Navigation Links
Ardea Biosciences Reports Additional Positive Phase 2a Results for Lead HIV Candidate, RDEA806, Demonstrating Up to 1.9 Log Reduction in Plasma Viral Load with Once-Daily Dosing
Date:6/25/2008

p>

About RDEA806

RDEA806 is a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) for the potential treatment of HIV infection. Based on preclinical and clinical studies to-date, Ardea believes that RDEA806 may have important competitive advantages. These include the potential for potent antiviral activity against a wide range of HIV viral isolates, including those that are resistant to efavirenz (Sustiva(R)) and other currently available NNRTIs; a high genetic barrier to resistance; no reproductive toxicity based on animal studies; the potential to be administered in a patient-friendly, oral dosing regimen; limited pharmacokinetic interactions with other drugs; and the ability to be co-formulated with other HIV antiviral drugs.

About Ardea Biosciences

Ardea Biosciences, Inc., of San Diego, California, is a biotechnology company focused on the discovery and development of small-molecule therapeutics for the treatment of HIV, cancer and inflammatory diseases, including gout. We have four drug candidates in clinical trials and others in preclinical development and discovery. Our most advanced development candidate is RDEA806, a non-nucleoside reverse transcriptase inhibitor (NNRTI), which has completed a Phase 2a study for the treatment of HIV. We have evaluated our second-generation NNRTI for the treatment of HIV, RDEA427, in a human micro-dose pharmacokinetic study and have selected it as a development candidate. RDEA594, our lead development candidate for the treatment of gout, is in preclinical development and is believed to be an inhibitor of the URAT1 transporter in the kidney, which is responsible for regulation of uric acid levels. We are evaluating our lead MEK inhibitor, RDEA119, in a Phase 1 study in advanced cancer patients, as well as in a Phase 1 study in normal healthy volunteers as a precursor to trials in patients with inflammatory diseases. Lastly, we have evaluated our second- generation MEK inhibitor for the treatmen
'/>"/>

