Navigation Links
Ardea Biosciences Provides Additional Results From a Phase 2b Study of Lesinurad in Combination With Allopurinol at the Annual European Congress of Rheumatology
Date:5/25/2011

f gout patients are considered to be under-excretors of uric acid, and recent studies have shown that defects in renal transporters have been genetically linked to gout.  Consequently, increasing renal excretion of uric acid by moderating URAT1 transporter activity may provide the most physiologically appropriate treatment for gout.  In addition, because increasing the excretion of serum uric acid is additive to the effects of drugs that decrease the production of uric acid, such as allopurinol and febuxostat, lesinurad in combination with such drugs has the potential to treat the significant portion of the gout population that is not adequately treated with existing therapies.

Lesinurad has been evaluated as a single agent and in combination with the approved xanthine oxidase inhibitors, allopurinol and febuxostat.  Over 500 people have received lesinurad in Phase 1 and 2 clinical trials.

About Ardea Biosciences, Inc.

Ardea Biosciences, Inc., of San Diego, California, is a biotechnology company focused on the development of small-molecule therapeutics for the treatment of serious diseases. Lesinurad, our lead product candidate for the treatment of hyperuricemia and gout, is a once-daily, oral inhibitor of the URAT1 transporter.  We have completed Phase 2b clinical studies of lesinurad and continue to advance the drug in longer term extensions in preparation for Phase 3 development.  Our next-generation URAT1 inhibitor program is currently in preclinical development. BAY 86-9766 (RDEA119), is a potent and specific inhibitor of mitogen-activated ERK kinase (MEK) for the treatment of cancer being developed under a global license agreement with Bayer HealthCare AG. BAY 86-9766 is currently in a Phase 2 study in patients with hepatocellular carcinoma in combination with sorafenib (Nexavar®; Bayer, Onyx Pharmaceuticals) and a Phase 1/Phase 2 study in patients with advanced pancreatic cancer in combinatio
'/>"/>

