Navigation Links
Arena Pharmaceuticals Announces Positive Phase 1b Clinical Trial Results of APD791 for the Treatment of Arterial Thrombosis
Date:7/9/2008

SAN DIEGO, July 9 /PRNewswire-FirstCall/ -- Arena Pharmaceuticals, Inc. (Nasdaq: ARNA) today announced positive results from a multiple-ascending dose Phase 1b clinical trial of APD791 to evaluate the compound's safety, pharmacokinetics and pharmacodynamics. APD791 is Arena's internally discovered oral drug candidate intended for the treatment of arterial thrombosis and other related conditions.

The Phase 1b trial was a randomized, double-blind, placebo-controlled, multiple-ascending dose trial in 50 healthy adult male and female volunteers. Daily doses ranged from 15 mg to 240 mg and were generally well tolerated. The most frequently reported adverse event was headache, which was more common in the placebo group than in any APD791 dose group. None of the adverse events occurred in a dose-related fashion with the exception of epistaxis (nose bleed), which occurred in two volunteers in the 240 mg group, a dose outside the anticipated therapeutic range.

In addition to evaluating APD791's safety and tolerability profile, the trial evaluated the pharmacokinetics and pharmacodynamics of multiple oral doses of APD791 over a period of one week. APD791 was rapidly absorbed and exposures were related to dose. Dose-dependent inhibition of serotonin-mediated amplification of platelet aggregation was demonstrated starting at the 15 mg dose and will permit the identification of exposure ranges that produce minimal, moderate and near-complete inhibition of serotonin-mediated platelet aggregation. These results further support APD791's novel mechanism of action and preclinical and Phase 1a clinical trial data.

"These results support APD791's potential to treat a variety of central and peripheral conditions related to arterial thromb
'/>"/>

SOURCE Arena Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Arena Pharmaceuticals Presented Positive Phase 2a Clinical Trial Results of APD125 for the Treatment of Insomnia at 22nd Annual Meeting of the Associated Professional Sleep Societies
2. Arena Pharmaceuticals, Inc. Announces Initiation of Phase 1 Clinical Trial of Drug Candidate Under Partnership with Taisho Pharmaceutical Co., Ltd.
3. Arena Pharmaceuticals Initiates Phase 2b Clinical Trial of APD125 for the Treatment of Insomnia
4. Arena Pharmaceuticals Announces Positive Phase 1a Clinical Trial Results of APD791 for the Treatment of Arterial Thrombosis and Initiates Phase 1b Clinical Trial
5. Arena Pharmaceuticals Announces APD668 Initial Clinical Study Results Suggest Glucose-Dependent Insulinotropic Receptors May Improve Glucose Control in Patients With Type 2 Diabetes
6. Arena Pharmaceuticals Announces Positive Phase 2 Clinical Trial Results of APD125 for the Treatment of Insomnia
7. Arena Pharmaceuticals to Present at Four Upcoming Investor Conferences
8. Anadys Pharmaceuticals Resumes Clinical Investigation of TLR7 Mechanism in HCV
9. University of Rochester Researcher Named Millennium Pharmaceuticals Career Development Scholar of The Leukemia & Lymphoma Society
10. Peregrine Pharmaceuticals Reports Positive Early Results in Phase II Study of Bavituximab in Breast Cancer
11. Isis Pharmaceuticals Conference Call Notice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... Partnership to Fight Chronic Disease (PFCD) released a public opinion poll ... new study analyzing the impact of increased cost sharing on patient ... to educate policy makers and the public on the costs of ... how the Iowa healthcare exchange could be ...
(Date:1/23/2015)... 2015  Northwest Biotherapeutics, Inc. (NASDAQ: NWBO )("NW Bio"), ... operable and inoperable solid tumor cancers, announced today that CEO ... Annual Phacilitate Immunotherapy Forum in Washington D.C. ... take place on January 26 at 10:30 a.m. EST at ...
(Date:1/23/2015)... More than a third of reproductive-aged women enrolled in Medicaid, ... filled a prescription for an opioid pain medication each year ... and Mortality Weekly Report (MMWR). Opioids are ... severe pain.  They are also found in some prescription cough ...
Breaking Medicine Technology:New research shows Iowa health exchange would benefit from improvements 2New research shows Iowa health exchange would benefit from improvements 3NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 2NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 3Opioid painkillers widely prescribed among reproductive age women 2Opioid painkillers widely prescribed among reproductive age women 3
... Australia, June 21, 2007-At a time when Australian,scientists are ... an Australian biotech company is leading the world,in the ... Apollo CEO John Priest said the company's human proteins ... develop into specific,cell types such as heart, nerve and ...
... - Senator Obama today,released the following statement in response ... funding for stem cell research once again, the,President is ... have the time to keep waiting for the cure ... stem cells hold does not come,from any particular ideology, ...
Cached Medicine Technology:Apollo's human proteins boost stem cell research 2
(Date:1/22/2015)... The U.S. Pharmacopeial Convention is pleased to announce that ... at North Carolina State’s College of Veterinary Medicine has ... for Distinguished Volunteer Service—the organization’s highest award. , ... volunteer experts to direct its work to improve the ...
(Date:1/22/2015)... Woodloch Pines, an all-inclusive family resort located in ... number one best large hotel for families in the United ... annual Travelers’ Choice Awards. , TripAdvisor represents the world’s ... to millions of unbiased and honest traveler reviews. The best ...
(Date:1/22/2015)... 2015 The Incredible Bulk is a revolutionary ... increase lean muscle by up to 30lbs in less than ... of HealthyandFitZone.com’s Stan Stevenson, prompting an investigative review. , “Our ... step-by-step, scientific diet formula that allows the body to pack ...
(Date:1/22/2015)... New York (PRWEB) January 22, 2015 The ... ) in the U.S. District Court, Southern District of West ... Bard, Inc. in that proceeding’s first bellwether trial. In an ... for a new trial after finding that C.R. Bard had ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Autocarinsurancebest.com has released ... purchasing a commercial auto insurance policy . , Auto ... their vehicles. It is no longer necessary to call an ... are now available online on a single website: http://autocarinsurancebest.com/ ...
Breaking Medicine News(10 mins):Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 2Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 3Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 4Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 3Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:Commercial Auto Insurance Provides Several Important Features! 2
... drugs to check vascular proliferation that is hallmark of ... -- Researchers have pinpointed a biological pathway that may ... cases of blindness in the United States. , Though ... new therapeutic target for such ophthalmic diseases as age-related ...
... date of March 24, 2008 ... approves Hillenbrand Industries name change to Hill-Rom Holdings, Inc., at separation; recently created ... separation, -- "Ex-Distribution" and "When Issued" Trading expected to commence March ... ...
... Johnson Vision Care and U.S. Soccer Federation team up to ... U.S. athletes a performance edge with better vision, JACKSONVILLE, ... and marketer of ACUVUE(R) Brand Contact Lenses,today announced it is ... governing body for the sport of soccer in the United,States., ...
... March 17 Tropical Traditions,announced today that they added ... is believed to be the first product of its ... the water inside of coconuts is a,cottage industry in ... inside of coconuts is highly valued due to its ...
... Improves Senior Citizens Cognitive ... ... accepted for,publication in the Journal of Psychopharmacology, demonstrates,Pycnogenol(R), (pic-noj-en-all), an antioxidant ... the memory of senior citizens.,The study results revealed Pycnogenol(R) improved both ...
... - Month-12 Independent Echocardiographic Data Safety Monitoring ... Safety Profile -, SAN DIEGO, March ... ) announced today that following a planned ... Board (EDSMB) it is,continuing BLOOM (Behavioral modification ...
Cached Medicine News:Health News:Study Finds Potential Cause of Age-Related Macular Degeneration 2Health News:Study Finds Potential Cause of Age-Related Macular Degeneration 3Health News:Hillenbrand Industries Announces Formal Board Approval of Separation by Means of Share Distribution and Details for Completion 2Health News:Hillenbrand Industries Announces Formal Board Approval of Separation by Means of Share Distribution and Details for Completion 3Health News:Hillenbrand Industries Announces Formal Board Approval of Separation by Means of Share Distribution and Details for Completion 4Health News:U.S. Soccer Team Putting Vision in Focus for the Beijing 2008 Olympic Games 2Health News:U.S. Soccer Team Putting Vision in Focus for the Beijing 2008 Olympic Games 3Health News:Tropical Traditions Announces New Organic Raw Coconut Water Vinegar 2Health News:New Study: Pycnogenol(R) Improves Memory in Elderly 2Health News:New Study: Pycnogenol(R) Improves Memory in Elderly 3Health News:Arena Pharmaceuticals' Lorcaserin for Obesity Passes Major Safety Milestone 2Health News:Arena Pharmaceuticals' Lorcaserin for Obesity Passes Major Safety Milestone 3Health News:Arena Pharmaceuticals' Lorcaserin for Obesity Passes Major Safety Milestone 4Health News:Arena Pharmaceuticals' Lorcaserin for Obesity Passes Major Safety Milestone 5Health News:Arena Pharmaceuticals' Lorcaserin for Obesity Passes Major Safety Milestone 6
... The new "Innovation Joint Technology" elbow brace ... medical specialists to help re-establish pain free ... Brace has been engineered to provide the ... dynamic rotation forces. Treatment use includes Wrist ...
Designed to provide comfortable immobilization of the elbow...
... Orthosis decreases the effects of flexion synergy ... forearm, wrist simultaneously. First, apply elbow component ... available passive ROM. Next, attach pronation/supination bar ... to the bar. Use included Allen wrench ...
... The Elbow Cryo/Cuff combines the therapeutic ... and swelling, and cold to minimize pain. ... fit the elbow providing maximum cryotherapy. The ... size in addition to a pediatric size.,All ...
Medicine Products: