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Ardea Biosciences Provides Additional Results From a Phase 2b Study of Lesinurad in Combination With Allopurinol at the Annual European Congress of Rheumatology
Date:5/25/2011

der Scientific Publications under the following titles:

  • Efficacy and Safety of Lesinurad (RDEA594), A Novel Uricosuric Agent, Given in Combination with Allopurinol in Allopurinol-Refractory Gout Patients: Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study
  • Lesinurad (RDEA594), A Novel Investigational Uricosuric Agent for Hyperuricemia and Gout, Blocks Transport of Uric Acid Induced by Hydrochlorothiazide  
  • Lesinurad (RDEA594), A Novel Uricosuric Agent, In Combination with Febuxostat Shows Significant Additive Urate Lowering Effects in Gout Patients with 100% Response Achieved For All Combination Dose Regimens

About Hyperuricemia and Gout

Gout is a painful, debilitating and progressive disease caused by abnormally elevated levels of uric acid in the blood stream.  This leads to the deposition of painful, needle-like uric acid crystals in and around the connective tissue of the joints and in the kidneys, resulting in inflammation, the formation of disfiguring nodules, intermittent attacks of severe pain and kidney damage.  In addition, evidence suggests that the chronic elevation of uric acid associated with gout, known as hyperuricemia, may also have systemic consequences, including an increased risk for kidney dysfunction and cardiovascular disease.

In 2008, approximately 8.3 million patients in the U.S., 6.4 million patients in the European Union and 2.9 million patients in Japan were diagnosed with gout.  Gout is the most common form of inflammatory arthritis in men over the age of 40 and represents a significant unmet medical need with limited treatment options.

About Lesinurad

Our most advanced product candidate for the treatment of hyperuricemia and gout, lesinurad is an oral, once-daily inhibitor of URAT1, a transporter in the kidney that regulates uric acid excretion from the body.  Approximately 90 percent o
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SOURCE Ardea Biosciences, Inc.
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3. Ardea Biosciences Lead MEK Inhibitor, RDEA119, to Enter Human Clinical Trials in Advanced Cancer Patients
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5. Ardea Biosciences Presents Preclinical Data Demonstrating Favorable Resistance Profiles for Non-Nucleoside Reverse Transcriptase Inhibitors for the Treatment of Human Immunodeficiency Virus
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11. Ardea Announces Progress with HIV Non-Nucleoside Reverse Transcriptase Inhibitor Program
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