SOURCE Ardea Biosciences, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Ardea Biosciences, Inc. Announces Completion of Phase 1 Clinical Trials of Novel Investigational HIV Drug RDEA806
2. Ardea Biosciences, Inc. Presents Results of Phase 1 Studies of RDEA806, a Novel NNRTI for HIV, at 47th ICAAC
3. Ardea Biosciences Lead MEK Inhibitor, RDEA119, to Enter Human Clinical Trials in Advanced Cancer Patients
4. Ardea Biosciences, Inc. Announces New Clinical Development Program Directed Toward the Treatment of Gout
5. Ardea Biosciences Presents Preclinical Data Demonstrating Favorable Resistance Profiles for Non-Nucleoside Reverse Transcriptase Inhibitors for the Treatment of Human Immunodeficiency Virus
6. Ardea Biosciences Reports Positive Phase 2a Results for Lead HIV Candidate, RDEA806, Demonstrating up to 2.0 Log Reduction in Plasma Viral Load
7. Ardea Biosciences Presents Data Demonstrating Favorable Pharmacokinetics and Efficacy for Mitogen-Activated ERK Kinase (MEK) Inhibitors
8. Ardea Biosciences Appoints John W. Beck Chief Financial Officer, Announces Clinical Development Progress and Reports First Quarter 2008 Financial Results
9. Ardea Biosciences Identifies Lead Development Candidate for Gout, RDEA594
10. Ardea Biosciences Presents Preclinical Data on RDEA119 Demonstrating Favorable Anti-Inflammatory Profile for Potential Use in Ulcerative Colitis
11. Ardea Announces Progress with HIV Non-Nucleoside Reverse Transcriptase Inhibitor Program
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... 30, 2015 Velos, Inc., the pioneering software ... grow and add customers who receive Clinical and Translational ... CTSAs awarded by the National Institutes of Health currently ... is among the largest such market shares in its ... CTSA community keeps growing as a result of our ...
(Date:6/30/2015)... , June 30, 2015   Millar, Inc. ... technology, today announced the 2016 retirement of Craig ... Directors, after 12 years of service to the Company. ... named two senior members of the Executive Management team ... Tim Daugherty , currently Director of Sales and ...
(Date:6/30/2015)... , June 30, 2015 Olympus, ... innovative solutions for medical and surgical procedures, among ... next-day replacements for surgical equipment at no additional ... to offer this type of guarantee. The service ... Service Agreement earlier this year. ...
Breaking Medicine Technology:Velos continues adding CTSA customers - 40% now use Velos products 2Millar, Inc. Announces Leadership Changes 2Millar, Inc. Announces Leadership Changes 3Olympus Introduces Industry-First Next-Day Product Replacement Guarantee for Surgical Business 2Olympus Introduces Industry-First Next-Day Product Replacement Guarantee for Surgical Business 3
... 7, 2010 Alexza Pharmaceuticals, Inc. (Nasdaq: ALXA ... Review meeting with the U.S. Food and Drug Administration (FDA) ... the Company,s New Drug Application (NDA) for AZ-004 ( Staccato ... FDA in preparation for the meeting, with the responses or ...
... Dec. 7, 2010 Apexigen, Inc. announced today ... worldwide license agreement with Centocor Research & Development, ... therapeutic antibody technologies to discover and develop monoclonal ... to several targets specified by Centocor R&D, which ...
Cached Medicine Technology:Alexza Pharmaceuticals Provides Regulatory Update for AZ-004 (Staccato® Loxapine) 2Alexza Pharmaceuticals Provides Regulatory Update for AZ-004 (Staccato® Loxapine) 3Apexigen, Inc. Announces Collaboration for Antibody Discovery 2
(Date:7/1/2015)... ... ... Recent research has revealed that most adults lack confidence in the effectiveness ... Starting the last Monday of June, Whiter Image Dental will help new ... the customer’s first popular In-Office 2 Patient Kit. , The In-Office ...
(Date:7/1/2015)... Windsor, Vermont (PRWEB) , ... July 01, 2015 ... ... systems based in Windsor, Vermont, is partnering with Mexican based water fountain manufacturer, ... children throughout Mexico. Vermont Senator Patrick Leahy, who is ranked among the top ...
(Date:6/30/2015)... California (PRWEB) , ... July 01, 2015 , ... Avid ... for 1968 Doors and Jimi Hendrix Singer Bowl concert posters. The Who and the Rascals ... August 2. According to Hawley, "The Doors played with the Who backing them ...
(Date:6/30/2015)... ... ... Carey Danis & Lowe comments on a new pretrial order ... court. The court document outlined the judge’s plan to consolidate 26 vaginal mesh lawsuits. ... & Lowe is a personal injury law firm with headquarters in St. Louis. The ...
(Date:6/30/2015)... Shippensburg, PA (PRWEB) , ... June 30, 2015 , ... ... affected by cardiovascular disease, cancer, autism, dementia, auto-immune deficiencies, or obesity. Why? , The ... , Dr. Pete Sulack, America’s Leading Stress Expert, has successfully treated over one ...
Breaking Medicine News(10 mins):Health News:Whiter Image Dental Offers New Customers Half-Off Teeth Whitening Kit 2Health News:Clean Drinking Water Now Available to Millions of Mexican Children as a Result of Partnership Between Seldon Technologies and Bebederos Ecologicos / Ottone Meloda 2Health News:Clean Drinking Water Now Available to Millions of Mexican Children as a Result of Partnership Between Seldon Technologies and Bebederos Ecologicos / Ottone Meloda 3Health News:Avid Boxing Style Rock Concert Poster Collector From Vintage Rock Posters Announces Search for 1968 Doors and Jimi Hendrix Singer Bowl Concert Posters 2Health News:Carey Danis & Lowe Comments on New Pretrial Order in Vaginal Mesh Lawsuit 2Health News:Carey Danis & Lowe Comments on New Pretrial Order in Vaginal Mesh Lawsuit 3Health News:12 Easy-To-Follow Steps to Transform Body, Mind and Spirit 2
... one of them has developed a flesh eating disease; another ... ,Necrotising fasciitis (flesh eating disease) is a rare infectious, ultimately ... spent five weeks in the hospital, and is released now. ... to the officials that the tattooist has to improve the ...
... discovered a protein interaction that may explain how the ... in and featured on the cover of the current ... Huntington’s protein interacts with another protein to cause dramatic ... ,“Cholesterol is essential for promoting the connection network among ...
... could help in fighting cancer,// a recent study issued an ... prone to a relapse of caner in the following cases: ... stem cells are from a female donor. ,This second ... the original transplant. This is more pronounced in them than ...
... Gene Therapy has published the findings of the first ... dysfunction.// The finding shows that gene therapy negates the ... beneficial for months, and hence could be the most ... author Arnold Melman, M.D., professor and chair of the ...
... has shown, in India, a majority of married women are ... Therefore, there is a definite need for protective methods that ... male-controlled methods are not even 20 percent helpful. ,A ... by over-the-counter microbicides, which are gels, creams, films, or suppositories, ...
... been told that patients undergoing chemotherapy in remote areas may ... the patient sending a text of his symptoms according to ... means of a red alert sent to medical staff, or ... of new age technology may be used along with a ...
Cached Medicine News:Health News:Link Between Huntington’s and Abnormal Cholesterol Levels in Brain Establishe 2Health News:The Other Side of Hematopoietic Stem Cell Transplant 2Health News:Gene Therapy May Be the Solution for Erectile Dysfunction 2
Designed to be removed from under surgical gown without compromising sterile fields. Two straps criss-cross in the back and attach with velcro in the front....
Wolfs unique apron and vest set distributes weight evenly between shoulders and hips. The vest comes with an attached Thyroid collar...
... Full frontal protection, our conventional ... shoulders by sturdy 2 webbed ... quick-acting snap hook fasteners. The ... custom fit the apron. Our ...
... Aprons are the result of a technologically ... x-ray aprons. Constructed with a wear resistant, ... the Lead Free aprons exhibit the same ... Each apron weighs approximately 50% less than ...
Medicine Products: