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Arena Pharmaceuticals Announces Third Quarter 2010 Financial Results and Reviews Recent Developments
Date:11/9/2010

er were presented at Obesity 2010, the 28th Annual Scientific Meeting of The Obesity Society. The data presented showed that lorcaserin reduces energy intake and appetite, and causes weight loss without stimulating energy expenditure.
  • The FDA completed the Pre-Approval Inspection of Arena's drug product manufacturing facility in Switzerland and classified the inspection as No Action Indicated.
  • Results from Arena's two-year, pivotal Phase 3 BLOOM (Behavioral modification and Lorcaserin for Overweight and Obesity Management) trial were published in the July 15, 2010, issue of the New England Journal of Medicine. The data presented in the article show that lorcaserin used in conjunction with behavioral modification caused significantly greater weight loss and improved maintenance of weight loss compared to placebo. The data also indicated that lorcaserin improved values for biomarkers that may be predictive of future cardiovascular events, including lipid levels, insulin resistance, levels of inflammatory markers and blood pressure.
  • Arena's wholly owned subsidiary, Arena Pharmaceuticals GmbH, entered into a marketing and supply agreement with Eisai Inc. for the commercialization of lorcaserin in the United States following FDA approval of the NDA for lorcaserin. Under the terms of the agreement, Arena received a non-refundable, upfront payment of $50.0 million from Eisai.

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  • Announced that following the completion of a Phase 1 clinical trial program for APD597, Ortho-McNeil-Janssen Pharmaceuticals, Inc., decided not to advance APD597 and notified Arena that it is terminating their collaboration, effective December 28, 2010. APD597 is a GPR119 agonist intended for the treatment of type 2 diabetes, which, along with other compounds and intellectual property, will revert to Arena upon termination of the collaboration. The Phase 1 program provided evidence for incretin stimulation (GLP-1, GIP and PYY) and reducti
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    1. Arena Pharmaceuticals Provides Update on GPR119 Portfolio for Type 2 Diabetes
    2. Endologix Announces Publication of Clinical Trial Results Supporting Anatomical Fixation with a Suprarenal Aortic Extension
    3. Arena and Eisai Announce Upcoming Lorcaserin Presentations at Obesity 2010
    4. Arena and Eisai Provide Update on Lorcaserin FDA Advisory Committee Meeting
    5. Arena Pharmaceuticals to Host Conference Call and Webcast Following Lorcaserin FDA Advisory Committee Meeting
    6. Arena Pharmaceuticals Submits New Drug Application to FDA for Lorcaserin for Weight Management
    7. Published Data Demonstrate Arena Pharmaceuticals Lorcaserin Has Low Abuse Potential
    8. Arena Pharmaceuticals Announces Third Quarter 2009 Financial Results and Recent Developments
    9. Arena Pharmaceuticals to Host Business and Financial Update Conference Call and Webcast on Tuesday, November 10, 2009
    10. Arena Pharmaceuticals Lorcaserin to be Featured in Multiple Presentations at Obesity 2009
    11. Arena Pharmaceuticals Reports Positive, Highly Significant BLOSSOM Trial Results for Weight Management; NDA Submission on Track for December
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