SOURCE Ardea Biosciences, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Ardea Biosciences, Inc. Announces Completion of Phase 1 Clinical Trials of Novel Investigational HIV Drug RDEA806
2. Ardea Biosciences, Inc. Presents Results of Phase 1 Studies of RDEA806, a Novel NNRTI for HIV, at 47th ICAAC
3. Ardea Biosciences Lead MEK Inhibitor, RDEA119, to Enter Human Clinical Trials in Advanced Cancer Patients
4. Ardea Biosciences, Inc. Announces New Clinical Development Program Directed Toward the Treatment of Gout
5. Ardea Biosciences Presents Preclinical Data Demonstrating Favorable Resistance Profiles for Non-Nucleoside Reverse Transcriptase Inhibitors for the Treatment of Human Immunodeficiency Virus
6. Ardea Biosciences Reports Positive Phase 2a Results for Lead HIV Candidate, RDEA806, Demonstrating up to 2.0 Log Reduction in Plasma Viral Load
7. Ardea Biosciences Presents Data Demonstrating Favorable Pharmacokinetics and Efficacy for Mitogen-Activated ERK Kinase (MEK) Inhibitors
8. Ardea Biosciences Appoints John W. Beck Chief Financial Officer, Announces Clinical Development Progress and Reports First Quarter 2008 Financial Results
9. Ardea Biosciences Identifies Lead Development Candidate for Gout, RDEA594
10. Ardea Biosciences Presents Preclinical Data on RDEA119 Demonstrating Favorable Anti-Inflammatory Profile for Potential Use in Ulcerative Colitis
11. Ardea Announces Progress with HIV Non-Nucleoside Reverse Transcriptase Inhibitor Program
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... Research and Markets has announced the addition ... Pipeline Insight 2014" report to their offering. ... eradicate the prevalence of cancer have achieved limited success ... specificity, safety and large number of side effects, which ... It has been discovered that peptides can be used ...
(Date:8/29/2014)... 2014 According to a ... Extraction type (SFE, Cold Pressed, Organic Solvent, & Others), ... Food Supplements, Fragrance, & Others) - Global Trends & ... segments the Amaranth Seed Oil Market with an ... terms of value. The Amaranth Seed Oil Market ...
(Date:8/29/2014)... Research and Markets has announced ... Forecast of Pharmaceutical Equipment Market in China, 2014-2018" ... Development Trend Forecast of Pharmaceutical Equipment Market in ... China,s pharmaceutical equipment industry in the aspects ... and business performance of domestic major enterprises, as well ...
Breaking Medicine Technology:Global Peptide Cancer Therapeutics Market & Pipeline Insight 2014 2Amaranth Seed Oil Market worth $700.6 Million by 2019 2Amaranth Seed Oil Market worth $700.6 Million by 2019 3Amaranth Seed Oil Market worth $700.6 Million by 2019 4Research and Development Trend Forecast of Pharmaceutical Equipment Market in China, 2014-2018 2
... INDIANAPOLIS, Oct. 11, 2011 Eli Lilly and ... due to the December 31 retirements of longtime senior leaders, ... whose Lilly career spans 36 years, has led Lilly Bio-Medicines ... Lilly spans 33 years, has led global manufacturing operations since ...
... 2011 MedPro Imaging, a premium provider of new and ... transducer repair capabilities to include GE E8/E9 transducers.  MedPro is ... probes for the GE E8/E9 ultrasound systems and has been ... care systems for the past six months. In ...
Cached Medicine Technology:Lilly Announces Changes in Senior Management 2Lilly Announces Changes in Senior Management 3Lilly Announces Changes in Senior Management 4MedPro Imaging to Repair GE E8/E9 Ultrasound Transducers 2
(Date:8/30/2014)... August 30, 2014 In today’s world, ... increasingly difficult to get. Snoring and sleep apnea (a ... breathing stops) robs people and their bed partners of ... Up to 45% of the population snores and 20 ... apnea. Of these, only 10% have been diagnosed and ...
(Date:8/30/2014)... The new review published by Daily Gossip ... Karen Brimeyer, who wanted to make her guide accessible to ... is now easy to find in the form of an ... the author of the new method shares all her tips ... writes in its review that the leaky gut syndrome can ...
(Date:8/30/2014)... 2014 LiveStreamingFitness.com, a company dedicated to providing ... lifestyle resources, is proud to announce it has been recognized ... home fitness solutions by ABC’s Good Morning America. ... ABC’s Good Morning America, “Live Streaming Fitness is the hottest ... day by streamlining your workout…to boot camp at Life Streaming ...
(Date:8/30/2014)... August 30, 2014 When a prominent bank ... as happened on Wednesday, August 27th, when news began surfacing ... JPMorgan Chase & Co and at least one other ... actually investigating attacks on seven prominent banks , everyone ... be affected, and the buzz quickly goes viral. Bloomberg ...
(Date:8/30/2014)... 30, 2014 Final Cut Pro ... the TransGhost plugin from Pixel Film Studios. , “The ... the ability to tell their scary story in a ... Studios. “Users will make their audience scream with this ... With TransGhost users can awaken evil spirits with over ...
Breaking Medicine News(10 mins):Health News:Snoring: Bad for Relationships, Bad for Health 2Health News:Snoring: Bad for Relationships, Bad for Health 3Health News:Leaky Gut Cure Review Reveals Unique Method to Stop Chronic Symptoms 2Health News:LiveStreamingFitness.com is New Trend In Fitness 2Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 2Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 3Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 4Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 5Health News:Pixel Film Studios Released TransGhost Plugin for Final Cut Pro X Today 2Health News:Pixel Film Studios Released TransGhost Plugin for Final Cut Pro X Today 3
... SHANGHAI, China, Oct. 5 ... "the Company"), a leading Chinese firm,specializing in the ... today announced the closing of its,previously announced underwritten ... common stock at $15.00 per share in its ...
... stressed at some point in their life, and there are all ... financial concerns when a 401 (k) loses value, increased workload after ... money woes -- just to name a few. , See video ... easy to get stressed out over stress, but there are two ...
... care units die within 24 hours, but the environment is ... nevertheless happy with the care given, shows a thesis from ... An intensive care unit (ICU) is designed primarily to save ... on an ICU, this often follows a sudden illness or ...
... , ... Blackburn, PhD, 60, of the University of California, San Francisco, today was named to receive ... Greider of Johns Hopkins University School of Medicine and Jack W. Szostak of Harvard Medical ... San Francisco, CA ...
... Calif., Oct. 5 Trapeze Networks, a Belden Brand ... "Trapeze Medical," with the goal of extending the company,s ... Trapeze Medical is focused on three strategies: It ... to the hospitals, clinics and residential care facilities, help ...
... Children in hardest-hit areas remain at risk, warns World Vision ... help children recover , - Aid agency calls on Indonesian ... , PADANG, Indonesia, Oct. 5 As schoolchildren in Indonesia,s ... aid group World Vision says these thousands of children affected ...
Cached Medicine News:Health News:China-Biotics, Inc. Announces Closing of Public Offering of Common Stock 2Health News:China-Biotics, Inc. Announces Closing of Public Offering of Common Stock 3Health News:VIDEO from Medialink and CIGNA: Don't Stress Out Over Stress, Some of it is Good for You 2Health News:Intensive care units poorly equipped to care for the dying 2Health News:UCSF Scientist Receives Nobel Prize in Physiology or Medicine 2Health News:UCSF Scientist Receives Nobel Prize in Physiology or Medicine 3Health News:UCSF Scientist Receives Nobel Prize in Physiology or Medicine 4Health News:Trapeze Networks Announces Trapeze Medical, Bringing Medical-Grade Mobility to Healthcare Market 2Health News:As Schools Reopen in Indonesia, World Vision Says Children's Basic Needs Still Not Being Met 2
... of P.falciparum specific histidine ... specific pLDH and pan malaria ... of P. falciparum and ... other malarial species and for the ...
... a two site sandwich immunoassay ... detection of P. falciparum specific ... and P. vivax specific pLDH. ... used for specific detection and ...
Malaria Pf. Assay Range...
ADVANTAGE MALARIA STIX is a visual, rapid and sensitive immunoassay for the qualitative differential detection of P.falciparum (P.f) and P.vivax (P.v) malaria in Human Blood only....
Medicine Products: