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Arena Pharmaceuticals Announces Positive Phase 1b Clinical Trial Results of APD791 for the Treatment of Arterial Thrombosis
Date:7/9/2008

osis with a novel mechanism that may provide advantages over currently available therapies," said William R. Shanahan, M.D., Arena's Vice President and Chief Medical Officer. "We will review and evaluate the results with our consultants to develop the best approach to advance APD791 into Phase 2 clinical trials. We are also actively exploring partnership opportunities for this candidate."

"These positive results also demonstrate the utility of our focus on G protein-coupled receptor (GPCR) drug research and the general approach we take toward developing innovative treatments for serious medical conditions. Applying our GPCR focus and expertise, we've developed a pipeline of seven novel development stage drug candidates, five of which are in the clinic," stated Dominic P. Behan, Ph.D., Arena's Senior Vice President and Chief Scientific Officer.

About APD791

APD791 is a novel, oral and selective inverse agonist of the 5-HT2A serotonin receptor. Serotonin activation of the 5-HT2A receptor on platelets and vascular smooth muscle is thought to play an important role in events leading to thrombosis, and elevated serotonin levels have been associated with increased cardiovascular risk. Normally, when a platelet is activated by one of a number of factors, such as thrombin or collagen, the platelet releases serotonin, which, based on preclinical studies, promotes platelet aggregation, vasoconstriction and intimal hyperplasia. By blocking activation of the 5-HT2A receptor on platelets and other cardiovascular tissues, APD791 may curb these serotonin-mediated effects in the clinical setting, thereby reducing or preventing thrombosis. Furthermore, based upon preclinical studies, Arena believes that APD791, by preventing only the amplification of platelet aggregation induced by primary aggregators such as ADP and collagen, may allow sufficient platelet aggregation at therapeutic doses to avoid the bleeding risk associated with other anti-platelet agents whil
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SOURCE Arena Pharmaceuticals, Inc.
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