to Offer First of Its Kind Service to Virginians Who Want to Age in Place 3Health News:Riverside and Williamsburg Landing Partner to Offer First of Its Kind Service to Virginians Who Want to Age in Place 4
... Lube Leader Reaches Halfway Point in Campaign to Support American ... Heart Association,s Go Red For Women(TM) Movement, HOUSTON, Feb. ... to its goal of raising $1 million for the,American Heart ... Heart Month are almost in the rear-view mirror, Jiffy,Lube wants ...
... according to a study of more than 77,000 vitamin ... risk of developing it. , Our study of supplemental ... show any evidence for a decreased risk of lung ... of the University of Washington, in Seattle. Indeed, increasing ...
... and a decision algorithm, rather than standard hospital protocols, ... patients with severe sepsis or septic shock can reduce ... costs all without adverse effects on patients, according to ... possible to customize antibiotic treatment duration in patients with ...
... UT Southwestern Medical Center have determined that the level, or ... children with sickle cell anemia who are at an increased ... have also found that a published method used to predict ... , Stroke is a serious but increasingly preventable complication of ...
... affected by ... rare diseases, NEW YORK, Feb. ... Day will be launched on Friday 29,February...because it,s a rare day that ... Shire plc at:, http://media.medialink.com/WebNR.aspx?story=34701 ), Collectively, rare diseases aren,t ...
... to Reliance on Spill-Proof,Cups, GLENDALE, Calif., Feb. 28 ... Dental Hygienists, Association,(CDHA) today urged parents and caregivers to ... "We all know that sippy cups are a godsend ... "But they need to be used wisely and,properly in ...
Cached Medicine News:Health News:Jiffy Lube(R) Continues Drive Against Heart Disease with Maintenance Partners for Life Campaign 2Health News:Jiffy Lube(R) Continues Drive Against Heart Disease with Maintenance Partners for Life Campaign 3Health News:Jiffy Lube(R) Continues Drive Against Heart Disease with Maintenance Partners for Life Campaign 4Health News:Certain vitamin supplements may increase lung cancer risk, especially in smokers 2Health News:Customized treatments for sepsis lower treatment time and reduce length of ICU stays 2Health News:UT Southwestern researchers investigate predictors for sickle-cell-anemia complications 2Health News:VIDEO from Medialink and Shire plc: Rare Diseases Must Be Top of the Health Agenda 2Health News:VIDEO from Medialink and Shire plc: Rare Diseases Must Be Top of the Health Agenda 3Health News:California Dental Hygienists Offer Tips for Safe Sippy Cup Use 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: